Pengaruh Pelayanan Jasa Terhadap Tingkat Kepuasan Nasabah Di BMT Amanah Ummah Sukoharjo

Tujuan penelitian adalah Untuk menjelaskan pengaruh tangibles, reability, responsiveness, assurance, emphaty secara simultan berpengaruh terhadap kepuasan Nasabah dan Untuk menjelasakan pengaruh tangibles, reability, responsiveness, assurance, emphaty secara individual berpengaruh terhadap kepuasan Nasabah. Penelitian ini di lakukan pada sebuah Koperasi Jasa Keuangan Syariah (KJKS) yaitu di BMT AMANAH UMMAH DI SUKOHARJO dengan menggunakan responden berjumlah 100 responden sebagai sampel untuk di jadikan bahan penelitian kuantitatif, dan untuk menganalisis data kuantitatif menggunakan alat Regresi Linier Berganda. Hasil penelitian menunjukkan bahwa hasil dari Uji T di peroleh hanya variabel Assurance yang menunjukkan pengaruh positif terhadap kepuasan nasabah, variabel Tangibles, Responsivenees, Reliabel, Emphaty tidak menunjukkan pengaruh yang positif terhadapa tingkat kepuasan nasabah, hanya Variabel Tangibles yang paling berpengaruh positif terhadap tingkat kepuasan nasabah. Berdasarkan hasil Uji F maka secara simultan variabel Tangibles, Responsivenees, Reliability, Assurance, Emphaty tidak berpengaruh positif terhadap kepuasan nasabah

Advanced power routing framework for optimal economic operation and control of solar photovoltaic-based islanded microgrid

© 2019 Institution of Engineering and Technology. All rights reserved. Energy sharing through a microgrid (MG) is essential for islanded communities to maximise the use of distributed energy resources (DERs) and battery energy storage systems (BESSs). Proper energy management and control strategies of such MGs can offer revenue to prosumers (active consumers with DERs) by routing excess energy to their neighbours and maintaining grid constraints at the same time. This paper proposes an advanced power-routing framework for a solarphotovoltaic (PV)-based islanded MG with a central storage system (CSS). An optimisation-based economic operation for the MG is developed that determines the power routing and energy sharing in the MG in the day-ahead stage. A modified droop controller-based real-time control strategy has been established that maintains the voltage constraints of the MG. The proposed power-routing framework is verified via a case study for a typical islanded MG. The outcome of the optimal economic operation and a controller verification of the proposed framework are presented to demonstrate the effectiveness of the proposed powerrouting framework. Results reveal that the proposed framework performs a stable control operation and provides a profit of 57 AU$/day at optimal conditions

Conservation tillage and residue management improve soil health and crop productivity—Evidence from a rice-maize cropping system in Bangladesh.

The rice-maize (R-M) system is rapidly expanding in Bangladesh due to its greater suitability for diverse soil types and environments. The present conventional method of cultivating puddled transplanted rice and maize is input-intensive, decreases soil health through intense ploughing, and ultimately reduces farm profitability. There is a need to investigate alternatives. Accordingly, we conducted a replicated 2-year (2020–2021) field study to investigate the effects of conservation agriculture (CA) based tillage and crop establishment (TCE) techniques and residue management practices on the physical, chemical, and biological properties of soil along with crop productivity and the profitability of rice-maize systems in the sandy loam soil of Northwest Bangladesh. Two TCE techniques Puddled transplanted rice (PTR) followed by Conventional tillage maize (CTM) and strip tillage direct-seeded rice (STDSR) followed by strip-tilled maize (STM) were assigned to the main plots and different percentages of crop residue retention (0, 25, and 50% by height) were allocated to the subplots. Results showed that a reduction in bulk density (BD), soil penetration resistance (SPR), and increased soil porosity were associated with STDSR/STM-based scenarios (strip tillage coupled with 25 and 50% residue retention). The soil organic carbon (SOC) fractions, such as dissolved organic C (DOC), light and heavy particulate organic matter C (POM-C), MAOM, and microbial biomass C (MBC) levels in the 0–10 cm layer under ST based treatments were 95, 8, 6, 2 and 45% greater, respectively, compared to CT with no residue treatment. When compared to the CT treatment, the DOC, light POM-C, heavy POM-C, and MAOM in the 10–20 cm layer with ST treatment were 8, 34, 25, 4 and 37% higher, respectively. Residue retention in ST increased average rice, maize, and system yields by 9.2, 14.0, and 14.12%, respectively, when compared to CT. The system gross margin and benefit-cost ratio (BCR) were $1,515 ha−1 and 1.90 under conventional tillage to$1,696 ha−1 and 2.15 under strip-tillage practices. Thus, our study suggests that CA could be an appropriate practice for sustaining soil fertility and crop yield under R-M systems in light-textured soils or other similar soils in Bangladesh

