VENTURE CAPITAL AND CORPORATE INNOVATION INPUT FROM THE PERSPECTIVE OF SYNDICATED INVESTMENT

Using data for 341 enterprises listed on the Growth Enterprise Market (GEM) of the Shenzhen Stock Exchange and taking R&D expenditure as an indicator of innovation investment, this paper implements multiple linear regression to test whether venture capital promotes corporate innovation input. It also considers the relationship between the syndicated investment of venture capital and innovation input. The results showthat venture capital indeed promotes R&D in the invested enterprises. The innovation input of syndicated investment enterprises is significantly higher than that of sole investment enterprises. Under syndicated investment, the higher the number of syndicated investment members and the greater the heterogeneity of the shareholding ratio among the members, the higher is the innovation input. The reputation of the syndicated investment team, however, has no significant impact on innovation input.Using data for 341 enterprises listed on the Growth Enterprise Market (GEM) of the Shenzhen Stock Exchange and taking R&D expenditure as an indicator of innovation investment, this paper implements multiple linear regression to test whether venture capital promotes corporate innovation input. It also considers the relationship between the syndicated investment of venture capital and innovation input. The results showthat venture capital indeed promotes R&D in the invested enterprises. The innovation input of syndicated investment enterprises is significantly higher than that of sole investment enterprises. Under syndicated investment, the higher the number of syndicated investment members and the greater the heterogeneity of the shareholding ratio among the members, the higher is the innovation input. The reputation of the syndicated investment team, however, has no significant impact on innovation input

Mesomorphic Lamella Rolling of Au in Vacuum

Lamellar nanocondensates in partial epitaxy with larger-sized multiply twinned particles (MTPs) or alternatively in the form of multiple-walled tubes (MWTs) having nothing to do with MTP were produced by the very energetic pulse laser ablation of Au target in vacuum under specified power density and pulses. Transmission electron microscopic observations revealed (111)-motif diffraction and low-angle scattering. They correspond to layer interspacing (0.241–0.192 nm) and the nearest neighbor distance (ca. 0.74–0.55 nm) of atom clusters within the layer, respectively, for the lamella, which shows interspacing contraction with decreasing particle size under the influence of surface stress and rolls up upon electron irradiation. The uncapped MWT has nearly concentric amorphous layers interspaced by 0.458–0.335 nm depending on dislocation distribution and becomes spherical onions for surface-area reduction upon electron dosage. Analogous to graphene-derived tubular materials, the lamella-derived MWT of Au could have pentagon–hexagon pair at its zig-zag junction and useful optoelectronic properties worthy of exploration

Analysis of clinical outcomes in pediatric bacterial meningitis focusing on patients without cerebrospinal fluid pleocytosis

BackgroundCerebrospinal fluid (CSF) cell count and biochemical examinations and cultures form the basis for the diagnosis of bacterial meningitis. However, some patients do not have typical findings and are at a higher risk of being missed or having delayed treatment. To better understand the correlation between CSF results and outcomes, we evaluated CSF data focusing on the patients with atypical findings.MethodsThis study enrolled CSF culture-proven bacterial meningitis patients aged from 1 month to 18 years in a medical center. The patients were divided into “normal” and “abnormal” groups for each laboratory result and in combination. The correlations between the laboratory results and the outcomes were analyzed.ResultsA total of 175 children with confirmed bacterial meningitis were enrolled. In CSF examinations, 16.2% of patients had normal white blood cell counts, 29.5% had normal glucose levels, 24.5% had normal protein levels, 10.2% had normal results in two items, and 8.6% had normal results in all three items. In logistic regression analysis, a normal CSF leukocyte count and increased CSF protein level were related to poor outcomes. Patients with meningitis caused by Streptococcus pneumoniae and hyponatremia were at a higher risk of mortality and the development of sequelae.ConclusionsIn children with bacterial meningitis, nontypical CSF findings and, in particular, normal CSF leukocyte count and increased protein level may indicate a worse prognosis

Light absorption properties of brown carbon over the southeastern Tibetan Plateau

