Probing Dark QCD Sector through the Higgs Portal with Machine Learning at the LHC

The QCD-like dark sector with GeV-scale dark hadrons has the potential to generate new signatures at the Large Hadron Collider (LHC). In this paper, we consider a singlet scalar mediator in the tens of GeV-scale that connects the dark sector and the Standard Model (SM) sector via the Higgs portal. We focus on the Higgs-strahlung process, $q\overline{q}'\rightarrow W^{\ast}\rightarrow WH$, to produce a highly boosted Higgs boson. Our scenario predicts two different processes that can generate dark mesons: (1) the cascade decay from the Higgs boson to two light scalar mediators and then to four dark mesons; (2) the Higgs boson decaying to two dark quarks, which then undergo a QCD-like shower and hadronization to produce dark mesons. We apply machine learning techniques, such as Convolutional Neural Network (CNN) and Energy Flow Network (EFN), to the fat jet structure to distinguish these signal processes from large SM backgrounds. We find that the branching ratio of the Higgs boson to two light scalar mediators can be constrained to be less than $10\%$ at 14 TeV LHC with $\mathcal{L} = 3000 fb^{-1}$.Comment: 54 pages, 20 figures, discussions and references added.Matches JHEP accepted versio

Nested sampling statistical errors

Nested sampling (NS) is a popular algorithm for Bayesian computation. We investigate statistical errors in NS both analytically and numerically. We show two analytic results. First, we show that the leading terms in Skilling's expression using information theory match the leading terms in Keeton's expression from an analysis of moments. This approximate agreement was previously only known numerically and was somewhat mysterious. Second, we show that the uncertainty in single NS runs approximately equals the standard deviation in repeated NS runs. Whilst intuitive, this was previously taken for granted. We close by investigating our results and their assumptions in several numerical examples, including cases in which NS uncertainties increase without bound.Comment: 12 pages + appendices, 3 figure

REMEDIAL APPLICATIONS OF SILENCING RIBONUCLEIC ACIDS AND MODALITIES FOR ITS DELIVERY TO THE KIDNEYS - A REVIEW

Background: The Kidney has been the target organ for the delivery of silencing ribonucleic acids (silencing RNA) administered systemically in comparison to other body tissues. Materials and method: In this review, we discussed different approaches made to delivering proteins to the kidneys in different conditions like normal and pathological defects. Data from clinical experiments have been used to discuss and support the administration of silencing RNA for the treatment of kidney diseases. Results: Results were achieved using the available genome wide RNA libraries. Conclusion: The research results are helpful in application to 3D and conventional models to find the involvement of signal pathways in kidney diseases

A new, potential and safe neoadjuvant therapy strategy in epidermal growth factor receptor mutation-positive resectable non-small-cell lung cancer-targeted therapy: a retrospective study

BackgroundStudies of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in resectable non-small-cell lung cancer (NSCLC) have been conducted. The purpose of our study was to evaluate the benefits of osimertinib as neoadjuvant therapy for resectable EGFR-mutated NSCLC.MethodThis retrospective study evaluated patients with EGFR mutations in exon 19 or 21 who received targeted therapy with osimertinib (80 mg per day) before surgery between January 2019 and October 2023 in Henan Cancer Hospital.ResultsTwenty patients were evaluated, all of whom underwent surgery. The rate of R0 resection was 100% (20/20). The objective response rate was 80% (16/20), and the disease control rate was 95% (19/20). Postoperative pathological analysis showed a 25% (5/20) major pathological response rate and 15% (3/20) pathological complete response rate. In total, 25% (5/20) developed adverse events (AEs), and the rate of grades 3–4 AEs was 10% (2/20). One patient experienced a grade 3 skin rash, and 1 patient experienced grade 3 diarrhea.ConclusionOsimertinib as neoadjuvant therapy for resectable EGFR-mutated NSCLC is safe and well tolerated. Osimertinib has the potential to improve the radical resection rate and prognosis

Self-assembling and pH-responsive protein nanoparticle as potential platform for targeted tumor therapy

