Domestic Violence (DV) Screening

Domestic Violence (DV) is an understated yet significant source of morbidity and mortality for victims. Healthcare providers have a unique opportunity and responsibility to identify patients who may be victims of DV. A formal screening method for DV should be developed and routinely employed in local practices to address this issue.https://scholarworks.uvm.edu/fmclerk/1518/thumbnail.jp

A comparison of three heuristics to choose the variable ordering for CAD

Cylindrical algebraic decomposition (CAD) is a key tool for problems in real algebraic geometry and beyond. When using CAD there is often a choice over the variable ordering to use, with some problems infeasible in one ordering but simple in another. Here we discuss a recent experiment comparing three heuristics for making this choice on thousands of examples

Direct Evidence from Spitzer for a low-luminosity AGN at the center of the Elliptical Galaxy NGC 315

We present the {\it Spitzer} Space Telescope InfraRed Array Camera (IRAC) and Multiband Imaging Photometer (MIPS) observations of the elliptical galaxy NGC 315. After removal of the host galaxy's stellar emission, we detected for the first time an infrared-red nucleus in NGC 315. We measured the spectral energy distribution (SED) for this active nucleus with wavelength range covering from radio to X-ray, and obtained the bolometric luminosity of $\rm L_{bol} \approx 1.9 \times 10^{43} ergs s^{-1}$, corresponding to an extremely low Eddington ratio (L/L$_{\rm Edd}$) of 4.97 $\times$ 10$^{-4}$. Our results confirm that the physical nature of the nucleus of NGC 315 is a low-luminosity AGN, consistent with the recent optical and {\it Chandra} X-ray observations.Comment: 4 pages, accepted for publication in ApJ Letter

Quasi-ballistic electron transport in double-wall carbon nanotubes

Room-temperature quasi-ballistic electron transport in double-wall carbon nanotubes (DWNT) is demonstrated. Conductance dependence on the length was measured by submerging DWNTs into liquid mercury. The conductance plots show plateaus, indicating weak dependence of the electrode-tube-electrode electrical resistance on the length of the connecting nanotube. We infer a mean free path between 0.6 and 10 micron meters for around 80% of the DWNTs, which is in good agreement with calculations based on the electron scattering by acoustic phonons and by disorder

Cardiotonic Modulation in Heart Failure Insights From Traditional Chinese Medicine∗

Medicinal herbs have been used over the past centuries for restoring the body's homeostatic balance. Contemporary use of herbal supplements remains widespread in many cultures as treatment for specific ailments. Many possess cardiovascular actions, and some interact with cardiac medications. However, there is variable scientific evidence with respect to their safety and efficacy, and few have been subjected to the same rigorous evaluation processes and regulations as contemporary pharmaceuticals (1). In the field of heart failure, we have also witnessed the failure of promising naturopathic therapies like hawthorn extract in translating their potential benefits in rigorous clinical trials (2,3)

Health and Nutrition in Vermont Children

Introduction. The AHA (American Heart Association) supports legislation in Ver- mont ensuring that restaurants’ children’s menu meals meet certain nutritional standards. This study investigated Vermont parents’ attitudes towards both dining at restaurants with their children and potential legislation to improve nutritional standards of restaurant food. Methods. An anonymous 21-question survey for parents with children under age 18 was distributed electronically to local organizations via Facebook groups and email, and as paper questionnaires at the Community Health Center of Burlington. Questions probed parents’ overall attitudes surrounding their children’s health, habits pertaining to eating at restaurants, and attitudes towards legislation to ensure healthier options for kids at restaurants. Results were analyzed to look for dominant themes and determine differences between subgroups. Results. 98% of survey participants agreed or strongly agreed that their children’s eating habits are important to them. When asked if they would support legislation to set nutrition standards on children’s menu meals in Vermont, 73% agreed or strongly agreed. Most survey participants eat at a restaurant once per week or less (95%). 53% of survey participants agreed or strongly agreed that there were enough restaurants with healthy kids’ meals in their area. Responses did not differ by county. Conclusion. Vermont parents are concerned about their children’s diets and acknowledge connections between nutrition, obesity, and overall health. Parents favor restaurants providing more nutritional items on children’s menus and support the AHA’s proposed standards. Next steps include investigating any financial impact on restaurants and studying nutritional standards in school cafeterias in Vermont.https://scholarworks.uvm.edu/comphp_gallery/1257/thumbnail.jp

