662 research outputs found
Influence of flow confinement on the drag force on a static cylinder
The influence of confinement on the drag force on a static cylinder in a
viscous flow inside a rectangular slit of aperture has been investigated
from experimental measurements and numerical simulations. At low enough
Reynolds numbers, varies linearly with the mean velocity and the viscosity,
allowing for the precise determination of drag coefficients and
corresponding respectively to a mean flow parallel and
perpendicular to the cylinder length . In the parallel configuration, the
variation of with the normalized diameter of the
cylinder is close to that for a 2D flow invariant in the direction of the
cylinder axis and does not diverge when . The variation of
with the distance from the midplane of the model reflects the
parabolic Poiseuille profile between the plates for while it
remains almost constant for . In the perpendicular configuration,
the value of is close to that corresponding to a 2D system
only if and/or if the clearance between the ends of the cylinder
and the side walls is very small: in that latter case,
diverges as due to the blockage of the flow. In other cases, the
side flow between the ends of the cylinder and the side walls plays an
important part to reduce : a full 3D description of the flow is
needed to account for these effects
Traffic jams and intermittent flows in microfluidic networks
We investigate both experimentally and theoretically the traffic of particles
flowing in microfluidic obstacle networks. We show that the traffic dynamics is
a non-linear process: the particle current does not scale with the particle
density even in the dilute limit where no particle collision occurs. We
demonstrate that this non-linear behavior stems from long range hydrodynamic
interactions. Importantly, we also establish that there exists a maximal
current above which no stationary particle flow can be sustained. For higher
current values, intermittent traffic jams form thereby inducing the ejection of
the particles from the initial path and the subsequent invasion of the network.
Eventually, we put our findings in the broader context of the transport
proccesses of driven particles in low dimension
Failure mechanisms and surface roughness statistics of fractured Fontainebleau sandstone
In an effort to investigate the link between failure mechanisms and the
geometry of fractures of compacted grains materials, a detailed statistical
analysis of the surfaces of fractured Fontainebleau sandstones has been
achieved. The roughness of samples of different widths W is shown to be self
affine with an exponent zeta=0.46 +- 0.05 over a range of length scales ranging
from the grain size d up to an upper cut-off length \xi = 0.15 W. This low zeta
value is in agreement with measurements on other sandstones and on sintered
materials. The probability distributions P(delta z,delta h) of the variations
of height over different distances delta z > d can be collapsed onto a single
Gaussian distribution with a suitable normalisation and do not display
multifractal features. The roughness amplitude, as characterized by the
height-height correlation over fixed distances delta z, does not depend on the
sample width, implying that no anomalous scaling of the type reported for other
materials is present. It is suggested, in agreement with recent theoretical
work, to explain these results by the occurence of brittle fracture (instead of
damage failure in materials displaying a higher value of zeta = 0.8).Comment: 7 page
Respiratory health screening for opiate misusers in a specialist community clinic: a mixed-methods pilot study, with integrated staff and service user feedback.