We present a study of the light-absorbing properties of water-soluble brown carbon (WS-BrC) and methanolsoluble brown carbon (MeS-BrC) at a remote site (Lulang, 3326 m above sea level) in the southeastern Tibetan Plateau during the period 2015-2016. The light absorption coefficients at 365 nm (b(abs365)) of WS-BrC and MeS-BrC were the highest during winter and the lowest during monsoon season. MeS-BrC absorbs about 1.5 times higher at 365 nm compared to WS-BrC. The absorption at 550 nm appears lower compared to that of 365 nm for WS-BrC and MeS-BrC, respectively. Higher average value of the absorption Angstrom exponent (AAE, 365-550 nm) was obtained for MeS-BrC (8.2) than that for WS-BrC (6.9). The values of the mass absorption cross section at 365 nm (MAC(365)) indicated that BrC in winter absorbs UV-visible light more efficiently than in monsoon. The results confirm the importance of BrC in contributing to light-absorbing aerosols in this region. The understanding of the light absorption properties of BrC is of great importance, especially in modeling studies for the climate effects and transport of BrC in the Tibetan Plateau. (c) 2017 Elsevier B.V. All rights reserved

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L. Chen; 81101026 to Y. Huang; 31528011 to B. Lang; 81221001, 91232724 and 81571332 to Y-Q. Ding), Zhejiang Province Natural Science Foundation of China (LQ13C090004 to C. Zhang), China Postdoctoral Science Foundation (2016 M591714 to C.-C. Qi), and the Fundamental Research Funds for the Central Universities (2013KJ049).Peer reviewedPublisher PD

Glycan Sequence‐Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library

Nucleotide oligomerization domain‐containing protein 2 (Nod2), an innate immune receptor, recognizes bacterial cell‐wall peptidoglycan (PGN), the minimum ligand of which is muramyl dipeptide (MDP). Enzymatic digestion of PGN appears to be important for Nod2 recognition. PGN is degraded by muramidase or glucosamidase through a process that produces two types of glycan sequence; glycans containing GlcNAcβ(1→4)MurNAc or MurNAcβ(1→4)GlcNAc. In this report, a range of disaccharide or tetrasaccharide fragments of each sequence were chemically synthesized, and their activities in stimulating human Nod2 (hNod2) were investigated. The results reveal that hNod2 recognitions is dependent on the glycan sequence, as demonstrated by comparing the activities of glycans with the same peptide moieties. (MurNAcβ(1→4)GlcNAc) 2 ‐containing structures exhibited stronger activity than those containing (GlcNAcβ(1→4)MurNAc) 2 . The results suggest that differences in the enzymatic degradation process affect the host's immunomodulation process. To Nod off or on? Di‐ or tetrasaccharide fragments of muramidase and glucosamidase were chemically synthesized, and their abilities to stimulate human Nod2 were investigated. The results reveal that hNod2 recognition is glycan sequence‐dependent, and suggest that the peptidoglycan degradation process affects the host's immunomodulation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96737/1/cbic_201200655_sm_miscellaneous_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/96737/2/482_ftp.pd

DEXON: A Highly Scalable, Decentralized DAG-Based Consensus Algorithm

A blockchain system is a replicated state machine that must be fault tolerant. When designing a blockchain system, there is usually a trade-off between decentralization, scalability, and security. In this paper, we propose a novel blockchain system, DEXON, which achieves high scalability while remaining decentralized and robust in the real-world environment. We have two main contributions. First, we present a highly scalable sharding framework for blockchain. This framework takes an arbitrary number of single chains and transforms them into the \textit{blocklattice} data structure, enabling \textit{high scalability} and \textit{low transaction confirmation latency} with asymptotically optimal communication overhead. Second, we propose a single-chain protocol based on our novel verifiable random function and a new Byzantine agreement that achieves high decentralization and low latency

Implications for new physics from Bˉ0→π0π0{\bar B}^0\to \pi^0\pi^0 and Bˉ0→Kˉ0K0{\bar B}^0\to {\bar K}^0K^0

We have analyzed the ${\bar B}^0\to \pi^0\pi^0$ puzzle in three kinds of models beyond the standard model (SM). It is shown that the minimal flavor violation (MFV) models, the minimal supersymmetric standard model (MSSM), and the two Higgs doublet models (2HDM) I and II can not give an explanation of the ${\bar B}^0\to \pi^0\pi^0$ puzzle within $1 \sigma$ experimental bounds and the model III 2HDM can explain the puzzle without a conflict with other experimental measurements. If the constraint on $C_{8g}$ from $b\to s g$ is not imposed, for all kinds of insertions considered there are regions of parameter space, where the scalar quark mass is larger (much larger) than the gluino mass in the case of LR or RL (LL or RR), in which the puzzle can be resolved within $1 \sigma$ experimental bounds.Comment: 7 pages, 3 eps files. Add some more explicit analysis version appeared in PL