Cognitive Speed of Processing Training Can Promote Community Mobility among Older Adults: A Brief Review

Background. Community mobility is crucial for maintaining independent functioning and quality of life for older adults. Purpose. The present paper describes the relationship of cognition, particularly speed of processing as measured by the Useful Field of View Test, to mobility as indicated by driving behaviors, life space, and falls among healthy older adults. Research examining the impact of cognitive speed of processing training (SOPT) on older adults' community mobility (i.e., driving behaviors) is also summarized. Key Issues. Even slight cognitive declines can place older adults at risk for mobility limitations. However, cognitive interventions like SOPT can mitigate declines in driving mobility. Implications. The potential of SOPT to sustain community mobility among older adults is discussed

A comparison of single-cycle versus multiple-cycle proof testing strategies

An evaluation of single-cycle and multiple-cycle proof testing (MCPT) strategies for SSME components is described. Data for initial sizes and shapes of actual SSME hardware defects are analyzed statistically. Closed-form estimates of the J-integral for surface flaws are derived with a modified reference stress method. The results of load- and displacement-controlled stable crack growth tests on thin IN-718 plates with deep surface flaws are summarized. A J-resistance curve for the surface-cracked configuration is developed and compared with data from thick compact tension specimens. The potential for further crack growth during large unload/reload cycles is discussed, highlighting conflicting data in the literature. A simple model for ductile crack growth during MCPT based on the J-resistance curve is used to study the potential effects of key variables. The projected changes in the crack size distribution during MCPT depend on the interactions between several key parameters, including the number of proof cycles, the nature of the resistance curve, the initial crack size distribution, the component boundary conditions (load vs. displacement control), and the magnitude of the applied load or displacement. The relative advantages of single-cycle and multiple-cycle proof testing appear to be specific, therefore, to individual component geometry, material, and loading

Relative cost-effectiveness of using a liquid human milk fortifier in preterm infants in the US

Objective: To estimate the cost-effectiveness of using a liquid human milk fortifier (LHMF) compared to a powdered human milk fortifier (PHMF) in preterm infants in the US from the perspective of third-party payers and parents. Methods: This was a decision modelling study using patient data obtained from a random- ized controlled trial comparing a LHMF with a PHMF in preterm infants, supplemented with additional data obtained by performing a chart review among 79% of the trial patients. The model estimated the cost-effectiveness of LHMF versus PHMF in US$at 2014/2015 prices. Results: More infants in the LHMF group were discharged home (92$10,497 per infant less in the LHMF group than the PHMF group ($240,928 versus$251,425). Conclusion: Using LHMF instead of PHMF in preterm infants enabled resources to be freed-up for alternative use within the system. There is no health economic reason why LHMF should not be used in preference to PHMF in the NICU

The National Childrens Study: An Introduction and Historical Overview

The National Children’s Study (NCS) was an ambitious attempt to map children’s health and development in a large representative group of children in the United States. In this introduction, we briefly review the background of the NCS and the history of the multiple strategies that were tested to recruit women and children. Subsequent articles then detail the protocols and outcomes of 4 of the recruitment strategies. It is hoped that lessons learned from these attempts to define a study protocol that could achieve the initial aims of the NCS will inform future efforts to conceptualize and execute strategies to provide generalizable insights on the longitudinal health of our nation’s children

Lake Breezes in Southern Ontario and Their Relation to Tornado Climatology

Geostationary Operational Environmental Satellite (GOES) imagery is used to demonstrate the development of lake-breeze boundaries in southern Ontario under different synoptic conditions. The orientation of the gradient wind with respect to the shorelines is important in determining the location of such lines. When moderate winds (5–10 m s21) are parallel to straight sections of coastlines, cloud lines can extend well inland. In the region between Lakes Huron and Erie lake-breeze lines merge frequently, sometimes resulting in long-lasting stationary storms and attendant heavy rain and flooding. The influence of the lakes is apparent in the tornado climatology for the region: tornadoes appear to be suppressed in regions visited by lake-modified air and enhanced in regions favored by lake-breeze convergence lines. The cloud patterns in the case of a cold front interacting with merging lake-breeze boundaries are shown to be similar to those on a major tornado outbreak day. Two of the cases discussed are used as conceptual models to explain many of the features in the patterns of tornado touchdown locations. In general, it appears that the lakes suppress tornadoes in southern Ontario, compared with neighboring states and in particular in areas where southwest winds are onshore, but enhance tornado likelihood locally in areas of frequent lake-breeze activity. 1

A Comparative Study of Machine Learning Regression Methods on LiDAR Data: A Case Study

Light Detection and Ranging (LiDAR) is a remote sensor able to extract vertical information from sensed objects. LiDAR-derived information is nowadays used to develop environmental models for describing fire behaviour or quantifying biomass stocks in forest areas. A multiple linear regression (MLR) with previous stepwise feature selection is the most common method in the literature to develop LiDAR-derived models. MLR defines the relation between the set of field measurements and the statistics extracted from a LiDAR flight. Machine learning has recently been paid an increasing attention to improve classic MLR results. Unfortunately, few studies have been proposed to compare the quality of the multiple machine learning approaches. This paper presents a comparison between the classic MLR-based methodology and common regression techniques in machine learning (neural networks, regression trees, support vector machines, nearest neighbour, and ensembles such as random forests). The selected techniques are applied to real LiDAR data from two areas in the province of Lugo (Galizia, Spain). The results show that support vector regression statistically outperforms the rest of techniques when feature selection is applied. However, its performance cannot be said statistically different from that of Random Forests when previous feature selection is skipped