OBJECTIVES: Increased rates of illicit drug inhalation are thought to expose opiate misusers (OMUs) to an enhanced risk of respiratory health problems. This pilot study aimed to determine the feasibility of undertaking respiratory screening of OMUs in a community clinic. SETTING: Single-centre UK community substance misuse clinic. PARTICIPANTS: All clinic attendees receiving treatment for opiate misuse were eligible to participate. 36 participants (mean age=37) were recruited over a 5-week period. The sample included 26 males and 10 females. OUTCOME MEASURES: Spirometry without bronchodilation; health related quality of life EQ-5D-3L; Asthma Control Test; Mini Asthma Quality of Life; Clinical COPD Questionnaire and the Treatment Outcome Profile were used to assess the respiratory health of participants. Findings were discussed with staff and service users in 2 patient and public involvement events and feedback was analysed thematically. RESULTS: 34 participants reported that they had smoked heroin. 8 participants diagnosed with asthma, scored under 13 on the Asthma Control Test, suggesting poorly controlled asthma. Participants (n=28), without a diagnosis of asthma completed the Lung Function Questionnaire. Of these, 79% produced scores under 18, indicating symptoms associated with the development of chronic obstructive pulmonary disease. Spirometry showed 14% of all participants had forced expiratory volume in 1 s/forced vital capacity <0.7 (without bronchodilator), indicating potential obstructive lung disease. Feedback from service users and staff suggested a willingness and capacity to deliver respiratory health screening programmes. Insight towards the difficulties service users have in accessing services and the burden of respiratory health was also provided. CONCLUSIONS: It is feasible to undertake respiratory health screening of OMUs in a community clinic. Larger screening studies are warranted to determine the prevalence of respiratory health problems in this population. Research regarding asthma medicines adherence and access to healthcare among OMUs is also required
Spin splitting in a polarized quasi-two-dimensional exciton gas
We have observed a large spin splitting between "spin" and
heavy-hole excitons, having unbalanced populations, in undoped GaAs/AlAs
quantum wells in the absence of any external magnetic field. Time-resolved
photoluminescence spectroscopy, under excitation with circularly polarized
light, reveals that, for high excitonic density and short times after the
pulsed excitation, the emission from majority excitons lies above that of
minority ones. The amount of the splitting, which can be as large as 50% of the
binding energy, increases with excitonic density and presents a time evolution
closely connected with the degree of polarization of the luminescence. Our
results are interpreted on the light of a recently developed model, which shows
that, while intra-excitonic exchange interaction is responsible for the spin
relaxation processes, exciton-exciton interaction produces a breaking of the
spin degeneracy in two-dimensional semiconductors.Comment: Revtex, four pages; four figures, postscript file Accepted for
publication in Physical Review B (Rapid Commun.
Protein kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity*
Bones' strength is achieved and maintained through adaptation to load bearing. The role of the protein kinase PKCα in this process has not been previously reported. However, we observed a phenotype in the long bones of Prkca−/− female but not male mice, in which bone tissue progressively invades the medullary cavity in the mid-diaphysis. This bone deposition progresses with age and is prevented by disuse but unaffected by ovariectomy. Castration of male Prkca−/− but not WT mice results in the formation of small amounts of intramedullary bone. Osteoblast differentiation markers and Wnt target gene expression were up-regulated in osteoblast-like cells derived from cortical bone of female Prkca−/− mice compared with WT. Additionally, although osteoblastic cells derived from WT proliferate following exposure to estradiol or mechanical strain, those from Prkca−/− mice do not. Female Prkca−/− mice develop splenomegaly and reduced marrow GBA1 expression reminiscent of Gaucher disease, in which PKC involvement has been suggested previously. From these data, we infer that in female mice, PKCα normally serves to prevent endosteal bone formation stimulated by load bearing. This phenotype appears to be suppressed by testicular hormones in male Prkca−/− mice. Within osteoblastic cells, PKCα enhances proliferation and suppresses differentiation, and this regulation involves the Wnt pathway. These findings implicate PKCα as a target gene for therapeutic approaches in low bone mass conditions
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemia.
