Versatile ytterbium ion trap experiment for operation of scalable ion-trap chips with motional heating and transition-frequency measurements

We present the design and operation of an ytterbium ion trap experiment with a setup offering versatile optical access and 90 electrical interconnects that can host advanced surface and multilayer ion trap chips mounted on chip carriers. We operate a macroscopic ion trap compatible with this chip carrier design and characterize its performance, demonstrating secular frequencies >1 MHz, and trap and cool nearly all of the stable isotopes, including 171Yb+ ions, as well as ion crystals. For this particular trap we measure the motional heating rate 〈ṅ〉 and observe an 〈ṅ〉∝1/ω2 behavior for different secular frequencies ω. We also determine a spectral noise density SE(1 MHz)=3.6(9)×10-11 V2 m-2 Hz-1 at an ion electrode spacing of 310(10) μm. We describe the experimental setup for trapping and cooling Yb+ ions and provide frequency measurements of the 2S1/2↔2P1/2 and 2D3/2↔3D[3/2]1/2 transitions for the stable 170Yb+, 171Yb+, 172Yb+, 174Yb+, and 176Yb+ isotopes which are more precise than previously published work

Gill Function in an Elasmobranch

Highly efficient oxygen uptake in elasmobranchs, as indicated by frequent excess of PaO2 over PEO2 has previously been ascribed to the operation of multicapillary rather than counter-current gas exchange by the gills. Analysis of models shows that, at maximum efficiency, a multicapillary system cannot account for values of PaO2 greater than (PIO2+PEO2)/2. In Port Jackson sharks Heterodontus portusjacksoni) PaO2 commonly exceeds (PIO2+PEO2)/2, which indicates the operation of a functional counter-current at the respiratory surface. The anatomical basis of this counter-current is provided by the demonstration that a continuous flow of water passes between the secondary lamellae into septal canals and thence via the parabranchial cavities to the exterior

No proof nets for MLL with units:Proof equivalence in MLL is PSPACE-complete

[Analysis of algorithms and problem complexity]: Nonnumerical algorithms and problems—Complexity of proof procedures Keywords linear logic, proof equivalence, proof nets, constraint logic, PSPACE-completeness MLL proof equivalence is the problem of deciding whether two proofs in multiplicative linear logic are related by a series of inference permutations. It is also known as the word problem for ∗-autonomous categories. Previous work has shown the problem to be equivalent to a rewiring problem on proof nets, which are not canonical for full MLL due to the presence of the two units. Drawing from recent work on reconfiguration problems, in this paper it is shown that MLL proof equivalence is PSPACE-complete, using a reduction from Nondeterministic Constraint Logic. An important consequence of the result is that the existence of a satisfactory notion of proof nets for MLL with units is ruled out (under current complexity assumptions). 1

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality

Background: Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry. Methods: Multiple Mendelian randomisation (MR) methods were used to test the relationship between (a) BMI and (b) waist-hip ratio (WHR) with depression. Firstly, we performed two-sample MR using genetic summary statistics from a recent genome-wide association study (GWAS) of depression (with 15,771 cases and 178,777 controls) in people of East Asian ancestry. We selected 838 single nucleotide polymorphisms (SNPs) correlated with BMI and 263 SNPs correlated with WHR as genetic instrumental variables to estimate the causal effect of BMI and WHR on depression using the inverse-variance weighted (IVW) method. We repeated these analyses stratifying by home location status: China versus UK or USA. Secondly, we performed one-sample MR in the China Kadoorie Biobank (CKB) in 100,377 participants. This allowed us to test the relationship separately in (a) males and females and (b) urban and rural dwellers. We also examined (c) the linearity of the BMI-depression relationship. Results: Both MR analyses provided evidence that higher BMI was associated with lower odds of depression. For example, a genetically-instrumented 1-SD higher BMI in the CKB was associated with lower odds of depressive symptoms [OR: 0.77, 95% CI: 0.63, 0.95]. There was evidence of differences according to place of residence. Using the IVW method, higher BMI was associated with lower odds of depression in people of East Asian ancestry living in China but there was no evidence for an association in people of East Asian ancestry living in the USA or UK. Furthermore, higher genetic BMI was associated with differential effects in urban and rural dwellers within China. Conclusions: This study provides the first MR evidence for an inverse relationship between BMI and depression in people of East Asian ancestry. This contrasts with previous findings in European populations and therefore the public health response to obesity and depression is likely to need to differ based on sociocultural factors for example, ancestry and place of residence. This highlights the importance of setting-specific causality when using genetic causal inference approaches and data from diverse populations to test hypotheses. This is especially important when the relationship tested is not purely biological and may involve sociocultural factors

