Is Prison Why I’m sick? Examining Health Conditions Among Minority Males Within Correctional Facilities

Given the current United States prison population of 1.5 million persons, many states have begun to examine how to effectively reduce correctional expenditures, considering in 2011 healthcare related prison costs increased to approximately eight billion (The Pew Charitable Trusts, 2014). Recent research attributes much of this increase to the prevalence of disease and aging within the prison population (Williams et al., 2012; Dumont et al., 2012; Gallagher, 2001; Ahalt et al., 2013). Alternatively, little attention has been devoted to measuring the disparity in health among minority male inmates or the effects of identifying more cost effective health initiatives that address negative health outcomes. With incarceration and health expenditures rates steadily increasing within the United States, studies have highlighted the positive correlation between incarceration and the costs of inmate health, as well as the implications associated with physical illness and its overarching effects on the performance of correctional health care. This study represents an attempt at bridging the gap between preventative health care and criminal justice efforts within the literature in its examination of the demographics, history of incarceration, chronic illness, and current medical conditions of minority male inmates within the state correctional facilities

Chemical profiling and biotechnological potential of marine microalgae in response to light and abiotic stress

Microalgae form the base of the aquatic food chain and have important ecological functions, including nutrient cycling and carbon capturing. These microscopic eukaryotes are incredibly diverse, with an estimated 72,000 extant species. They have been investigated for their biotechnological potential in industries such as nutraceutical, cosmetic, and biofuel. Most research has focused on specific high-value metabolites such as astaxanthin or β-carotene for human health, or classes of natural products such as polyunsaturated fatty acids for biofuels. However, a systematic untargeted approach to exploring the chemical diversity of microalgal metabolites has yet to be performed. Unlocking this chemical potential could provide further applications and incentives to the microalgal biotechnology sector. This thesis aims to fill this gap by exploring the chemical space of microalgae and the elicitation of further chemistry using abiotic stress. A comparative metabolomics study of 36 microalgal strains from both freshwater and marine environments showed that Haptophytes were a rich source of chemistry compared to the well-studied Chlorophytes. It also explored chemical diversity across strains of the same species, providing evidence that isolation environment rather than phylogenetic relationships could be used to group microalgae based on chemical profiles. To investigate the chemistry produced by three strains of marine microalgae, Dunaliella primolecta, Nannochloropsis oculata, and Phaeodactylum tricornutum were cultured under varying conditions of salinity, sodium chloride, nitrate, and pH and Global Natural Products Social (GNPS) molecular networking was used to gain insights into the effect of these stresses on metabolite production. A total of 2284 metabolites were detected across all strains and conditions, with 49% of those metabolites specific to cultures grown under stress conditions (i.e., not in the control). Salinity had the greatest effect with 22.8% of metabolites only produced under salinity stress. From comparison with over 33 libraries of mass spectral data, only five metabolites were identified, stressing the need for more open-access natural product -and specifically algal natural product - databases. Finally, we partnered with Xanthella Ltd., a marine biotechnology company in Scotland, to study the effect of 405 nm light on growth of four strains of microalgae and the production of antimicrobial metabolites. This wavelength has been shown to reduce bacterial contamination in cultures but is an expensive regimen to apply at a large scale. The production of high-value metabolites under this light regimen could enable culturing under 405 nm illumination to be economically viable. Although no bioactivity was observed from extracts or fractions, molecular networking did show that 16-25% of metabolites were either exclusively produced under 405 nm illumination or absent from the white light control condition. This thesis offers a starting point for fundamental and comparative research into microalgal growth and metabolite production and their applications in human health.Microalgae form the base of the aquatic food chain and have important ecological functions, including nutrient cycling and carbon capturing. These microscopic eukaryotes are incredibly diverse, with an estimated 72,000 extant species. They have been investigated for their biotechnological potential in industries such as nutraceutical, cosmetic, and biofuel. Most research has focused on specific high-value metabolites such as astaxanthin or β-carotene for human health, or classes of natural products such as polyunsaturated fatty acids for biofuels. However, a systematic untargeted approach to exploring the chemical diversity of microalgal metabolites has yet to be performed. Unlocking this chemical potential could provide further applications and incentives to the microalgal biotechnology sector. This thesis aims to fill this gap by exploring the chemical space of microalgae and the elicitation of further chemistry using abiotic stress. A comparative metabolomics study of 36 microalgal strains from both freshwater and marine environments showed that Haptophytes were a rich source of chemistry compared to the well-studied Chlorophytes. It also explored chemical diversity across strains of the same species, providing evidence that isolation environment rather than phylogenetic relationships could be used to group microalgae based on chemical profiles. To investigate the chemistry produced by three strains of marine microalgae, Dunaliella primolecta, Nannochloropsis oculata, and Phaeodactylum tricornutum were cultured under varying conditions of salinity, sodium chloride, nitrate, and pH and Global Natural Products Social (GNPS) molecular networking was used to gain insights into the effect of these stresses on metabolite production. A total of 2284 metabolites were detected across all strains and conditions, with 49% of those metabolites specific to cultures grown under stress conditions (i.e., not in the control). Salinity had the greatest effect with 22.8% of metabolites only produced under salinity stress. From comparison with over 33 libraries of mass spectral data, only five metabolites were identified, stressing the need for more open-access natural product -and specifically algal natural product - databases. Finally, we partnered with Xanthella Ltd., a marine biotechnology company in Scotland, to study the effect of 405 nm light on growth of four strains of microalgae and the production of antimicrobial metabolites. This wavelength has been shown to reduce bacterial contamination in cultures but is an expensive regimen to apply at a large scale. The production of high-value metabolites under this light regimen could enable culturing under 405 nm illumination to be economically viable. Although no bioactivity was observed from extracts or fractions, molecular networking did show that 16-25% of metabolites were either exclusively produced under 405 nm illumination or absent from the white light control condition. This thesis offers a starting point for fundamental and comparative research into microalgal growth and metabolite production and their applications in human health

