Diversifying the Art Tech World

In this transcript of a panel discussion at the 2018 College Art Association conference, participants discuss the gender gap in the art tech world. Against a backdrop of both the current political climate and recent reporting into the gender gap in the tech industry, panelists gave short presentations of their work with commentary on their early access to technology, mentors and other support structures that helped them to create significant artwork. Questions focused on how, going forward, we can support younger, female and trans new media artists, particularly artists of color

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

ISEA2009: 15th International Symposium on electronic art – Catalogue

Catalogue of the major art exhibition that was realised as part of ISEA2009 - the 15th International Symposium on Electronic At, 23 August to 1 September 2009 Prof. Kerstin Mey initiated and competitively was awarded the hosting of ISEA2009 on the island of Ireland. In collaboration with Cherie Driver and Kathy Rae Huffman the international exhibition was developed from a juried call for exhibits

The Arts for Television

Bringing together the works of 102 artists, this exhibit promotes television as a creative medium. Works and essays are classified under the following headings: image, theatre, literature, dance, music and television. Includes a brief history of art and television as well as an index of artist's names. Bibl. 2p

Curating New Media

The proceedings of a conference at BALTIC, “Curating New Media” contains transcripts of the presentations of nine curators, artists, and artist-curators and the discussions between them about the production, distribution and exhibition of new media art. The speakers detail their experiences installing works on the Web and in galleries. Lists of participants, related URLs, and a corresponding programme of short films and videos are included. Biographical notes. 32 bibl. ref

Illuminating Video : An Essential Guide to Video Art

“Illuminating Video” is an anthology that includes 25 essays and 12 artist’s projects covering a variety of topics and perspectives on video art. It is divided into five major sections: the history of video art; its contexts; accessibility or audience reception; the syntax of video; and narrative. Hall and Fifer’s introduction describes the book as an attempt to address the complexities of the art form. Notes on contributors. Videography and video index; name and subject index. Bibliography 21 p. Circa 450 bibl. ref

Ars Electronica : Facing the Future : A Survey of Two Decades

A survey of the two decades of the Ars Electronica festival in Linz, Austria that draws on the resources of its publications and archives to represent the ongoing debate about the effects of digital media on creativity and culture. Three different sections address the history, theory and practice of electronic art. Co-founder H. Leopoldseder gives an overview of each year of the festival and its chosen theme from 1979 to1999. Biographical notes. 353 bibl. ref