212 research outputs found
Unterschiedliche Entwurmung von laktierenden Milchziegen: Einfluss auf Milchleistung und Parasiteneierzahl im Kot
The effects of different deworming methods of grazing and lactating goats on fecal egg count (fec) and milk yield were examined. Fec was determined by a modified McMaster method with a sensitivity of 40 eggs per gram feces. At day 66 of the grazing period, the animals were allocated to two groups depending on the milk yield (low = MN, high = MH). Half of each group was dewormed. In the first year of the trial
animals with low as well as high fec were dewormed. The averages of fec in the groups (C-0 = no deworming, C-M = deworming) were not different at the time of
deworming. In the second year of the trial only animals with high fec were dewormed. The averages of the EPG in the groups (C-0 = no deworming, C-H = deworming) were different at the time of deworming. Examination weeks were combined to three periods (week1-9 (before deworming), week10-15 (after deworming), week 16-22 (fec after deworming)). Deworming had a significant influence in fec in week10-15, but not
in week 16-22. Deworming resulted in lower fec as a short term effect and elevated fec as a long term effect in both deworming regimes. One possible reason therefor could be a lack of immunity due to deworming
Die Todtenfackel, oder: die Höhle der Siebenschläfer : ein Schauspiel mit Gesang in vier Aufzügen ; zur freyen Einnahme für das Handlungs-Verpflegungs-Institut
Doppler gradient estimations across tunnel obstructions: An in vitro study including flow visualization
Subgroup-specific gene expression profiles and mixed epistasis in chronic lymphocytic leukemia
Understanding the molecular and phenotypic heterogeneity of cancer is a prerequisite for effective treatment. For chronic lymphocytic leukemia (CLL), recurrent genetic driver events have been extensively cataloged, but this does not suffice to explain the disease's diverse course. Here, we performed RNA sequencing on 184 CLL patient samples. Unsupervised analysis revealed two major, orthogonal axes of gene expression variation: the first one represented the mutational status of the immunoglobulin heavy variable (IGHV) genes, and concomitantly, the three-group stratification of CLL by global DNA methylation. The second axis aligned with trisomy 12 status and affected chemokine, MAPK and mTOR signaling. We discovered non-additive effects (epistasis) of IGHV mutation status and trisomy 12 on multiple phenotypes, including the expression of 893 genes. Multiple types of epistasis were observed, including synergy, buffering, suppression and inversion, suggesting that molecular understanding of disease heterogeneity requires studying such genetic events not only individually but in combination. We detected strong differentially expressed gene signatures associated with major gene mutations and copy number aberrations including SF3B1, BRAF and TP53, as well as del(17)(p13), del(13)(q14) and del(11)(q22.3) beyond dosage effect. Our study reveals previously underappreciated gene expression signatures for the major molecular subtypes in CLL and the presence of epistasis between them
Estimating the Minimal Important Difference for the Western Ontario Rotator Cuff Index (WORC) in adults with shoulder pain associated with partial-thickness rotator cuff tears
The rovibrational spectrum of BeH, MgH and CaH at high temperatures in the state: a theoretical study
Accurate line lists for three molecules, BeH, MgH and CaH, in their ground
electronic states are presented. These line lists are suitable for temperatures
relevant to exoplanetary atmospheres and cool stars (up to 2000K). A
combination of empirical and \textit{ab initio} methods is used. The
rovibrational energy levels of BeH, MgH and CaH are computed using the programs
Level and DPotFit in conjunction with `spectroscopic' potential energy curves
(PECs). The PEC of BeH is taken from the literature, while the PECs of CaH and
MgH are generated by fitting to the experimental transition energy levels. Both
spin-rotation interactions (except for BeH, for which it is negligible) and
non-adiabatic corrections are explicitly taken into account. Accurate line
intensities are generated using newly computed \textit{ab initio} dipole moment
curves for each molecule using high levels of theory. Full line lists of
rotation-vibration transitions for BeH, MgH, MgH, MgH
and CaH are made available in an electronic form as supplementary data
to this article and at \url{www.exomol.com}.Comment: MNRAS (in press
Geometry of River Networks I: Scaling, Fluctuations, and Deviations
This article is the first in a series of three papers investigating the
detailed geometry of river networks. Large-scale river networks mark an
important class of two-dimensional branching networks, being not only of
intrinsic interest but also a pervasive natural phenomenon. In the description
of river network structure, scaling laws are uniformly observed. Reported
values of scaling exponents vary suggesting that no unique set of scaling
exponents exists. To improve this current understanding of scaling in river
networks and to provide a fuller description of branching network structure, we
report here a theoretical and empirical study of fluctuations about and
deviations from scaling. We examine data for continent-scale river networks
such as the Mississippi and the Amazon and draw inspiration from a simple model
of directed, random networks. We center our investigations on the scaling of
the length of sub-basin's dominant stream with its area, a characterization of
basin shape known as Hack's law. We generalize this relationship to a joint
probability density and show that fluctuations about scaling are substantial.
