45 research outputs found
Fast readout algorithm for cylindrical beam position monitors providing good accuracy for particle bunches with large offsets
A simple, analytically correct algorithm is developed for calculating pencil
beam coordinates using the signals from an ideal cylindrical particle beam
position monitor (BPM) with four pickup electrodes (PUEs) of infinitesimal
widths. The algorithm is then applied to simulations of realistic BPMs with
finite width PUEs. Surprisingly small deviations are found. Simple empirically
determined correction terms reduce the deviations even further. The algorithm
is then used to study the impact of beam-size upon the precision of BPMs in the
non-linear region. As an example of the data acquisition speed advantage, a
FPGA-based BPM readout implementation of the new algorithm has been developed
and characterized. Finally,the algorithm is tested with BPM data from the
Cornell Preinjector.Comment: 21 pages, 17 figure
Targeted ToF-SIMS Analysis of Macrophage Content from a Human Cranial Triphasic Calcium Phosphate Implant
Macrophages play a key role in determining the fate of implanted biomaterials, especially for biomaterials such as calcium phosphates (CaPs) where these cells play a vital role in material resorption and osteogenesis, as shown in different models, including clinical samples. Although substantial consideration is given to the design and validation of different CaPs, relatively little is known about their material-cell interaction. Specifically, the intracellular content of different CaP phases remains to be assessed, even though CaP-filled macrophages have been observed in several studies. In this study, 2D/3D ToF-SIMS imaging and multivariate analysis were directly applied on the histology samples of an explant to reveal the content of macrophages. The cellular content of the macrophages was analyzed to distinguish three CaP phases, monetite, beta-tricalcium phosphate, and pyrophosphate, which are all part of the monetite-based CaP implant composition under study. ToF-SIMS combined with histology revealed that the content of the identified macrophages was most similar to that of the pyrophosphate phase. This study is the first to uncover distinct CaP phases in macrophages from a human multiphasic CaP explant by targeted direct cell content analysis. The uncovering of pyrophosphate as the main phase found inside the macrophages is of great importance to understand the impact of the selected material in the process of biomaterial-instructed osteogenesis
A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis.
New regenerative materials and approaches need to be assessed through reliable and comparable methods for rapid translation to the clinic. There is a considerable need for proven in vitro assays that are able to reduce the burden on animal testing, by allowing assessment of biomaterial utility predictive of the results currently obtained through in vivo studies. The purpose of this multicentre review was to investigate the correlation between existing in vitro results with in vivo outcomes observed for a range of biomaterials. Members from the European consortium BioDesign, comprising 8 universities in a European multicentre study, provided data from 36 in vivo studies and 47 in vitro assays testing 93 different biomaterials. The outcomes of the in vitro and in vivo experiments were scored according to commonly recognised measures of success relevant to each experiment. The correlation of in vitro with in vivo scores for each assay alone and in combination was assessed. A surprisingly poor correlation between in vitro and in vivo assessments of biomaterials was revealed indicating a clear need for further development of relevant in vitro assays. There was no significant overall correlation between in vitro and in vivo outcome. The mean in vitro scores revealed a trend of covariance to in vivo score with 58 %. The inadequacies of the current in vitro assessments highlighted here further stress the need for the development of novel approaches to in vitro biomaterial testing and validated pre-clinical pipelines
Recommended from our members
The dipole corrector magnets for the RHIC fast global orbit feedback system
The recently completed RHIC fast global orbit feedback system uses 24 small 'window-frame' horizontal dipole correctors. Space limitations dictated a very compact design. The magnetic design and modelling of these laminated yoke magnets is described as well as the mechanical implementation, coil winding, vacuum impregnation, etc. Test procedures to determine the field quality and frequency response are described. The results of these measurements are presented and discussed. A small fringe field from each magnet, overlapping the opposite RHIC ring, is compensated by a correction winding placed on the opposite ring's magnet and connected in series with the main winding of the first one. Results from measurements of this compensation scheme are shown and discussed
Recommended from our members
Experience with low-energy gold-gold operations in RHIC during FY 2010
N/
Recommended from our members
Fast BPM data distribution for global orbit feedback using commercial gigabit ethernet technology
In order to correct beam perturbations in RHIC around 10Hz, a new fast data distribution network was required to deliver BPM position data at rates several orders of magnitude above the capability of the existing system. The urgency of the project limited the amount of custom hardware that could be developed, which dictated the use of as much commercially available equipment as possible. The selected architecture uses a custom hardware interface to the existing RHIC BPM electronics together with commercially available Gigabit Ethernet switches to distribute position data to devices located around the collider ring. Using the minimum Ethernet packet size and a field programmable gate array (FPGA) based state machine logic instead of a software based driver, real-time and deterministic data delivery is possible using Ethernet. The method of adapting this protocol for low latency data delivery, bench testing of Ethernet hardware, and the logic to construct Ethernet packets using FPGA hardware will be discussed. A robust communications system using almost all commercial off-the-shelf equipment was developed in under a year which enabled retrofitting of the existing RHIC BPM system to provide 10 KHz data delivery for a global orbit feedback scheme using 72 BPMs. Total latencies from data acquisition at the BPMs to delivery at the controller modules, including very long transmission distances, were kept under 100 {micro}s, which provide very little phase error in correcting the 10 Hz oscillations. Leveraging off of the speed of Gigabit Ethernet and wide availability of Ethernet products enabled this solution to be fully implemented in a much shorter time and at lower cost than if a similar network was developed using a proprietary method
Recommended from our members
Precision tune, phase and beta function measurement by frequency analysis in RHIC
N/
Recommended from our members
Weighted SVD algorithm for close-orbit correction and 10 Hz feedback in RHIC
Measurements of the beam position along an accelerator are typically treated equally using standard SVD-based orbit correction algorithms so distributing the residual errors, modulo the local beta function, equally at the measurement locations. However, sometimes a more stable orbit at select locations is desirable. In this paper, we introduce an algorithm for weighting the beam position measurements to achieve a more stable local orbit. The results of its application to close-orbit correction and 10 Hz orbit feedback are presented