Genetic predictors of cardiovascular morbidity in Bardet-Biedl syndrome

Bardet-Biedl syndrome is a rare ciliopathy characterized by retinal dystrophy, obesity, intellectual disability, polydactyly, hypogonadism and renal impairment. Patients are at high risk of cardiovascular disease. Mutations in BBS1 and BBS10 account for more than half of those with molecular confirmation of the diagnosis. To elucidate genotype-phenotype correlations with respect to cardiovascular risk indicators 50 patients with mutations in BBS1 were compared with 19 patients harbouring BBS10 mutations. All patients had truncating, missense or compound missense/truncating mutations. The effect of genotype and mutation type was analysed. C-reactive protein was higher in those with mutations in BBS10 and homozygous truncating mutations (p = 0.013 and p = 0.002, respectively). Patients with mutations in BBS10 had higher levels of C peptide than those with mutations in BBS1 (p = 0.043). Triglyceride levels were significantly elevated in patients with homozygous truncating mutations (p = 0.048). Gamma glutamyl transferase was higher in patients with homozygous truncating mutations (p = 0.007) and heterozygous missense and truncating mutations (p = 0.002) than those with homozygous missense mutations. The results are compared with clinical cardiovascular risk factors. Patients with missense mutations in BBS1 have lower biochemical cardiovascular disease markers compared with patients with BBS10 and other BBS1 mutations. This could contribute to stratification of the clinical service

Mechanical properties of cotton fabric reinforced geopolymer composites at 200-1000 °C

Geopolymer composites containing woven cotton fabric (0–8.3 wt%) were fabricated using the hand lay-up technique, and were exposed to elevated temperatures of 200 °C, 400 °C, 600 °C, 800 °C and 1000 °C. With an increase in temperature, the geopolymer composites exhibited a reduction in compressive strength, flexural strength and fracture toughness. When heated above 600 °C, the composites exhibited a significant reduction in mechanical properties. They also exhibited brittle behavior due to severe degradation of cotton fibres and the creation of additional porosity in the composites. Microstructural images verified the existence of voids and small channels in the composites due to fibre degradation

Genetic Polymorphisms in the Hypothalamic Pathway in Relation to Subsequent Weight Change – The DiOGenes Study

BACKGROUND: Single nucleotide polymorphisms (SNPs) in genes encoding the components involved in the hypothalamic pathway may influence weight gain and dietary factors may modify their effects. AIM: We conducted a case-cohort study to investigate the associations of SNPs in candidate genes with weight change during an average of 6.8 years of follow-up and to examine the potential effect modification by glycemic index (GI) and protein intake. METHODS AND FINDINGS: Participants, aged 20-60 years at baseline, came from five European countries. Cases ('weight gainers') were selected from the total eligible cohort (n = 50,293) as those with the greatest unexplained annual weight gain (n = 5,584). A random subcohort (n = 6,566) was drawn with the intention to obtain an equal number of cases and noncases (n = 5,507). We genotyped 134 SNPs that captured all common genetic variation across the 15 candidate genes; 123 met the quality control criteria. Each SNP was tested for association with the risk of being a 'weight gainer' (logistic regression models) in the case-noncase data and with weight gain (linear regression models) in the random subcohort data. After accounting for multiple testing, none of the SNPs was significantly associated with weight change. Furthermore, we observed no significant effect modification by dietary factors, except for SNP rs7180849 in the neuromedin β gene (NMB). Carriers of the minor allele had a more pronounced weight gain at a higher GI (P = 2 x 10⁻⁷). CONCLUSIONS: We found no evidence of association between SNPs in the studied hypothalamic genes with weight change. The interaction between GI and NMB SNP rs7180849 needs further confirmation