We find strong deviations from scaling at small scales which can be explained
by the existence of linear network structure. At intermediate scales, we find
slow drifts in exponent values indicating that scaling is only approximately
obeyed and that universality remains indeterminate. At large scales, we observe
a breakdown in scaling due to decreasing sample space and correlations with
overall basin shape. The extent of approximate scaling is significantly
restricted by these deviations and will not be improved by increases in network
resolution.Comment: 16 pages, 13 figures, Revtex4, submitted to PR
Nanosilver/DCOIT-containing surface coating effectively and constantly reduces microbial load in emergency room surfaces
Background
Colonization of near-patient surfaces in hospitals plays an important role as a source of healthcare-associated infections. Routine disinfection methods only result in short-term elimination of pathogens.
Aim
To investigate the efficiency of a newly developed antimicrobial coating containing nanosilver in long-term reduction of bacterial burden in hospital surfaces to close the gap between routine disinfection cycles.
Methods
In this prospective, double-blinded trial, frequently touched surfaces of a routinely used treatment room in an emergency unit of a level-I hospital were treated with a surface coating (nanosilver/DCOIT-coated surface, NCS) containing nanosilver particles and another organic biocidal agent (4,5-dichloro-2-octyl-4-isothiazolin-3-one, DCOIT), whereas surfaces of another room were treated with a coating missing both the nanosilver- and DCOIT-containing ingredient and served as control. Bacterial contamination of the surfaces was examined using contact plates and liquid-based swabs daily for a total trial duration of 90 days. After incubation, total microbial counts and species were assessed.
Findings
In a total of 2880 antimicrobial samples, a significant reduction of the overall bacterial load was observed in the NCS room (median: 0.31 cfu/cm2; interquartile range: 0.00–1.13) compared with the control coated surfaces (0.69 cfu/cm2; 0.06–2.00; P 5 cfu/cm2) by 60% (odds ratio 0.38, P < 0.001). No significant difference in species distribution was detected between NCS and control group.
Conclusion
Nanosilver-/DCOIT-containing surface coating has shown efficiency for sustainable reduction of bacterial load of frequently touched surfaces in a clinical setting
Materials Cloud, a platform for open computational science
Materials Cloud is a platform designed to enable open and seamless sharing of
resources for computational science, driven by applications in materials
modelling. It hosts 1) archival and dissemination services for raw and curated
data, together with their provenance graph, 2) modelling services and virtual
machines, 3) tools for data analytics, and pre-/post-processing, and 4)
educational materials. Data is citable and archived persistently, providing a
comprehensive embodiment of the FAIR principles that extends to computational
workflows. Materials Cloud leverages the AiiDA framework to record the
provenance of entire simulation pipelines (calculations performed, codes used,
data generated) in the form of graphs that allow to retrace and reproduce any
computed result. When an AiiDA database is shared on Materials Cloud, peers can
browse the interconnected record of simulations, download individual files or
the full database, and start their research from the results of the original
authors. The infrastructure is agnostic to the specific simulation codes used
and can support diverse applications in computational science that transcend
its initial materials domain.Comment: 19 pages, 8 figure
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