Coverage Optimization Strategy for WSN based on Energy-aware

In order to optimize the wireless sensor network coverage, this paper designs a coverage optimization strategy for wireless sensor network (EACS) based on energy-aware. Under the assumption that the geographic positions of sensor nodes are available, the proposed strategy consists of energy-aware and network coverage adjustment. It is restricted to conditions such as path loss, residual capacity and monitored area and according to awareness ability of sensors, it would adjust the monitored area, repair network hole and kick out the redundant coverage. The purpose is to balance the energy distribution of working nodes, reduce the number of “dead” nodes and balance network energy consumption. As a result, the network lifetime is expanded. Simulation results show that: EACS effectively reduces the number of working nodes, improves network coverage, lowers network energy consumption while ensuring the wireless sensor network coverage and connectivity, so as to balance network energy consumption

Modified (A)dS Schwarzschild black holes in Rainbow spacetime

A modified (Anti-)de Sitter Schwarzschild black hole solution is presented in the framework of rainbow gravity with a cosmological constant. Its thermodynamical properties are investigated. In general the temperature of modified black holes is dependent on the energy of probes which take the measurement. However, a notion of intrinsic temperature can be introduced by identifying these probes with radiation particles emitted from black holes. It is interesting to find that the Hawking temperature of this sort of black holes can be reproduced by employing the extended uncertainty principle and modified dispersion relations to the ordinary (A)dS Schwarzschild black holes.Comment: 11 pages. The version to appear in CQ

Modified dispersion relations and (A)dS Schwarzschild Black holes

In this paper we investigate the impact of modified dispersion relations (MDR) on (Anti)de Sitter-Schwarzschild black holes. In this context we find the temperature of black holes can be derived with important corrections. In particular given a specific MDR the temperature has a maximal value such that it can prevent black holes from total evaporation. The entropy of the (A)dS black holes is also obtained with a logarithmic correction.Comment: 10 page

Insight into the Double-Edged Role of Ferroptosis in Disease

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis

Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China

Abstract Background Staphylococcus aureus is one of the most prevalent pathogens and a causative agent of a variety of infections in humans and animals. A total of 640 samples were collected from healthy animals and patients from 2013 to 2014 in Henan Province, China, to investigate the prevalence and perform molecular characterization of S. aureus. Antimicrobial resistance and virulence genes were determined and pulsed-field gel electrophoresis (PFGE) and staphylococcal cassette chromosome mec (SCCmec) typing were performed. Results Overall, 22.3% (n = 143) of the samples were positive for S. aureus. The prevalence of methicillin-resistant S. aureus (MRSA) was 5.59%. Capsular polysaccharide locus type 5 (Cap5; 56.64%) was the dominant serotype. S. aureus strains showed high resistance to penicillin (96.50%), ciprofloxacin (52.45%), amikacin (67.83%), erythromycin (96.50%), lincomycin (97.20%), and tetracycline (68.53%) and 109 (76.2%) isolates harbored six or more tested resistance genes. The most predominant resistance genes were aphA (52.45%), ermC (53.15%), and tetM (52.45%). Eighty-seven (60.8%) isolates harbored six or more tested virulence genes. The most predominant enterotoxin genes were sed (20.28%), sej (20.98%), sep (14.69%), and set (37.76%). The prevalence of lukED gene was (57.34%), and a small number of isolates carried pvl (5.59%) and TSST-1 (2.80%). A total of 130 (82.52%) isolates could be typed by PFGE with SmaI digestion. PFGE demonstrated that 45 different patterns (P) that were grouped into 17 pulsotypes and 28 separate pulsotypes using a 90% cut-off value. A total of 118 (82.52%) isolates were successfully typed by spa, and 26 spa types were identified, t15075 (14.00%) and t189 (12.59%) were the most common types. SCCmec types were detected from eight MRSA isolates, with the most prevalent type being SCCmec IVa. MRSA-SCCmec Iva-t437 was observed in human isolates. Conclusion This study revealed a high prevalence of S. aureus in healthy animals and patients from Henan Province, China. Resistant S. aureus exhibited varying degrees of multidrug resistance. The presence of antibiotic resistance and virulence genes may facilitate the spread of S. aureus strains and pose a potential threat to public health, highlighting the need for vigilant monitoring of these isolates at the human–animal interface

Prevalence and molecular characterization of oqxAB in clinical Escherichia coli isolates from companion animals and humans in Henan Province, China

Abstract Background The plasmid-encoded multidrug efflux pump oqxAB confers bacterial resistance primarily to olaquindox, quinolones, and chloramphenicol. The aims of this study were to investigate the prevalence of oqxAB among Escherichia coli isolates from dogs, cats, and humans in Henan, China and the susceptibilities of E. coli isolates to common antibiotics. Methods From 2012 to 2014, a total of 600 samples which included 400 rectal samples and 200 clinical human specimens were tested for the presence of E. coli. All isolates were screened for oqxAB genes by PCR and sequencing. The MICs of 11 antimicrobial agents were determined by the broth microdilution method. A total of 30 representative oqxAB-positive isolates were subjected to ERIC-PCR and MLST. Additionally, conjugation experiments and southern hybridizations were performed. Results Of 270 isolates, 58.5% (62/106) of the isolates from dogs, 56.25% (36/64) of the isolates from cats, and 42.0% (42/100) of the isolates from humans were positive for the oqxAB. Olaquindox resistance was found for 85.7%-100% of oqxAB-positive isolates. Of oqxAB-positive isolates from dogs, cats, and humans, ciprofloxacin resistance was inspected for 85.8%, 59.1%, and 93.8%, respectively. Several oqxAB-positive isolates were demonstrated by ERIC-PCR and MLST, and have high similarity. Phylogenetic analysis showed that oqxAB-positive isolates could be divided into 7 major clusters. OqxAB-positive conjugants were obtained, southern hybridization verified that the oqxAB gene complex was primarily located on plasmids. Conclusion In conclusion, oqxAB-positive isolates were widespread in animals and humans in Henan, China. Carriage of oqxAB on plasmids of E. coli isolates may facilitate the emergence of multidrug resistant and its transmission via horizontal transfer, and might pose a potential threat to public health

MOESM3 of Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China

Additional file 3: Table S3. Oligonucleotide sequences, primers, and targets for polymerase chain reaction amplification of antibiotic resistance genes and integrons in S. aureus isolates

MOESM1 of Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China

Additional file 1: Table S1. Characteristics of the 143 S. aureus isolates

MOESM2 of Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China

Additional file 2: Table S2. A list of the 33 tested antimicrobials, their classes, and the concentrations used for susceptibility testing of S. aureus

MOESM4 of Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China

Additional file 4: Table S4. Oligonucleotide sequences, primers, and targets for polymerase chain reaction amplification of virulence genes in S. aureus isolates