The Role of Fecal Calprotectin in Investigating Inflammatory Bowel Diseases

INTRODUCTION: Invasive and non-invasive tests can be used to evaluate the activity of inflammatory bowel diseases. OBJECTIVE: The aim of the present study was to investigate the role of fecal calprotectin in evaluating inflammatory bowel disease activity and the correlation of fecal calprotectin with the erythrocyte sedimentation rate and C reactive protein values in inflammatory bowel disease. METHOD: Sixty-five patients affected with inflammatory bowel disease were enrolled. Twenty outpatients diagnosed with inflammatory bowel disease comprised the control group. RESULTS: In the present study, all patients in the control group had an fecal calprotectin value lower than the cut-off point (50 mg/kg). CONCLUSION: In conclusion, fecal calprotectin was found to be strongly associated with colorectal inflammation indicating organic disease. Fecal calprotectin is a simple and non-invasive method for assessing excretion of macrophages into the gut lumen. Fecal calprotectin values can be used to evaluate the response to treatment, to screen asymptomatic patients, and to predict inflammatory bowel disease relapses

Preparation of a new nanoconductive ROMP copolymer and its application as solid polymer electrolyte

WOS: 000325671000010New thermoplastic host copolymer based on oxanorbornene dicarboximides for solid polymer electrolytes was synthesized and characterized by spectral methods. The corresponding new nanoconductive ROMP copolymers were prepared through doping of lithium salt, LiBF4. The effect of lithium concentration on the conduction behavior of new SPEs was studied. The conductivity measurements were carried out on thin films of the nanostructured solid polymer electrolytes. The maximum conductivity (1.27 x 10(-5) S cm(-1)) was obtained for a copolymer complex with 10 wt.% LiBF4. (c) 2013 Elsevier B.V. All rights reserved.Kirikkale University Scientific Research Projects Coordination Unit (Turkey)Kirikkale University [2012/12]We thank Kirikkale University Scientific Research Projects Coordination Unit (Turkey) for the financial assistance through the project (project No. 2012/12)

Solution of Space-Time-Fractional Problem by Shehu Variational Iteration Method

In this study, we deal with the problem of constructing semianalytical solution of mathematical problems including space-time-fractional linear and nonlinear differential equations. The method, called Shehu Variational Iteration Method (SVIM), applied in this study is a combination of Shehu transform (ST) and variational iteration method (VIM). First, ST is utilized to reduce the time-fractional differential equation with fractional derivative in Liouville-Caputo sense into an integer-order differential equation. Later, VIM is implemented to construct the solution of reduced differential equation. The convergence analysis of this method and illustrated examples confirm that the proposed method is one of best procedures to tackle space-time-fractional differential equations

Influence of ruthenium alkylidene complexes bearing tricyclohexylphosphine or 3-bromopyridine ligand on the properties of fluorine containing polymers

WOS: 000321921800018The catalytic performance of ruthenium alkylidene complexes bearing tricyclohexylphosphine or 3-bromopyridine ligand in the ring opening metathesis polymerization (ROMP) of fluorine containing monomers, exo-N-4-fluorophenyl-7-oxanorbornene-5,6-dicarboximide (FPhONDI) and exo-N-4-fluorophenyl-norbornene-5,6-dicarboximide (FPhNDI) was investigated. Pure monomers were subjected to ROMP with RuCl2(PCy3)(2)(CHPh) (I), RuCl2(PCy3)(H(2)IMes)(CHPh) (II), RuCl2(3-Br-py)(2)(PCy3)(CHPh) (III) and RuCl2(3-Br-py)(2)(H(2)IMes)(CHPh) (IV). The polymers were fully characterized using NMR, DSC, SEM and GPC. Catalysts I-IV displayed significant ROMP activity, allowing for the synthesis of the corresponding polymers with polydispersity indices (PDIs) in the range of 1.4-4.0. High molecular weight polymers (Mw up to 4.95 x10(5)) were prepared in yields up to 90 %, depending on the initiator and monomer used.Kirikkale University FoundationKirikkale UniversityWe thank the Kirikkale University Foundation for the financial support of this work

Synthesis, structure, electrochemical and antimicrobial properties of N,N '-bis(ferrocenylmethyl)imidazolinium salts

WOS: 000345115900057The N, N'-bis(ferrocenylmethyl)imidazolinium chloride (3) and bromide (4) were prepared by reaction of N,N'-bis(ferrocenylmethyl)ethylenediamine (2) with NH4X (X = Cl, Br). The N,N'-bis(ferrocenylmethyl)imidazolinium tetrafluoroborate (6) was obtained in two steps from compound (2). The first step involves the synthesis of N,N'-bis(ferrocenylmethyl)imidazolidine (5) by condensation of (2) with aqueous formaldehyde. Compound (5) was successfully converted to the N,N'-bis(ferrocenylmethyl)imidazolinium tetrafluoroborate (6) by treatment with tritylium tetrafluoroborate. The new compounds were characterized by H-1 and C-13 NMR, IR and elemental analysis techniques which support the proposed structures. The X-ray crystal structure of the N,N'-bis(ferrocenylmethyl)imidazolidine (5) shows two ferrocenyl moieties bridged by an imidazolidine ring. The electrochemical properties were determined by cyclic voltammetry for all compounds. The compounds were screened for their in vitro antimicrobial activities against the Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. (3), (4), (6) show significant antimicrobial activity and theirs MIC values ranged from 169 to 520 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.Celal Bayar UniversityCelal Bayar University [BAP 2011-033, BAP 2012-078]This work was financially supported by Celal Bayar University (BAP 2011-033, BAP 2012-078). We thank Prof. Stephen T. Astley of Ege University for assistance in checking the English language of the manuscript and Asst. Prof. Dr. Suleyman Kocak for helpful discussion on CV studies

The relevance of multiplex PCR and heterodublex analysis on differentiating the reactive versus neoplastic T cells in the spectrum of gluten sensitive enteropathy - Enteropathy associated T cell lymphoma.

WOS: 00024945460018

PON1 55/192 polymorphism, oxidative stress, type, prognosis and severity of stroke

We investigated the association of PON1 55/192 polymorphisms with type, severity and prognosis of stroke and oxidative markers. Paraoxonase1 (PON1), Glutathione Reductase (GSH-Rd) and Malondialdehyde (MDA) levels were measured at day 1 and at day 5 following the onset of stroke. Genotypes were determined by polymerase chain reaction and restriction digestion. The frequencies of QQ and MM genotypes of PON1 192 and PON1 55, respectively, were significantly higher in controls than in patients. However, the allele frequencies of PON1 192 R and PON1 55 L were significantly more frequent in patients compared to controls. The frequency of combined genotype of RR/LL was significantly higher in cardioembolic group than in atherothrombotic group. PON1 activities were significantly diminished in stroke patients compared to controls. In contrast, serum MDA levels were significantly greater in patients than the values in controls. GSH-Rd activity was higher in patients with small lesion and good prognosis than those with large and poor prognosis. Low density lipoprotein (LDL) levels in patients with large lesions were higher than those with small lesions. PON1 55/192 polymorphisms influence activity of the enzyme. PON1 55/192 genotypes have been associated with MDA levels. In conclusion, PON1 genetic variations are associated with risk factors, severity, type and prognosis of stroke and oxidative stress