Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics.

An increasing number of psychoradiology studies that use tract-based spatial statistics (TBSS) of diffusion tensor imaging have reported abnormalities of white matter in patients with bipolar disorder; however, robust conclusions have proven elusive, especially considering some important clinical and demographic factors. In the present study, we performed a quantitative meta-analysis of TBSS studies to elucidate the most consistent white-matter abnormalities in patients with bipolar disorder.We conducted a systematic search up to May 2017 for all TBSS studies comparing fractional anisotropy (FA) between patients with bipolar disorder and healthy controls. We performed anisotropic effect size-signed differential mapping meta-analysis.We identified a total of 22 data sets including 556 patients with bipolar disorder and 623 healthy controls. We found significant FA reductions in the genu and body of the corpus callosum in patients with bipolar disorder relative to healthy controls. No regions of increased FA were reported. In subgroup analyses, the FA reduction in the genu of the corpus callosum retained significance in patients with bipolar disorder type I, and the FA reduction in the body of the corpus callosum retained significance in euthymic patients with bipolar disorder. Meta-regression analysis revealed that the percentage of female patients was negatively correlated with reduced FA in the body of the corpus callosum.Data acquisition, patient characteristics and clinical variables in the included studies were heterogeneous. The small number of diffusion tensor imaging studies using TBSS in patients with bipolar disorder type II, as well as the lack of other clinical information, hindered the application of subgroup meta-analyses.Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder

High-Accuracy and Real-Time Indoor Positioning System Based on Visible Light Communication and Mobile Robot

For mobile robots and location-based services, precise and real-time positioning is one of the most basic capability, and low-cost positioning solutions are increasingly in demand and have broad market potential. In this paper, we innovatively design a high-accuracy and real-time indoor localization system based on visible light positioning (VLP) and mobile robot. First of all, we design smart LED lamps with VLC and Bluetooth control functions for positioning. The design of LED lamps includes hardware design and Bluetooth control. Furthermore, founded on the loose coupling characteristics of ROS (Robot Operator System), we design a VLP-based robot system with VLP information transmitted by designed LED, dynamic tracking algorithm of high robustness, LED-ID recognition algorithm, and triple-light positioning algorithm. We implemented the VLP-based robot positioning system on ROS in an office equipped with the designed LED lamps, which can realize cm-level positioning accuracy of 3.231 cm and support the moving speed up to 20 km/h approximately. This paper pushes forward the development of VLP application in indoor robots, showing the great potential of VLP for indoor robot positioning