The book publishing industry in Japan and the UK: corporate philosohpy/objectives, behaviour and market structure

A number of prominent publishers in the UK and US have become parts of globalized media groups. In Japan, by contrast, they have neither been absorbed into media groups nor become globalized businesses. Based on interviews of major players in the Japanese publishing industry as well as annual reports, other written materials, and in comparison with the UK, this paper examines co-relationships among corporate philosophy, behaviour, and market structure with a view to explaining comparative divergence between Japan and the UK.publishing industry, corporate philosophy, corporate behaviour, ownership

Galaxy Nurseries: Crowdsourced analysis of slitless spectroscopic data

We present the results of Galaxy Nurseries project, which was designed to enable crowdsourced analysis of slitless spectroscopic data by volunteer citizen scientists using the Zooniverse online interface. The dataset was obtained by the WFC3 Infrared Spectroscopic Parallel (WISP) Survey collaboration and comprises NIR grism (G102 and G141) and direct imaging. Volunteers were instructed to evaluate indicated spectral features and decide whether it was a genuine emission line or more likely an artifact. Galaxy Nurseries was completed in only 40 days, gathering 414,360 classifications from 3003 volunteers for 27,333 putative emission lines. The results of Galaxy Nurseries demonstrate the feasibility of identifying genuine emission lines in slitless spectra by citizen scientists. Volunteer responses for each subject were aggregated to compute $f_{\mathrm{Real}}$, the fraction of volunteers who classified the corresponding emission line as "Real". To evaluate the accuracy of volunteer classifications, their aggregated responses were compared with independent assessments provided by members of the WISP Survey Science Team (WSST). Overall, there is a broad agreement between the WSST and volunteers' classifications, although we recognize that robust scientific analyses typically require samples with higher purity and completeness than raw volunteer classifications provide. Nonetheless, choosing optimal threshold values for $f_{\mathrm{Real}}$ allows a large fraction of spurious lines to be vetoed, substantially reducing the timescale for subsequent professional analysis of the remaining potential lines.Comment: Accepted for publication in Research Notes of the AA

A New Microlensing Event in the Doubly-Imaged Quasar Q0957+561

We present evidence for ultraviolet/optical microlensing in the gravitationally lensed quasar Q0957+561. We combine new measurements from our optical monitoring campaign at the United States Naval Observatory, Flagstaff (USNO) with measurements from the literature and find that the time-delay-corrected r-band flux ratio m_A - m_B has increased by ~0.1 magnitudes over a period of five years beginning in the fall of 2005. We apply our Monte Carlo microlensing analysis procedure to the composite light curves, obtaining a measurement of the optical accretion disk size, log {(r_s/cm)[cos(i)/0.5]^{1/2}} = 16.2^{+0.5}_{-0.6}, that is consistent with the quasar accretion disk size - black hole mass relation.Comment: Replaced with accepted version. Minor adjustments to text but conclusions unchanged. Data in Table 2 have been updated and table now includes additional observation

Western Indian Ocean marine and terrestrial records of climate variability: a review and new concepts on land-ocean interactions since AD 1660

We examine the relationship between three tropical and two subtropical western Indian Ocean coral oxygen isotope time series to surface air temperatures (SAT) and rainfall over India, tropical East Africa and southeast Africa. We review established relationships, provide new concepts with regard to distinct rainfall seasons, and mean annual temperatures. Tropical corals are coherent with SAT over western India and East Africa at interannual and multidecadal periodicities. The subtropical corals correlate with Southeast African SAT at periodicities of 16–30 years. The relationship between the coral records and land rainfall is more complex. Running correlations suggest varying strength of interannual teleconnections between the tropical coral oxygen isotope records and rainfall over equatorial East Africa. The relationship with rainfall over India changed in the 1970s. The subtropical oxygen isotope records are coherent with South African rainfall at interdecadal periodicities. Paleoclimatological reconstructions of land rainfall and SAT reveal that the inferred relationships generally hold during the last 350 years. Thus, the Indian Ocean corals prove invaluable for investigating land–ocean interactions during past centuries

Correction to: Eight years after an international workshop on myotonic dystrophy patient registries: Case study of a global collaboration for a rare disease (Orphanet Journal of Rare Diseases (2018) 13 (155) DOI: 10.1186/s13023-018-0889-0)

The original version of this article [1] unfortunately included an error to an author\u27s name. Author Jordi Díaz-Manera was erroneously presented as Jorge Alberto Diaz Manera. The correct author name has been included in the author list of this Correction article. For citation purposes the author\u27s given name is Jordi and family name Diaz-Manera. Therefore, the correct citation of the author\u27s details is: Diaz-Manera J