Black Hearts Matter: A Comparative Study of Sociodemographic, Clinical, and Psychosocial Characteristics in Black and White Persons With Heart Failure

Heart failure (HF) is a chronic, progressive, debilitating illness that disproportionately affects Black individuals, often leading to poor quality of life (QOL). Various sociodemographic, clinical, and psychological characteristics are related to QOL in patients with HF. Because most studies do not include representative Black samples or report findings from racial subgroup analyses, these relationships and any existing racial differences are not well understood. The purpose of this descriptive, comparative study was to explore the relationships among sociodemographic, clinical, and psychological characteristics and QOL in patients with HF and to determine if there were racial differences between Black and White individuals. Mean participant age was 56.29 (SD = 12.42). SPSS 27.0 was the program used to conduct secondary data analysis. Among the sociodemographic characteristics, racial differences were apparent in age, gender, and marital status. Racial differences in ejection fraction, New York Heart Association Classification, comorbidities, and functional status emerged as clinical characteristics. Race was not significantly associated with QOL. Physical functioning and anxiety were significant predictors of QOL in the initial analysis. However, in the full model, older age and greater depression remained significant, suggesting they were the strongest predictors of QOL. Patients with HF should undergo regular screening for depression and anxiety. Future researchers should explore sociodemographic, clinical, and psychological characteristics in larger samples; consider the timing and measurement approaches for depression, anxiety, and QOL; and further explore racial differences

Pleistocene plateau ice fields in the High Atlas, Morocco

Large ice fields (>25 km² ) formed over the Tazaghart and Iouzagner plateaux of the High Atlas, Morocco, during the Late Pleistocene. The plateau ice fields were drained by large valley glaciers forming a series of moraine assemblages. Four moraine units have been mapped and subdivided on the basis of morphostratigraphy and the degree of soil weathering. Soil profile development index (PDI) values indicate that the moraine units are widely separated in time with the oldest moraines deeply weathered and degraded whereas soils are absent on the youngest moraines. The highest moraine unit was formed by a small niche glacier which was present as recently as the mid 20th Century. Pleistocene glaciers are likely to have been associated with wetter conditions than today in addition to colder air temperatures. Combined with ice in neighbouring areas, such as the Toubkal Massif, the SW High Atlas supported some of the largest glaciers in Africa during the Pleistocene. The extent of glaciation with ice exploiting and breaching drainage divides has major implications for landscape development. The evolution of the High Atlas is therefore strongly shaped by glaciation and this is closely intertwined with tectonic, fluvial and slope processes

Moral Injury among Transplant Providers: Evaluating the Effects of Training in End-of-Life Counseling