Vaccination against GIP for the Treatment of Obesity

BACKGROUND: According to the WHO, more than 1 billion people worldwide are overweight and at risk of developing chronic illnesses, including cardiovascular disease, type 2 diabetes, hypertension and stroke. Current therapies show limited efficacy and are often associated with unpleasant side-effect profiles, hence there is a medical need for new therapeutic interventions in the field of obesity. Gastric inhibitory peptide (GIP, also known as glucose-dependent insulinotropic polypeptide) has recently been postulated to link over-nutrition with obesity. In fact GIP receptor-deficient mice (GIPR(-/-)) were shown to be completely protected from diet-induced obesity. Thus, disrupting GIP signaling represents a promising novel therapeutic strategy for the treatment of obesity. METHODOLOGY/PRINCIPAL FINDINGS: In order to block GIP signaling we chose an active vaccination approach using GIP peptides covalently attached to virus-like particles (VLP-GIP). Vaccination of mice with VLP-GIP induced high titers of specific antibodies and efficiently reduced body weight gain in animals fed a high fat diet. The reduction in body weight gain could be attributed to reduced accumulation of fat. Moreover, increased weight loss was observed in obese mice vaccinated with VLP-GIP. Importantly, despite the incretin action of GIP, VLP-GIP-treated mice did not show signs of glucose intolerance. CONCLUSIONS/SIGNIFICANCE: This study shows that vaccination against GIP was safe and effective. Thus active vaccination may represent a novel, long-lasting treatment for obesity. However further preclinical safety/toxicology studies will be required before the therapeutic concept can be addressed in humans

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1

Telomere integrity (including telomere length and capping) is critical in overall genomic stability. Telomere repeat binding factors and their associated proteins play vital roles in telomere length regulation and end protection. In this study, we explore the protein network surrounding telomere repeat binding factors, TRF1, TRF2, and POT1 using dual-tag affinity purification in combination with multidimensional protein identification technology liquid chromatography - tandem mass spectrometry (MudPIT LC-MS/MS). After control subtraction and data filtering, we found that TRF2 and POT1 co-purified all six members of the telomere protein complex, while TRF1 identified five of six components at frequencies that lend evidence towards the currently accepted telomere architecture. Many of the known TRF1 or TRF2 interacting proteins were also identified. Moreover, putative associating partners identified for each of the three core components fell into functional categories such as DNA damage repair, ubiquitination, chromosome cohesion, chromatin modification/remodeling, DNA replication, cell cycle and transcription regulation, nucleotide metabolism, RNA processing, and nuclear transport. These putative protein-protein associations may participate in different biological processes at telomeres or, intriguingly, outside telomeres

Development of Gene Expression Markers of Acute Heat-Light Stress in Reef-Building Corals of the Genus Porites

Coral reefs are declining worldwide due to increased incidence of climate-induced coral bleaching, which will have widespread biodiversity and economic impacts. A simple method to measure the sub-bleaching level of heat-light stress experienced by corals would greatly inform reef management practices by making it possible to assess the distribution of bleaching risks among individual reef sites. Gene expression analysis based on quantitative PCR (qPCR) can be used as a diagnostic tool to determine coral condition in situ. We evaluated the expression of 13 candidate genes during heat-light stress in a common Caribbean coral Porites astreoides, and observed strong and consistent changes in gene expression in two independent experiments. Furthermore, we found that the apparent return to baseline expression levels during a recovery phase was rapid, despite visible signs of colony bleaching. We show that the response to acute heat-light stress in P. astreoides can be monitored by measuring the difference in expression of only two genes: Hsp16 and actin. We demonstrate that this assay discriminates between corals sampled from two field sites experiencing different temperatures. We also show that the assay is applicable to an Indo-Pacific congener, P. lobata, and therefore could potentially be used to diagnose acute heat-light stress on coral reefs worldwide