EVALUATING THE IMPACTS OF AGRICULTURAL EXPORTS ON A REGIONAL ECONOMY

Agricultural exports are important to many regional economies, as is the case for agricultural exports wither produced in or shipped through Louisiana. A hybrid (revised and verified) IMPLAN model of the Louisiana economy is used to estimate the direct and indirect impact of agricultural exports. Original model estimates of foreign exports lacked holistic (overall) accuracy. However, other, more general uses of the model were unaffected by this lack of accuracy. While the contributions of agricultural exports to the state economy were substantial, impacts were concentrated in unprocessed products. Increasing the export of processed agricultural products should enhance economic activity.Agricultural exports, Holistic accuracy, IMPLAN, Input-output models, Processed exports, Community/Rural/Urban Development, International Relations/Trade,

Central nervous system targets: inhibitory interneurons in the spinal cord

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an adaptive function by helping us respond appropriately in a potentially hostile environment and also a protective role by alerting us to tissue damage. Normally, it is evoked by the activation of peripheral nociceptive nerve endings and the subsequent relay of information to distinct cortical and sub-cortical regions, but under pathological conditions that result in chronic pain, it can become spontaneous. Given that one in three chronic pain patients do not respond to the treatments currently available, the need for more effective analgesics is evident. Two principal obstacles to the development of novel analgesic therapies are our limited understanding of how neuronal circuits that comprise these pain pathways transmit and modulate sensory information under normal circumstances and how these circuits change under pathological conditions leading to chronic pain states. In this review, we focus on the role of inhibitory interneurons in setting pain thresholds and, in particular, how disinhibition in the spinal dorsal horn can lead to aberrant sensory processing associated with chronic pain states

Rewards, perils and pitfalls of untangling spinal pain circuits

Pain is a complex perception that is fundamental to our daily survival. Under normal circumstances, it serves an important protective function to guard against tissue damage or alert the body to dangerous environments. Under pathological states, however, the perception of pain can become chronic, maladaptive, resistant to treatment, and presents a serious clinical and societal problem. A wealth of literature suggests that disruption of sensory processing within the spinal cord contributes to chronic pain, but our limited understanding of spinal circuitry in health and disease remains a barrier to the development of new therapeutic strategies. The aim of this brief review is to outline current thinking about how individual components of functionally-distinct spinal microcircuits can be identified and manipulated to determine their role in influencing our perception of pain in acute and chronic states

Evaluting the Impact of Agricultural Exports on the Louisiana Economy (Bulletin #852)

A revised hybrid IMPLAN model of the Louisiana economy, based on its structure in 1985, was used to estimate the impact of agricultural exports on the state economy. This publication includes the results of the model, which should be useful to state policy makers and others concerned about the ability of foreign markets to generate economic activity in Louisiana.https://digitalcommons.lsu.edu/agcenter_bulletins/1047/thumbnail.jp

Double-impulse magnetic focusing of launched cold atoms.

We have theoretically investigated three-dimensional focusing of a launched cloud of cold atoms using a pair of magnetic lens pulses (the alternate-gradient method). Individual lenses focus radially and defocus axially or vice versa. The performance of the two possible pulse sequences are compared and found to be ideal for loading both 'pancake' and 'sausage' shaped magnetic/optical microtraps. It is shown that focusing aberrations are considerably smaller for double-impulse magnetic lenses compared to single-impulse magnetic lenses. An analysis of clouds focused by the double-impulse technique is presented

A class of Lorentzian Kac-Moody algebras

We consider a natural generalisation of the class of hyperbolic Kac-Moody algebras. We describe in detail the conditions under which these algebras are Lorentzian. We also construct their fundamental weights, and analyse whether they possess a real principal so(1,2) subalgebra. Our class of algebras include the Lorentzian Kac-Moody algebras that have recently been proposed as symmetries of M-theory and the closed bosonic string.Comment: 40 pages TeX, 5 eps-figure

Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation

Background: Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal models of axial pain are not widely available. Accordingly, we developed a mouse model of acute cervical muscle inflammation and assessed the functional properties of superficial dorsal horn (SDH) neurons.<p></p> Results: Male C57/Bl6 mice (P24-P40) were deeply anaesthetised (urethane 2.2?g/kg i.p) and the rectus capitis major muscle (RCM) injected with 40??l of 2% carrageenan. Sham animals received vehicle injection and controls remained anaesthetised for 2?hrs. Mice in each group were sacrificed at 2?hrs for analysis. c-Fos staining was used to determine the location of activated neurons. c-Fos labelling in carrageenan-injected mice was concentrated within ipsilateral (87% and 63% of labelled neurons in C1 and C2 segments, respectively) and contralateral laminae I - II with some expression in lateral lamina V. c-Fos expression remained below detectable levels in control and sham animals. In additional experiments, whole cell recordings were obtained from visualised SDH neurons in transverse slices in the ipsilateral C1 and C2 spinal segments. Resting membrane potential and input resistance were not altered. Mean spontaneous EPSC amplitude was reduced by ~20% in neurons from carrageenan-injected mice versus control and sham animals (20.63???1.05 vs. 24.64???0.91 and 25.87???1.32 pA, respectively). The amplitude (238???33 vs. 494???96 and 593???167 pA) and inactivation time constant (12.9???1.5 vs. 22.1???3.6 and 15.3???1.4?ms) of the rapid A type potassium current (IAr), the dominant subthreshold current in SDH neurons, were reduced in carrageenan-injected mice.<p></p> Conclusions: Excitatory synaptic drive onto, and important intrinsic properties (i.e., IAr) within SDH neurons are reduced two hours after acute muscle inflammation. We propose this time point represents an important transition period between peripheral and central sensitisation with reduced excitatory drive providing an initial neuroprotective mechanism during the early stages of the progression towards central sensitisation

Anatomical and molecular properties of long descending propriospinal neurons in mice

Long descending propriospinal neurons (LDPNs) are interneurons that form direct connections between cervical and lumbar spinal circuits. LDPNs are involved in interlimb coordination and are important mediators of functional recovery after spinal cord injury (SCI). Much of what we know about LDPNs comes from a range of species, however, the increased use of transgenic mouse lines to better define neuronal populations calls for a more complete characterisation of LDPNs in mice. In this study, we examined the cell body location, inhibitory neurotransmitter phenotype, developmental provenance, morphology and synaptic inputs of mouse LDPNs throughout the cervical and upper thoracic spinal cord. LDPNs were retrogradely labelled from the lumbar spinal cord to map cell body locations throughout the cervical and upper thoracic segments. Ipsilateral LDPNs were distributed throughout the dorsal, intermediate and ventral grey matter as well as the lateral spinal nucleus and lateral cervical nucleus. In contrast, contralateral LDPNs were more densely concentrated in the ventromedial grey matter. Retrograde labelling in GlyT2GFP and GAD67GFP mice showed the majority of inhibitory LDPNs project either ipsilaterally or adjacent to the midline. Additionally, we used several transgenic mouse lines to define the developmental provenance of LDPNs and found that V2b positive neurons form a subset of ipsilaterally projecting LDPNs. Finally, a population of Neurobiotin (NB) labelled LDPNs were assessed in detail to examine morphology and plot the spatial distribution of contacts from a variety of neurochemically distinct axon terminals. These results provide important baseline data in mice for future work on their role in locomotion and recovery from SCI

The search for novel analgesics: re-examining spinal cord circuits with new tools

In this perspective, we propose the absence of detailed information regarding spinal cord circuits that process sensory information remains a major barrier to advancing analgesia. We highlight recent advances showing that functionally discrete populations of neurons in the spinal cord dorsal horn play distinct roles in processing sensory information. We then discuss new molecular, electrophysiological, and optogenetic techniques that can be employed to understand how dorsal horn circuits process tactile and nociceptive information. We believe this information can drive the development of entirely new classes of pharmacotherapies that target key elements in spinal circuits to selectively modify sensory function and blunt pain

The Disk Substructures at High Angular Resolution Project (DSHARP). III. Spiral Structures in the Millimeter Continuum of the Elias 27, IM Lup, and WaOph 6 Disks

We present an analysis of Atacama Large Millimeter/submillimeter Array 1.25 mm continuum observations of spiral structures in three protoplanetary disks from the Disk Substructures at High Angular Resolution Project. See full text for full abstract