Introduction. Ethical issues are pervasive in healthcare, but few specialties rival the moral complexity of transplant medicine. Transplant providers must regularly inform patients that they are no longer eligible to receive a potentially life-saving operation and the stress of these conversations poses a high risk of moral injury. Training in end of life counseling (EOLC) has been shown to significantly reduce provider stress and burnout. We hypothesized that training in EOLC reduces levels of moral injury among transplant providers.   Methods. This was a mixed methods study. A survey was administered to staff in the solid organ transplant department at the University of Kansas Health System. Providers indicated whether they had received training in EOLC and completed the standardized Moral Injury Symptom Scale-Healthcare Professionals version (MISS-HP). A two-sample, one-sided t-test compared levels of moral injury between trained and untrained staff. Subsequently, semi-structured interviews were conducted with transplant providers, and inductive coding followed by thematic network analysis was performed.  Results. Thirty-seven percent of respondents reported a moral injury score at or above the threshold for psychosocial dysfunctioning associated with moral injury. Analysis revealed no difference in moral injury scores between the trained and untrained groups (p=0.362, power=0.842). Ten participants were interviewed. Thematic network analysis demonstrated high-level themes of “challenges”, “training” and “stress relief”.   Conclusions. Our study demonstrated a concerning prevalence of moral injury among transplant providers and suggested that EOLC training does not significantly mitigate the threat of moral injury

Climbing the value chain: strategies to create a new product development capability in mature SMEs

PURPOSE. Increasing productivity gaps and declining manufacturing bases create complex challenges for mature small to medium enterprises (SMEs). One solution advocated by academia is to reposition along the value chain – moving to a position of greater value. The purpose of this paper is to examine strategies used by firms to reposition through creating a new product development (NPD) capability. In doing so, the paper seeks to resolve gaps in extant literature on NPD in mature SMEs. DESIGN/METHODOLOGY/APPROACH. An exploratory approach is taken, analysing in‐depth case studies of three mature UK manufacturing SMEs. FINDINGS. Four strategic approaches to enable the creation of a NPD capability (strategic alliances, licensing key technologies and ideas, outsourcing and deploying an internal development process) are found. Each may facilitate an SME to reposition but the findings highlight that these strategies are not mutually exclusive as different combinations were employed to accelerate and leverage change. RESEARCH LIMITATIONS/IMPLICATIONS. Limited number of case studies constrains wider understanding despite providing richness. The findings highlight four different strategies for repositioning but there may be other routes. PRACTICAL IMPLICATIONS. Deeper understanding of how to climb the value chain, providing valuable lessons for mature SMEs facing a need to reposition to generate new growth opportunities. ORIGINALITY/VALUE. The paper provides an understanding of how mature manufacturers utilise different strategies to overcome resource constraints and generate a NPD capability to assist in repositioning. This resolves weaknesses in current literature that so far have not adequately examined the process of shaping a NPD capability and the strategies used to reposition

The structure and petrology of the Cnoc nan Cuilean Intrusion, Loch Loyal Syenite Complex, NW Scotland

In NW Scotland, several alkaline intrusive complexes of Silurian age intrude the Caledonian orogenic front. The most northerly is the Loch Loyal Syenite Complex, which is divided into three separate intrusions (Ben Loyal, Beinn Stumanadh and Cnoc nan Cuilean). Mapping of the Cnoc nan Cuilean intrusion shows two main zones: a Mixed Syenite Zone (MZ) and a Massive Leucosyenite Zone (LZ), with a gradational contact. The MZ forms a lopolith, with multiple syenitic lithologies, including early basic melasyenites and later felsic leucosyenites. Leucosyenite melts mixed and mingled with melasyenites, resulting in extreme heterogeneity within the MZ. Continued felsic magmatism resulted in formation of the relatively homogeneous LZ, invading western parts of the MZ and now forming the topographically highest terrane. The identification of pegmatites, microgranitic veins and unusual biotite-magnetite veins demonstrates the intrusion's complex petrogenesis. Cross-sections have been used to create a novel 3D GoCad™ model contributing to our understanding of the intrusion. The Loch Loyal Syenite Complex is known to have relatively high concentrations of rare earth elements (REEs), and thus the area has potential economic and strategic value. At Cnoc nan Cuilean, abundant REE-bearing allanite is present within melasyenites of the MZ. Extensive hydrothermal alteration of melasyenites here formed steeply dipping biotite-magnetite veins, most enriched in allanite and other REE-bearing accessories. This study has thus identified the area of greatest importance for further study of REE enrichment processes in the Cnoc nan Cuilean intrusion