The remote monad design pattern

Remote Procedure Calls are expensive. This paper demonstrates how to reduce the cost of calling remote procedures from Haskell by using the remote monad design pattern, which amortizes the cost of remote calls. This gives the Haskell community access to remote capabilities that are not directly supported, at a surprisingly inexpensive cost. We explore the remote monad design pattern through six models of remote execution patterns, using a simulated Internet of Things toaster as a running example. We consider the expressiveness and optimizations enabled by each remote execution model, and assess the feasibility of our approach. We then present a full-scale case study: a Haskell library that provides a Foreign Function Interface to the JavaScript Canvas API. Finally, we discuss existing instances of the remote monad design pattern found in Haskell libraries

Clinical course, costs and predictive factors for response to treatment in carpal tunnel syndrome: The PALMS study protocol

Background Carpal tunnel syndrome (CTS) is the most common neuropathy of the upper limb and a significant contributor to hand functional impairment and disability. Effective treatment options include conservative and surgical interventions, however it is not possible at present to predict the outcome of treatment. The primary aim of this study is to identify which baseline clinical factors predict a good outcome from conservative treatment (by injection) or surgery in patients diagnosed with carpal tunnel syndrome. Secondary aims are to describe the clinical course and progression of CTS, and to describe and predict the UK cost of CTS to the individual, National Health Service (NHS) and society over a two year period. Methods/Design In this prospective observational cohort study patients presenting with clinical signs and symptoms typical of CTS and in whom the diagnosis is confirmed by nerve conduction studies are invited to participate. Data on putative predictive factors are collected at baseline and follow-up through patient questionnaires and include standardised measures of symptom severity, hand function, psychological and physical health, comorbidity and quality of life. Resource use and cost over the 2 year period such as prescribed medications, NHS and private healthcare contacts are also collected through patient self-report at 6, 12, 18 and 24 months. The primary outcome used to classify treatment success or failures will be a 5-point global assessment of change. Secondary outcomes include changes in clinical symptoms, functioning, psychological health, quality of life and resource use. A multivariable model of factors which predict outcome and cost will be developed. Discussion This prospective cohort study will provide important data on the clinical course and UK costs of CTS over a two-year period and begin to identify predictive factors for treatment success from conservative and surgical interventions

Does inter-vertebral range of motion increase after spinal manipulation? A prospective cohort study.

Background: Spinal manipulation for nonspecific neck pain is thought to work in part by improving inter-vertebral range of motion (IV-RoM), but it is difficult to measure this or determine whether it is related to clinical outcomes. Objectives: This study undertook to determine whether cervical spine flexion and extension IV-RoM increases after a course of spinal manipulation, to explore relationships between any IV-RoM increases and clinical outcomes and to compare palpation with objective measurement in the detection of hypo-mobile segments. Method: Thirty patients with nonspecific neck pain and 30 healthy controls matched for age and gender received quantitative fluoroscopy (QF) screenings to measure flexion and extension IV-RoM (C1-C6) at baseline and 4-week follow-up between September 2012-13. Patients received up to 12 neck manipulations and completed NRS, NDI and Euroqol 5D-5L at baseline, plus PGIC and satisfaction questionnaires at follow-up. IV-RoM accuracy, repeatability and hypo-mobility cut-offs were determined. Minimal detectable changes (MDC) over 4 weeks were calculated from controls. Patients and control IV-RoMs were compared at baseline as well as changes in patients over 4 weeks. Correlations between outcomes and the number of manipulations received and the agreement (Kappa) between palpated and QF-detected of hypo-mobile segments were calculated. Results: QF had high accuracy (worst RMS error 0.5o) and repeatability (highest SEM 1.1o, lowest ICC 0.90) for IV-RoM measurement. Hypo-mobility cut offs ranged from 0.8o to 3.5o. No outcome was significantly correlated with increased IV-RoM above MDC and there was no significant difference between the number of hypo-mobile segments in patients and controls at baseline or significant increases in IV-RoMs in patients. However, there was a modest and significant correlation between the number of manipulations received and the number of levels and directions whose IV-RoM increased beyond MDC (Rho=0.39, p=0.043). There was also no agreement between palpation and QF in identifying hypo-mobile segments (Kappa 0.04-0.06). Conclusions: This study found no differences in cervical sagittal IV-RoM between patients with non-specific neck pain and matched controls. There was a modest dose-response relationship between the number of manipulations given and number of levels increasing IV-RoM - providing evidence that neck manipulation has a mechanical effect at segmental levels. However, patient-reported outcomes were not related to this

The roles of nearest neighbor methods in imputing missing data in forest inventory and monitoring databases

Almost universally, forest inventory and monitoring databases are incomplete, ranging from missing data for only a few records and a few variables, common for small land areas, to missing data for many observations and many variables, common for large land areas. For a wide variety of applications, nearest neighbor (NN) imputation methods have been developed to fill in observations of variables that are missing on some records (Y-variables), using related variables that are available for all records (X-variables). This review attempts to summarize the advantages and weaknesses of NN imputation methods and to give an overview of the NN approaches that have most commonly been used. It also discusses some of the challenges of NN imputation methods. The inclusion of NN imputation methods into standard software packages and the use of consistent notation may improve further development of NN imputation methods. Using X-variables from different data sources provides promising results, but raises the issue of spatial and temporal registration errors. Quantitative measures of the contribution of individual X-variables to the accuracy of imputing the Y-variables are needed. In addition, further research is warranted to verify statistical properties, modify methods to improve statistical properties, and provide variance estimators.Keywords: registration error, forest measurements, consistent notation, input data for forest planning, nearest neighbor imputation, sources of X-variablesKeywords: registration error, forest measurements, consistent notation, input data for forest planning, nearest neighbor imputation, sources of X-variable