Frequent injections at high concentrations are often required for many therapeutic proteins due to their short in vivo half-life, which usually leads to unsatisfactory therapeutic outcomes, adverse side effects, high cost, and poor patient compliance. Herein we report a supramolecular strategy, self-assembling and pH regulated fusion protein to extend the in vivo half-life and tumor targeting ability of a therapeutically important protein trichosanthin (TCS). TCS was genetically fused to the N-terminus of a self-assembling protein, Sup35p prion domain (Sup35), to form a fusion protein of TCS-Sup35 that self-assembled into uniform spherical TCS-Sup35 nanoparticles (TCS-Sup35 NP) rather than classic nanofibrils. Importantly, due to the pH response ability, TCS-Sup35 NP well retained the bioactivity of TCS and possessed a 21.5-fold longer in vivo half-life than native TCS in a mouse model. As a result, in a tumor-bearing mouse model, TCS-Sup35 NP exhibited significantly improved tumor accumulation and antitumor activity without detectable systemic toxicity as compared with native TCS. These findings suggest that self-assembling and pH responding protein fusion may provide a new, simple, general, and effective solution to remarkably improve the pharmacological performance of therapeutic proteins with short circulation half-lives

A PD-1 Inhibitor Induces Complete Response of Advanced Bladder Urothelial Carcinoma: A Case Report

The prognosis of patients with advanced urothelial carcinoma is dismal. Platinum-based chemotherapy is still the main first-line treatment for advanced urothelial carcinoma, while immunotherapy can be used as a first-line treatment option for people who cannot tolerate platinum. Immunotherapy is preferred in the second-line treatment of bladder urothelial carcinoma. PD-1 inhibitors (Pembrolizumab, nivolumab and atezolizumab) and PD-L1 inhibitors (Ddurvalumab and avelumab) have not been approved for the treatment of advanced urothelial cancer in China. We describe a patient with advanced urothelial carcinoma experienced disease progression after gemcitabine chemotherapy. Following a treatment of domestic PD-1 inhibitor (sintilimab), the patient achieved a durable complete response with mild toxicity. This case indicates that PD-1 inhibitor sintilimab might be a second-line treatment choice for advanced urothelial carcinoma

Priming Watermelon Resistance by Activating Physiological Response and Defense Gene Expression to Alleviate Fusarium Wilt in Wheat-Watermelon Intercropping

Wheat intercropping in watermelon could provide relief from the occurrence of Fusarium wilting of watermelon, a severe soil-borne disease caused by the fungus Fusarium oxysporum f. sp. niveum (FON). The current study aims to investigate the effect of root exudates from three wheat cultivars and one watermelon cultivar on the growth of FON and the responses of Fusarium wilt in watermelon to intercropping with wheat. The results revealed the contrasting effects of root exudates on the mycelial growth of FON; the wheat root exudates inhibited the mycelial growth of FON, and watermelon root exudates promoted the mycelial growth of FON. Watermelon plants suffered less Fusarium wilt in the intercropping system than in the monocropping system. Wheat intercropping reduced the incidence of Fusarium wilt in watermelon, and this effect was associated with the role of wheat root exudates that inhibited the growth of FON. Malondialdehyde (MDA) contents decreased in the intercropping system compared with the monocropping system after FON inoculation. The catalase (CAT), superoxide dismutase (SOD), ascorbate peroxidase (APX), and polyphenol oxidase (PPO) activities, and total phenolics and flavonoid contents in the roots of watermelon in the intercropping system were significantly higher than those in the monocropping system. Real-time PCR analysis showed that ClCAT, ClSOD, ClAPX, and ClPPO defensive enzymes and ClPDF2.1 and ClPDF2.4 defensin-like gene expression were significantly induced during the early stage after FON inoculation in the intercropping system compared to the monocropping system, while peroxidases did not show a significant response to FON infection. It is suggested that intercropping with wheat alleviates Fusarium wilt of watermelon by reducing the population of FON in rhizospheric soil and activating physiological responses and defense gene expression to protect watermelon from FON infection and improve the resistance of watermelon to FON in the intercropping system