Double-impulse magnetic focusing of launched cold atoms.

We have theoretically investigated three-dimensional focusing of a launched cloud of cold atoms using a pair of magnetic lens pulses (the alternate-gradient method). Individual lenses focus radially and defocus axially or vice versa. The performance of the two possible pulse sequences are compared and found to be ideal for loading both 'pancake' and 'sausage' shaped magnetic/optical microtraps. It is shown that focusing aberrations are considerably smaller for double-impulse magnetic lenses compared to single-impulse magnetic lenses. An analysis of clouds focused by the double-impulse technique is presented

Fractional time random walk subdiffusion and anomalous transport with finite mean residence times: faster, not slower

Continuous time random walk (CTRW) subdiffusion along with the associated fractional Fokker-Planck equation (FFPE) is traditionally based on the premise of random clock with divergent mean period. This work considers an alternative CTRW and FFPE description which is featured by finite mean residence times (MRTs) in any spatial domain of finite size. Transient subdiffusive transport can occur on a very large time scale $\tau_c$ which can greatly exceed mean residence time in any trap, $\tau_c\gg$, and even not being related to it. Asymptotically, on a macroscale transport becomes normal for $t\gg\tau_c$. However, mesoscopic transport is anomalous. Differently from viscoelastic subdiffusion no long-range anti-correlations among position increments are required. Moreover, our study makes it obvious that the transient subdiffusion and transport are faster than one expects from their normal asymptotic limit on a macroscale. This observation has profound implications for anomalous mesoscopic transport processes in biological cells because of macroscopic viscosity of cytoplasm is finite

A framework for P2P application development

Although Peer-to-Peer (P2P) computing has become increasingly popular over recent years, there still exist only a very small number of application domains that have exploited it on a large scale. This can be attributed to a number of reasons including the rapid evolution of P2P technologies, coupled with their often-complex nature. This paper describes an implemented abstraction framework that seeks to aid developers in building P2P applications. A selection of example P2P applications that have been developed using this framework are also presented

EVALUATION OF THE LINCOLNSHIRE CONNEXIONS PILOT - FINAL SUMMARY REPORT

The Lincolnshire Connexions pilot provided an exciting opportunity to test out new ways of working throughout the county and to develop closer working partnership with a diverse range of youth support organisations. Lincolnshire was one of 13 areas chosen to trail a variety of initiatives to help inform the development of the new Connexions service both nationally and locally. This report was commissioned by the Lincolnshire Connexions pilot to summarise key lessons learned and discuss issues arising from the pilot activities. These range from operational to strategic, local to county-wide, and from research to action. Central to the approach was the establishment of multi-agency working designed to build on what was perceived to be best practice in Lincolnshire and Rutland and to further extend these activities. From 1st April 2001, Lincolnshire and Rutland has received additional Government funding to deliver the new Connexions Service as part of the national roll-out programme in Englan

New Goldstone multiplet for partially broken supersymmetry

The partial spontaneous breaking of rigid N=2 supersymmetry implies the existence of a massless N=1 Goldstone multiplet. In this paper we show that the spin-(1/2,1) Maxwell multiplet can play this role. We construct its full nonlinear transformation law and find the invariant Goldstone action. The spin-1 piece of the action turns out to be of Born-Infeld type, and the full superfield action is duality invariant. This leads us to conclude that the Goldstone multiplet can be associated with a D-brane solution of superstring theory for p=3. In addition, we find that N=1 chirality is preserved in the presence of the Goldstone-Maxwell multiplet. This allows us to couple it to N=1 chiral and gauge field multiplets. We find that arbitrary Kahler and superpotentials are consistent with partially broken N=2 supersymmetry.Comment: Latex, 13 pages. Version to appear in Phys. Rev.

Anomalous biased diffusion in a randomly layered medium

We present analytical results for the biased diffusion of particles moving under a constant force in a randomly layered medium. The influence of this medium on the particle dynamics is modeled by a piecewise constant random force. The long-time behavior of the particle position is studied in the frame of a continuous-time random walk on a semi-infinite one-dimensional lattice. We formulate the conditions for anomalous diffusion, derive the diffusion laws and analyze their dependence on the particle mass and the distribution of the random force.Comment: 19 pages, 1 figur

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis

Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation and aging have been described in patients affected by RA and ascribed to abnormal support by the BM microenvironment. Mesenchymal stem cells (MSC) and their progeny constitute important components of the BM niche. In this study we test the hypothesis that the onset of inflammatory arthritis is associated with altered self-renewal and differentiation of bone marrow MSC, which alters the composition of the BM microenvironment. Methods: We have used Balb/C Interleukin-1 receptor antagonist knock-out mice, which spontaneously develop RA-like disease in 100% of mice by 20 weeks of age to determine the number of mesenchymal progenitors and their differentiated progeny before, at the start and with progression of the disease. Results: We showed a decrease in the number of mesenchymal progenitors with adipogenic potential and decreased bone marrow adipogenesis before disease onset. This is associated with a decrease in osteoclastogenesis. Moreover, at the onset of disease a significant increase in all mesenchymal progenitors is observed together with a block in their differentiation to osteoblasts. This is associated with accelerated bone loss. Conclusions: Significant changes occur in the BM niche with the establishment and progression of RA-like disease. Those changes may be responsible for aspects of the disease, including the advance of osteoporosis. An understanding of the molecular mechanisms leading to those changes may lead to new strategies for therapeutic intervention

First passage time for subdiffusion: The nonextensive entropy approach versus the fractional model

We study the similarities and differences between different models concerning subdiffusion. More particularly, we calculate first passage time (FPT) distributions for subdiffusion, derived from Greens' functions of nonlinear equations obtained from Sharma-Mittal's, Tsallis's and Gauss's nonadditive entropies. Then we compare these with FPT distributions calculated from a fractional model using a subdiffusion equation with a fractional time derivative. All of Greens' functions give us exactly the same standard relation $=2 D_\alpha t^\alpha$ which characterizes subdiffusion ($0<\alpha<1$), but generally FPT's are not equivalent to one another. We will show here that the FPT distribution for the fractional model is asymptotically equal to the Sharma--Mittal model over the long time limit only if in the latter case one of the three parameters describing Sharma--Mittal entropy $r$ depends on $\alpha$, and satisfies the specific equation derived in this paper, whereas the other two models mentioned above give different FTPs with the fractional model. Greens' functions obtained from the Sharma-Mittal and fractional models - for $r$ obtained from this particular equation - are very similar to each other. We will also discuss the interpretation of subdiffusion models based on nonadditive entropies and the possibilities of experimental measurement of subdiffusion models parameters.Comment: 12 pages, 8 figure