Hypercalcaemia is an important cause of morbidity in malignant disease. We studied the efficacy and safety of intravenous ibandronate (a new, potent bisphosphonate) in a multicentre study of 147 patients with severe cancer-associated hypercalcaemia which had been resistant to treatment with rehydration alone. Of 131 randomized patients who were eligible for evaluation, 45 were allocated to receive 2 mg ibandronate, 44 patients to receive 4 mg and 42 patients to receive 6 mg. Serum calcium values fell progressively in each group from day 2, reaching a nadir at day 5, and in some patients normocalcaemia was maintained for up to 36 days after treatment. The 2-mg dose was significantly less effective than the 4-mg or 6-mg dose in correcting hypercalcaemia, as the number of patients who achieved serum calcium values below 2.7 mM after treatment was 50% in the 2-mg group compared with 75.6% in the 4-mg group and 77.4% in the 6-mg group (P < 0.05; 2 mg vs others). In a logistic regression analysis, three factors were found to predict response; ibandronate dose (higher doses were more effective), severity of presenting hypercalcaemia (severe hypercalcaemia was associated with less complete response) and tumour type (patients with breast carcinoma and haematological tumours responded better than those with other tumours). Ibandronate was generally well tolerated and no serious drug-related adverse events were observed. We conclude that ibandronate is a safe, well tolerated and effective treatment for cancer-associated hypercalcaemia, which should prove a useful addition to the current range of therapies available to treat this condition
A novel protamine variant reversal of heparin anticoagulation in human blood in vitro
AbstractPurpose: Protamine reversal of heparin anticoagulation during cardiovascular surgery may cause severe hypotension and pulmonary hypertension. A novel protamine variant, [+18RGD], has been developed that effectively reverses heparin anticoagulation without toxicity in canine experiments. Heretofore, human studies have not been undertaken. This investigation hypothesized that [+18RGD] would effectively reverse heparin anticoagulation of human blood in vitro. Methods: Fifty patients who underwent anticoagulation therapy during vascular surgery had blood sampled at baseline and 30 minutes after receiving heparin (150 IU/kg). Activated clotting times were used to define specific quantities of [+18RGD] or protamine necessary to completely reverse heparin anticoagulation in the blood sample of each patient. These defined amounts of [+18RGD] or protamine were then administered to the heparinized blood samples, and percent reversals of activated partial thromboplastin time, thrombin clotting time, and antifactor Xa/IIa levels were determined. In addition, platelet aggregation assays, as well as platelet and white blood cell counts were performed. Results: [+18RGD] and protamine were equivalent in reversing heparin as assessed by thrombin clotting time, antifactor Xa, antifactor IIa levels, and white blood cell changes. [+18RGD], when compared with protamine, was superior in this regard, as assessed by activated partial thromboplastin time (94.5 ± 1.0 vs 86.5 ± 1.3%δ, respectively; p < 0.001) and platelet declines (–3.9 ± 2.9 vs –12.8 ± 3.4 per mm3, respectively; p = 0.048). Platelet aggregation was also decreased for [+18RGD] compared with protamine (23.6 ± 1.5 vs 28.5 ± 1.9%, respectively; p = 0.048). Conclusions: [+18RGD] was as effective as protamine for in vitro reversal of heparin anticoagulation by most coagulation assays, was statistically more effective at reversal than protamine by aPTT assay, and was associated with lesser platelet reductions than protamine. [+18RGD], if less toxic than protamine in human beings, would allow for effective clinical reversal of heparin anticoagulation. (J Vasc Surg 1997;26:1043-8.
Quantum saturation and condensation of excitons in CuO: a theoretical study
Recent experiments on high density excitons in CuO provide evidence for
degenerate quantum statistics and Bose-Einstein condensation of this nearly
ideal gas. We model the time dependence of this bosonic system including
exciton decay mechanisms, energy exchange with phonons, and interconversion
between ortho (triplet-state) and para (singlet-state) excitons, using
parameters for the excitonic decay, the coupling to acoustic and low-lying
optical phonons, Auger recombination, and ortho-para interconversion derived
from experiment. The single adjustable parameter in our model is the
optical-phonon cooling rate for Auger and laser-produced hot excitons. We show
that the orthoexcitons move along the phase boundary without crossing it (i.e.,
exhibit a ``quantum saturation''), as a consequence of the balance of entropy
changes due to cooling of excitons by phonons and heating by the non-radiative
Auger two-exciton recombination process. The Auger annihilation rate for
para-para collisions is much smaller than that for ortho-para and ortho-ortho
collisions, explaining why, under the given experimental conditions, the
paraexcitons condense while the orthoexcitons fail to do so.Comment: Revised to improve clarity and physical content 18 pages, revtex,
figures available from G. Kavoulakis, Physics Department, University of
Illinois, Urban
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