56 research outputs found
Modelling the Pan-Spectral Energy Distribution of Starburst Galaxies: I. The role of ISM pressure & the Molecular Cloud Dissipation Timescale
In this paper, we combine the stellar spectral synthesis code STARBURST 99,
the nebular modelling code MAPPINGS IIIq, a 1-D dynamical evolution model of
\HII regions around massive clusters of young stars and a simplified model of
synchrotron emissivity to produce purely theoretical self-consistent synthetic
spectral energy distributions (SEDs) for (solar metallicity) starbursts lasting
some years. These SEDs extend from the Lyman Limit to beyond 21 cm. We
find that two ISM parameters control the form of the SED; the pressure in the
diffuse phase of the ISM (or, equivalently, its density), and the molecular
cloud dissipation timescale. We present detailed SED fits to Arp 220 and NGC
6240, and we give the predicted colors for starburst galaxies derived from our
models for the IRAS and the Spitzer Space Observatory MIPS and IRAC
instruments. Our models reproduce the spread in observed colors of starburst
galaxies. Finally, we present absolute calibrations to convert observed fluxes
into star formation rates in the UV (GALEX), at optical wavelengths
(H), and in the IR (IRAS or the Spitzer Space Observatory). (Abstract
Truncated)Comment: 56 pages, 16 figures, accepted by The Apstrophysical Journal For
version with full, colour figures go to
http://www.mso.anu.edu.au/~bgroves/starburst
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Sociology and Politics: Parsons - *Talcott Parsons: Politics and Social Structure. (New York: Macmillan-The Free Press, 1969. Pp. 557. $13.50.)
NASA and the Phenomenology of Discovery: Vigilance, Work Conditions, and a Renewed Space Policy
NASA and the Phenomenology of Discovery: Vigilance, Work Conditions, and a Renewed Space Policy
Uncovering Validity Criteria for Stories Managers Hear and Tell
}Policymakers and managers rely to a large extent on stories told to them for information that shapes problem formulation and decision. But what can give them confidence in such stories? In this article, one of several articles by the author in which the value of stories is examined, the social origins of validity standards for storytelling. Based on sociological theory regarding the construction of social reality, the author argues that four questions typically are asked when the validity of a story is to be tested.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
- …