Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study

International audienceBACKGROUND: Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure. OBJECTIVE: We examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy. METHODS: One thousand seventeen pregnant women were enrolled in two French municipalities between 2003 and 2005 for the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l' Enfant) cohort study. Blood lead concentrations were measured by atomic absorption spectrometry in mothers between 24 and 28 weeks of gestation. RESULTS: PIH was diagnosed in 106 subjects (10.9%). Age, parity, weight gain, alcohol, smoking habits, and calcium supplementation were comparable between hypertensive and nonhypertensive women. Lead levels were significantly higher in PIH cases (mean +/- SD, 2.2 +/- 1.4 mug/dL) than in normotensive patients (1.9 +/- 1.2 mug/dL; p = 0.02). Adjustment for potential confounder effects slightly attenuated but did not eliminate the significant association between blood lead levels and the risk of PIH (adjusted odds ratio of PIH = 3.3; 95% confidence interval, 1.1-9.7). We also observed geographic differences in lead exposure and in the incidence of PIH and found significant correlations between blood lead levels and unadjusted as well as adjusted systolic and diastolic blood pressures after 24 weeks of gestation. CONCLUSIONS: These findings confirm the relationship between blood lead levels at mid-pregnancy and blood pressure and suggest that environmental lead exposure may play an etiologic role in PIH

Spectroscopic investigation of the high-current phase of a pulsed GMAW process

International audienceWhile metal vapours have an important impact on the efficiency of the pulsed gas metal arc welding process, only a few papers are focused on this effect. In this paper, methods based on emission spectroscopy are performed to improve the understanding of the physical phenomena occurring during the high-current pulse. Boltzmann plots applied to iron lines, the Stark broadening of the 696.5 nm argon line and composition calculations assuming local thermodynamic equilibrium are used to determine characteristic parameters of the plasma. It is observed that the central part of the arc is mainly composed of iron. The percentage of iron increases quickly at the beginning of the high-current pulse, and slowly decreases, when the central part broadens. During the high-current phase the temperature profile has a minimum value of around 8000 K at the axis of the arc while the argon envelope of the central part reaches temperatures of approximately 13.000 K. High percentage of iron and high radiation of the plasma at the centre can explain the measured shape of the temperature profile

NACA Research Memorandums

Report presenting results of an investigation of the lateral stability and aileron-effectiveness characteristics of a wing with the leading-edge sweepback decreasing from 45 degrees at the root to 20 degrees at the tip. Results regarding the static lateral stability characteristics and aileron characteristics are provided

NACA Research Memorandums

Report presenting the results of an investigation in the full-scale tunnel of the static longitudinal stability and control of a convertible-type airplane as affected by articulated- and rigid-propeller operation. The investigation included force measurements for a large angle-of-attack range with the all-movable horizontal tail installed and removed

NACA Technical Notes

Report presenting the results of an investigation in the full-scale tunnel of the static longitudinal stability and control of a convertible-type airplane as affected by articulated- and rigid-propeller operation. The investigation included force measurements for a large angle-of-attack range of the model with the all-movable horizontal tail installed and removed. Results regarding the static longitudinal stability and control at normal-flight altitudes and transition range are provided

PAREX, a numeric code for plant operation aid

International audienceThe PAREX code has been widely used for process designused for the flowsheet design of the purification cycles ofthe La Hague plant build for nuclear fuel treatment. Thispaper focused on the use of the code as an aid for plantoperation through two application examples. The first oneis related to on site flow sheet available marginevaluation of the extraction zone of a first cycle flowsheet. The second example concern the plutoniumstripping operation of a plutonium cycle, where the codehas been used to explain the shift of plutonium leak in thesolvent outlet observed

Color vision loss among styrene-exposed workers neurotoxicological threshold assessment

Styrene represents nowadays one of the most used organic solvent. The current exposure limit proposed for this chemical differs significantly from country to country: the Threshold Limit Value - Time Weighted Average (TLV-TWA) proposed by the American Conference of Governmental Industrial Hygienists (ACGIH) is 50 ppm while the German, Finnish and Swedish occupational exposure limit is 20 ppm. Nevertheless, effects on the nervous system were recently reported in workers exposed at TWA styrene levels below the current TL V. Neuro-optic pathways have been sh own to be particularly vulnerable to organic solvent exposure. Analysis and measurements of visual functions can provide important information on early neurotoxic effects. Previous studies support the hypothesis that styrene exposure can induce a dose-dependent color vision loss. The aim of this study is to assess a threshold level below which no detectable effect occurs for color vision. We applied a sub-application of the change point problem in two-phase regression considering one phase as a constant line. In accordance with this model the maximum-likelihood technique was used as a method to examine the dose-effect relationship between externa I styrene exposure and chromatic discrimination. The present article presents a joint analysis of data from two previously published studies, one carried out in Canada and the other in Italy. The age and seniority of the workers from both countries were remarkably similar, as were the process type, the chemicals used and the work-tasks oi exposed subjects. The mathematical method presented here shows the existence of a statistically significant threshold. This finding shows that, in fiberglass-reinforced plastics industry, visual color impairment could be significantly detected above 4 ppm (upper limit of the confidence interval at 5% = 26 ppm). The exact clinical meaning of this effect, and also the progress of the impairment in exposed workers, is still to be assessed in further studies. The results of our study support the need of a reduction of the occupational limits for styrene in workplaces to values close to or lower than German, Finnish or Swedish exposure limits