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

Tachyzoite to bradyzoite development in Toxoplasma is marked by major changes in gene expression resulting in a parasite that expresses a new repertoire of surface antigens hidden inside a modified parasitophorous vacuole called the tissue cyst. The factors that control this important life cycle transition are not well understood. Here we describe an important transcriptional repressor mechanism controlling bradyzoite differentiation that operates in the tachyzoite stage. The ApiAP2 factor, AP2IV-4, is a nuclear factor dynamically expressed in late S phase through mitosis/cytokinesis of the tachyzoite cell cycle. Remarkably, deletion of the AP2IV-4 locus resulted in the expression of a subset of bradyzoite-specific proteins in replicating tachyzoites that included tissue cyst wall components BPK1, MCP4, CST1 and the surface antigen SRS9. In the murine animal model, the mis-timing of bradyzoite antigens in tachyzoites lacking AP2IV-4 caused a potent inflammatory monocyte immune response that effectively eliminated this parasite and prevented tissue cyst formation in mouse brain tissue. Altogether, these results indicate that suppression of bradyzoite antigens by AP2IV-4 during acute infection is required for Toxoplasma to successfully establish a chronic infection in the immune-competent host

Regularization strategy for the layered inversion of airborne TEM data: application to VTEM data acquired over the basin of Franceville (Gabon)

Airborne transient electromagnetic (TEM) is a cost-effective method to image the distribution of electrical conductivity in the ground. We consider layered earth inversion to interpret large data sets of hundreds of kilometre. Different strategies can be used to solve this inverse problem. This consists in managing the a priori information to avoid the mathematical instability and provide the most plausible model of conductivity in depth. In order to obtain fast and realistic inversion program, we tested three kinds of regularization: two are based on standard Tikhonov procedure which consist in minimizing not only the data misfit function but a balanced optimization function with additional terms constraining the lateral and the vertical smoothness of the conductivity; another kind of regularization is based on reducing the condition number of the kernel by changing the layout of layers before minimizing the data misfit function. Finally, in order to get a more realistic distribution of conductivity, notably by removing negative conductivity values, we suggest an additional recursive filter based upon the inversion of the logarithm of the conductivity. All these methods are tested on synthetic and real data sets. Synthetic data have been calculated by 2.5D modelling; they are used to demonstrate that these methods provide equivalent quality in terms of data misfit and accuracy of the resulting image; the limit essentially comes on special targets with sharp 2D geometries. The real data case is from Helicopter-borne TEM data acquired in the basin of Franceville (Gabon) where borehole conductivity loggings are used to show the good accuracy of the inverted models in most areas, and some biased depths in areas where strong lateral changes may occur

Anisotropic molecular coarse-graining by force and torque matching with neural networks

We develop a machine-learning method for coarse-graining condensed-phase molecular systems using anisotropic particles. The method extends currently available high-dimensional neural network potentials by addressing molecular anisotropy. We demonstrate the flexibility of the method by parametrizing single-site coarse-grained models of a rigid small molecule (benzene) and a semi-flexible organic semiconductor (sexithiophene), attaining structural accuracy close to the all-atom models for both molecules at considerably lower computational expense. The machine-learning method of constructing the coarse-grained potential is shown to be straightforward and sufficiently robust to capture anisotropic interactions and many-body effects. The method is validated through its ability to reproduce the structural properties of the small molecule's liquid phase and the phase transitions of the semi-flexible molecule over a wide temperature range.Comment: 13 pages + 8 pages supplementary material, 13 figure

A Lie-Algebraic Approach To the Kondo Problem

The Kondo problem is studied using the unitary Lie algebra of spin-singlet fermion bilinears. In the limit when the number of values of the spin $N$ goes to infinity the theory approaches a classical limit, which still requires a renormalization. We determine the ground state of this renormalized theory. Then we construct a quantum theory around this classical limit, which amounts to recovering the case of finite $N$.Comment: 3 figure