Gene content evolution in the arthropods

Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods. Using 76 whole genome sequences representing 21 orders spanning more than 500 million years of arthropod evolution, we document changes in gene and protein domain content and provide temporal and phylogenetic context for interpreting these innovations. We identify many novel gene families that arose early in the evolution of arthropods and during the diversification of insects into modern orders. We reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene family and protein domain evolution coincident with the appearance of notable phenotypic and physiological adaptations such as flight, metamorphosis, sociality, and chemoperception. These analyses demonstrate how large-scale comparative genomics can provide broad new insights into the genotype to phenotype map and generate testable hypotheses about the evolution of animal diversity

Energy gain of wetted-foam implosions with auxiliary heating for inertial fusion studies

Low convergence ratio implosions (where wetted-foam layers are used to limit capsule convergence, achieving improved robustness to instability growth) and auxiliary heating (where electron beams are used to provide collisionless heating of a hotspot) are two promising techniques that are being explored for inertial fusion energy applications. In this paper, a new analytic study is presented to understand and predict the performance of these implosions. Firstly, conventional gain models are adapted to produce gain curves for fixed convergence ratios, which are shown to well-describe previously simulated results. Secondly, auxiliary heating is demonstrated to be well understood and interpreted through the burn-up fraction of the deuterium-tritium fuel, with the gradient of burn-up with respect to burn-averaged temperature shown to provide good qualitative predictions of the effectiveness of this technique for a given implosion. Simulations of auxiliary heating for a range of implosions are presented in support of this and demonstrate that this heating can have significant benefit for high gain implosions, being most effective when the burn-averaged temperature is between 5 and 20 keV

Loss of CIC promotes mitotic dysregulation and chromosome segregation defects

Background: CIC is a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, including gliomas, lung cancers, and gastric adenocarcinomas. CIC alterations and/or loss of CIC activity have been associated with poorer outcomes and more aggressive phenotypes across cancer types, which is consistent with the notion that CIC functions as a tumour suppressor across a wide range of contexts. Results: Using mammalian cells lacking functional CIC, we found that CIC deficiency was associated with chromosome segregation (CS) defects, resulting in chromosomal instability and aneuploidy. These CS defects were associated with transcriptional dysregulation of spindle assembly checkpoint and cell cycle regulators. We also identified novel CIC interacting proteins, including core members of the SWI/SNF complex, and showed that they cooperatively regulated the expression of genes involved in cell cycle regulation. Finally, we showed that loss of CIC and ARID1A cooperatively increased CS defects and reduced cell viability. Conclusions: Our study ascribes a novel role to CIC as an important regulator of the cell cycle and demonstrates that loss of CIC can lead to chromosomal instability and aneuploidy in human and murine cells through defects in CS, providing insight into the underlying mechanisms of CIC's increasingly apparent role as a "pan-cancer" tumour suppressor

Deep HST Observations of Star Clusters in NGC 1275

We present an analysis of compact star clusters in deep HST/WFPC2 images of NGC 1275. B and R band photometry of roughly 3000 clusters shows a bimodality in the B-R colors, suggesting that distinct old and young cluster populations are present. The small spread in the colors of the blue clusters is consistent with the hypothesis that they are a single age population, with an inferred age of 0.1 to 1 Gyr. The luminosity function shows increasing numbers of blue clusters to the limit of our photometry, which reaches several magnitudes past the turnover predicted if the cluster population were identical to current Galactic globulars seen at a younger age. The blue clusters have a spatial distribution which is more centrally peaked than that of the red clusters. The individual clusters are slightly resolved, with core radii <~ 0.75 pc if they have modified Hubble profiles. We estimate the specific frequencies of the old and young populations and discuss the uncertainties in these estimates. We find that the specific frequency of the young population in NGC 1275 is currently larger than that of the old population and will remain so as the young population evolves, even if the majority of the low mass clusters are eventually destroyed. If the young population formed during a previous merger, this suggests that mergers can increase the specific frequency of globulars in a galaxy. However, the presently observed young population likely contains too few clusters to have a significant impact on the overall specific frequency as it will be observed in the future.Comment: 26 pages, 9 figures, to be published in the Astronomical Journa

Bending the curve of global freshwater biodiversity loss: an emergency recovery plan

Despite their limited spatial extent, freshwater ecosystems host remarkable biodiversity, including one-third of all vertebrate species. This biodiversity is declining dramatically: Globally, wetlands are vanishing three times faster than forests, and freshwater vertebrate populations have fallen more than twice as steeply as terrestrial or marine populations. Threats to freshwater biodiversity are well documented but coordinated action to reverse the decline is lacking. We present an Emergency Recovery Plan to bend the curve of freshwater biodiversity loss. Priority actions include accelerating implementation of environmental flows; improving water quality; protecting and restoring critical habitats; managing the exploitation of freshwater ecosystem resources, especially species and riverine aggregates; preventing and controlling nonnative species invasions; and safeguarding and restoring river connectivity. We recommend adjustments to targets and indicators for the Convention on Biological Diversity and the Sustainable Development Goals and roles for national and international state and nonstate actors