1,063 research outputs found
A young man with position-dependent erectile dysfunction: diagnostic work-up and interventional therapy of an arteriovenous malformation
Brief for Multi-Chem Chemical Company, Intervenor: Second Annual Pace National Environmental Moot Court Competition
Glycosylation Patterns of Proteins Studied by Liquid Chromatography-Mass Spectrometry and Bioinformatic Tools
Due to their extensive structural heterogeneity, the elucidation of glycosylation patterns in glycoproteins such as the subunits of chorionic gonadotropin (CG), CG-alpha and CG-beta remains one of the most challenging problems in the proteomic analysis of posttranslational modifications. In consequence, glycosylation is usually studied after decomposition of the intact proteins to the proteolytic peptide level. However, by this approach all information about the combination of the different glycopeptides in the intact protein is lost. In this study we have, therefore, attempted to combine the results of glycan identification after tryptic digestion with molecular mass measurements on the intact glycoproteins. Despite the extremely high number of possible combinations of the glycans identified in the tryptic peptides by high-performance liquid chromatography-mass spectrometry (> 1000 for CG-alpha and > 10.000 for CG-beta), the mass spectra of intact CG-alpha and CG-beta revealed only a limited number of glycoforms present in CG preparations from pools of pregnancy urines. Peak annotations for CG-alpha were performed with the help of an algorithm that generates a database containing all possible modifications of the proteins (inclusive possible artificial modifications such as oxidation or truncation) and subsequent searches for combinations fitting the mass difference between the polypeptide backbone and the measured molecular masses. Fourteen different glycoforms of CG-alpha, including methionine-oxidized and N-terminally truncated forms, were readily identified. For CG-beta, however, the relatively high mass accuracy of ± 2 Da was still insufficient to unambiguously assign the possible combinations of posttranslational modifications. Finally, the mass spectrometric fingerprints of the intact molecules were shown to be very useful for the characterization of glycosylation patterns in different CG preparations
Magnetic impurity in a one-dimensional few-fermion system
We present a numerical analysis of spin- fermions in a
one-dimensional harmonic potential in the presence of a magnetic point-like
impurity at the center of the trap. The model represents a few-body analogue of
a magnetic impurity in the vicinity of an -wave superconductor. Already for
a few particles we find a ground-state level crossing between sectors with
different fermion parities. We interpret this crossing as a few-body precursor
of a quantum phase transition, which occurs when the impurity `breaks' a Cooper
pair. This picture is further corroborated by analyzing density-density
correlations in momentum space. Finally, we discuss how the system may be
realized with existing cold-atoms platforms.Comment: SciPost Submissio
The GRAVITY metrology system: modeling a metrology in optical fibers
GRAVITY is the second generation VLT Interferometer (VLTI) instrument for
high-precision narrow-angle astrometry and phase-referenced interferometric
imaging. The laser metrology system of GRAVITY is at the heart of its
astrometric mode, which must measure the distance of 2 stars with a precision
of 10 micro-arcseconds. This means the metrology has to measure the optical
path difference between the two beam combiners of GRAVITY to a level of 5 nm.
The metrology design presents some non-common paths that have consequently to
be stable at a level of 1 nm. Otherwise they would impact the performance of
GRAVITY. The various tests we made in the past on the prototype give us hints
on the components responsible for this error, and on their respective
contribution to the total error. It is however difficult to assess their exact
origin from only OPD measurements, and therefore, to propose a solution to this
problem. In this paper, we present the results of a semi-empirical modeling of
the fibered metrology system, relying on theoretical basis, as well as on
characterisations of key components. The modeling of the metrology system
regarding various effects, e.g., temperature, waveguide heating or mechanical
stress, will help us to understand how the metrology behave. The goals of this
modeling are to 1) model the test set-ups and reproduce the measurements (as a
validation of the modeling), 2) determine the origin of the non-common path
errors, and 3) propose modifications to the current metrology design to reach
the required 1nm stability.Comment: 20 pages, 19 figures. Proceeding of SPIE 9146 "Optical and Infrared
Interferometry IV
GRAVITY: the Calibration Unit
We present in this paper the design and characterisation of a new sub-system
of the VLTI 2nd generation instrument GRAVITY: the Calibration Unit. The
Calibration Unit provides all functions to test and calibrate the beam combiner
instrument: it creates two artificial stars on four beams, and dispose of four
delay lines with an internal metrology. It also includes artificial stars for
the tip-tilt and pupil guiding systems, as well as four metrology pick-up
diodes, for tests and calibration of the corresponding sub-systems. The
calibration unit also hosts the reference targets to align GRAVITY to the VLTI,
and the safety shutters to avoid the metrology light to propagate in the
VLTI-lab. We present the results of the characterisation and validtion of these
differrent sub-units.Comment: 12 pages, 11 figures. Proceeding of SPIE 9146 "Optical and Infrared
Interferometry IV
Asteroseismology of the Hyades red giant and planet host epsilon Tauri
Asteroseismic analysis of solar-like stars allows us to determine physical
parameters such as stellar mass, with a higher precision compared to most other
methods. Even in a well-studied cluster such as the Hyades, the masses of the
red giant stars are not well known, and previous mass estimates are based on
model calculations (isochrones). The four known red giants in the Hyades are
assumed to be clump (core-helium-burning) stars based on their positions in
colour-magnitude diagrams, however asteroseismology offers an opportunity to
test this assumption. Using asteroseismic techniques combined with other
methods, we aim to derive physical parameters and the evolutionary stage for
the planet hosting star epsilon Tau, which is one of the four red giants
located in the Hyades. We analysed time-series data from both ground and space
to perform the asteroseismic analysis. By combining high signal-to-noise (S/N)
radial-velocity data from the ground-based SONG network with continuous
space-based data from the revised Kepler mission K2, we derive and characterize
27 individual oscillation modes for epsilon Tau, along with global oscillation
parameters such as the large frequency separation and the ratio between the
amplitude of the oscillations measured in radial velocity and intensity as a
function of frequency. The latter has been measured previously for only two
stars, the Sun and Procyon. Combining the seismic analysis with interferometric
and spectroscopic measurements, we derive physical parameters for epsilon Tau,
and discuss its evolutionary status.Comment: 13 pages, 13 figures, 4 tables, accepted for publication in Astronomy
& Astrophysic
Interplay of superexchange and orbital degeneracy in Cr-doped LaMnO3
We report on structural, magnetic and Electron Spin Resonance (ESR)
investigations in the manganite system LaMn_{1-x}Cr_{x}O_{3} (x<=0.5). Upon
Cr-doping we observe a reduction of the Jahn-Teller distortion yielding less
distorted orthorhombic structures. A transition from the Jahn-Teller distorted
O' to the pseudocubic O phase occurs between 0.3<x<0.4. A clear connection
between this transition and the doping dependence of the magnetic and ESR
properties has been observed. The effective moments determined by ESR seem
reduced with respect to the spin-only value of both Mn^{3+} and Cr^{3+} ions
- …