11,860 research outputs found
Sound insulation design of modular construction housing
This paper provides an insight into the acoustic issues of modular housing using the Verbus System of construction. The paper briefly summarises the history of the development of Verbus modular housing and the acoustic design considerations of the process. Results are presented from two sound insulation tests conducted during the course of the project. The results are discussed in terms of compliance with Approved Document E1 and increased performance standards such as EcoHomes2
The status of environmental satellites and availability of their data products
The latest available information about the status of unclassified environmental satellite (flown by the United States) and their data products is presented. The type of environmental satellites discussed include unmanned earth resource and meteorological satellites, and manned satellites which can act as a combination platform for instruments. The capabilities and data products of projected satellites are discussed along with those of currently operating systems
2-Dimensional vector invariants of parabolic subgroups of Gl2(Fp) over the field Fp
AbstractGiven a group G acting on a finite dimensional vector space V over any field k, we ask for the structure of the ring of invariants of the diagonal action of the group on the symmetric algebra of m copies of V, the so-called m-dimensional vector invariants of G. In this paper we use elementary techniques to determine the structure of the 2-dimensional vector invariants of Gl2(FP), Sl2(FP), U2(FP) acting as usual on a vector space of dimension 2 over FP. We know that these rings of invariants are Cohen-Macaulay and we compute for each a free module basis over a suitably chosen homogeneous system of parameters
3D attributed models for addressing environmental and engineering geoscience problems in areas of urban regeneration : a case study in Glasgow, UK
The City of Glasgow is situated on and around the lower floodplain and inner estuary of the River Clyde in the west of Scotland, UK. Glasgow’s urban hinterland once was one of Europe’s leading centres of heavy industry, and of ship building in particular. The industries were originally fed by locally mined coal and ironstone. In common with many European cities, the heavy industries declined and Glasgow was left with a legacy of industrial dereliction, widespread undermining, and extensive vacant and contaminated sites, some the infilled sites of clay pits and sand and gravel workings
Infection-acquired versus vaccine-acquired immunity in an SIRWS model
Despite high vaccine coverage, pertussis has re-emerged as a public health
concern in many countries. One hypothesis posed for re-emergence is the waning
of immunity. In some disease systems, the process of waning immunity can be
non-linear, involving a complex relationship between the duration of immunity
and subsequent boosting of immunity through asymptomatic re-exposure.
We present and analyse a model of infectious disease transmission to examine
the interplay between infection and immunity. By allowing the duration of
infection-acquired immunity to differ from that of vaccine-acquired immunity,
we explore the impact of the difference in durations on long-term disease
patterns and prevalence of infection.
Our model demonstrates that vaccination may induce cyclic behaviour, and its
ability to reduce the infection prevalence increases with both the duration of
infection-acquired immunity and duration of vaccine-acquired immunity. We find
that increasing vaccine coverage, while capable of leading to an increase in
overall transmission, always results in a reduction in prevalence of primary
infections, with epidemic cycles characterised by a longer interepidemic period
and taller peaks.
Our results show that the epidemiological patterns of an infectious disease
may change considerably when the duration of vaccine-acquired immunity differs
from that of infection-acquired immunity. Our study highlights that for any
particular disease and associated vaccine, a detailed understanding of the
duration of protection and how that duration is influenced by infection
prevalence is important as we seek to optimise vaccination strategies.Comment: 21 pages, 5 figure
Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals,
there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death
receptors’ such as Fas/APO-1; and the ‘intrinsic’ pathway, which is triggered by diverse cellular stresses, and is regulated by prosurvival
and pro-apoptotic members of the Bcl-2 family of proteins. Pro-survival Mcl-1, which can block activation of the proapoptotic
proteins, Bax and Bak, appears critical for the survival and maintenance of multiple haemopoietic cell types. To
investigate the impact on haemopoiesis of simultaneously inhibiting both apoptosis pathways, we introduced the vavP-Mcl-1
transgene, which causes overexpression of Mcl-1 protein in all haemopoietic lineages, into Faslpr/lpr mice, which lack functional
Fas and are prone to autoimmunity. The combined mutations had a modest impact on myelopoiesis, primarily an increase in the
macrophage/monocyte population in Mcl-1tg/lpr mice compared with lpr or Mcl-1tg mice. The impact on lymphopoiesis was
striking, with a marked elevation in all major lymphoid subsets, including the non-conventional double-negative (DN) T cells
(TCRβ+
CD4–
CD8–
B220+
) characteristic of Faslpr/lpr mice. Of note, the onset of autoimmunity was markedly accelerated in Mcl-1tg/lpr
mice compared with lpr mice, and this was preceded by an increase in immunoglobulin (Ig)-producing cells and circulating
autoantibodies. This degree of impact was surprising, given the relatively mild phenotype conferred by the vavP-Mcl-1 transgene
by itself: a two- to threefold elevation of peripheral B and T cells, no significant increase in the non-conventional DN T-cell
population and no autoimmune disease. Comparison of the phenotype with that of other susceptible mice suggests that the
development of autoimmune disease in Mcl-1tg/lpr mice may be influenced not only by Ig-producing cells but also other
haemopoietic cell types
Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance.
Since 2015 in the United States (US), the US Neisseria meningitidis urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males. Its 'parent' strain caused numerous outbreaks of invasive meningococcal disease among men who have sex with men in Europe and North America. We highlight the arrival and dissemination of US_NmUC in the United Kingdom and the emergence of multiple antibiotic resistance. Surveillance systems should be developed that include anogenital meningococci
Reducing smoking in adolescents: cost-effectiveness results from the cluster randomized ASSIST (A Stop Smoking In Schools Trial)
Introduction: School-based smoking prevention programmes can be effective, but evidence on cost-effectiveness is lacking. We conducted a cost-effectiveness analysis of a school-based “peer-led” intervention.<p></p>
Methods: We evaluated the ASSIST (A Stop Smoking In Schools Trial) programme in a cluster randomized controlled trial. The ASSIST programme trained students to act as peer supporters during informal interactions to encourage their peers not to smoke. Fifty-nine secondary schools in England and Wales were randomized to receive the ASSIST programme or usual smoking education. Ten thousand seven hundred and thirty students aged 12–13 years attended participating schools. Previous work has demonstrated that the ASSIST programme achieved a 2.1% (95% CI = 0%–4.2%) reduction in smoking prevalence. We evaluated the public sector cost, prevalence of weekly smoking, and cost per additional student not smoking at 24 months.<p></p>
Results: The ASSIST programme cost of £32 (95% CI = £29.70–£33.80) per student. The incremental cost per student not smoking at 2 years was £1,500 (95% CI = £669–£9,947). Students in intervention schools were less likely to believe that they would be a smoker at age 16 years (odds ratio [OR] = 0.80; 95% CI = 0.66–0.96).<p></p>
Conclusions: A peer-led intervention reduced smoking among adolescents at a modest cost. The intervention is cost-effective under realistic assumptions regarding the extent to which reductions in adolescent smoking lead to lower smoking prevalence and/or earlier smoking cessation in adulthood. The annual cost of extending the intervention to Year 8 students in all U.K. schools would be in the region of £38 million and could result in 20,400 fewer adolescent smokers.<p></p>
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