Galaxy Nurseries: Crowdsourced Analysis of Slitless Spectroscopic Data

The Galaxy Nurseries project was designed to enable crowdsourced analysis of slitless spectroscopic data by volunteers using the Zooniverse online interface. The data set was obtained by the WFC3 Infrared Spectroscopic Parallel (WISP) Survey collaboration (Atek et al. 2010) and comprises NIR grism (G102 and G141) and direct imaging of 432 fields. The scientific goals of WISP Survey require reliable identification of emission lines (e.g., Atek et al. 2014; Masters et al. 2014). Spectral contamination by overlapping signals from multiple sources or diffraction orders as well as residual artifacts of the data reduction can significantly complicate the automatic detection and identification of emission lines. Visual verification of automatically detected features has proved essential to obtain a pure sample of emission lines. In Galaxy Nurseries verification of putative emission lines was delegated to citizen-scientist volunteers. Data were presented as "subject images" using the fixed format illustrated in the top panels of Figure 1. For each target, volunteers were provided with the two-dimensional spectrum (B), the corresponding one-dimensional extraction (A) and its direct image (C). Volunteers were instructed to evaluate only the feature identified by the green crosshairs and to decide whether it was a genuine emission line or more likely an artifact, providing a Boolean Valued (i.e., "Real" or "Spurious") label. Following its launch, Galaxy Nurseries was completed in only 40 days, gathering 414,360 classifications from 3003 volunteers for 27,333 putative emission lines. At least 15 classifications were obtained for each subject image. For reference, it took approximately 4.5 months for the full sample of lines to be visually inspected by two members of the WISP Survey Science Team (WSST)

Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders

Funder: GlaxoSmithKlineFunder: Janssen Research & Development, LLCAbstract: Activation of the innate immune system is commonly associated with depression. Immunomodulatory drugs may have efficacy for depressive symptoms that are co-morbidly associated with inflammatory disorders. We report a large-scale re-analysis by standardized procedures (mega-analysis) of patient-level data combined from 18 randomized clinical trials conducted by Janssen or GlaxoSmithKline for one of nine disorders (N = 10,743 participants). Core depressive symptoms (low mood, anhedonia) were measured by the Short Form Survey (SF-36) or the Hospital Anxiety and Depression Scale (HADS), and participants were stratified into high (N = 1921) versus low-depressive strata based on baseline ratings. Placebo-controlled change from baseline after 4–16 weeks of treatment was estimated by the standardized mean difference (SMD) over all trials and for each subgroup of trials targeting one of 7 mechanisms (IL-6, TNF-α, IL-12/23, CD20, COX2, BLγS, p38/MAPK14). Patients in the high depressive stratum showed modest but significant effects on core depressive symptoms (SMD = 0.29, 95% CI [0.12–0.45]) and related SF-36 measures of mental health and vitality. Anti-IL-6 antibodies (SMD = 0.8, 95% CI [0.20–1.41]) and an anti-IL-12/23 antibody (SMD = 0.48, 95% CI [0.26–0.70]) had larger effects on depressive symptoms than other drug classes. Adjustments for physical health outcome marginally attenuated the average treatment effect on depressive symptoms (SMD = 0.20, 95% CI: 0.06–0.35), but more strongly attenuated effects on mental health and vitality. Effects of anti-IL-12/23 remained significant and anti-IL-6 antibodies became a trend after controlling for physical response to treatment. Novel immune-therapeutics can produce antidepressant effects in depressed patients with primary inflammatory disorders that are not entirely explained by treatment-related changes in physical health

Regulatory T Cells in γ Irradiation-Induced Immune Suppression

Sublethal total body γ irradiation (TBI) of mammals causes generalized immunosuppression, in part by induction of lymphocyte apoptosis. Here, we provide evidence that a part of this immune suppression may be attributable to dysfunction of immune regulation. We investigated the effects of sublethal TBI on T cell memory responses to gain insight into the potential for loss of vaccine immunity following such exposure. We show that in mice primed to an MHC class I alloantigen, the accelerated graft rejection T memory response is specifically lost several weeks following TBI, whereas identically treated naïve mice at the same time point had completely recovered normal rejection kinetics. Depletion in vivo with anti-CD4 or anti-CD25 showed that the mechanism involved cells consistent with a regulatory T cell (T reg) phenotype. The loss of the T memory response following TBI was associated with a relative increase of CD4+CD25+ Foxp3+ expressing T regs, as compared to the CD8+ T effector cells requisite for skin graft rejection. The radiation-induced T memory suppression was shown to be antigen-specific in that a third party ipsilateral graft rejected with normal kinetics. Remarkably, following the eventual rejection of the first MHC class I disparate skin graft, the suppressive environment was maintained, with markedly prolonged survival of a second identical allograft. These findings have potential importance as regards the immunologic status of T memory responses in victims of ionizing radiation exposure and apoptosis-inducing therapies