1,774 research outputs found
Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review.
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. AHO investigation can be divided into structural and functional assessments using different methods. The historical basis for studying the anterior segment of the eye and AHO in glaucoma is discussed. Structural studies of AHO are reviewed and include traditional pathological approaches to modern tools such as multi-model two-photon microscopy and optical coherence tomography. Functional assessment focuses on visualizing AHO itself through a variety of non-real-time and real-time techniques such as aqueous angiography. Implications of distal outflow resistance and segmental AHO are discussed with an emphasis on melding bench-side research to viable clinical applications. Through the development of an improved structure: function relationship for AHO in the anterior segment of the normal and diseased eye, a better understanding of the eye with improved therapeutics may be developed
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Giant Light-Emission Enhancement in Lead Halide Perovskites by Surface Oxygen Passivation.
Surface condition plays an important role in the optical performance of semiconductor materials. As new types of semiconductors, the emerging metal-halide perovskites are promising for next-generation optoelectronic devices. We discover significantly improved light-emission efficiencies in lead halide perovskites due to surface oxygen passivation. The enhancement manifests close to 3 orders of magnitude as the perovskite dimensions decrease to the nanoscale, improving external quantum efficiencies from <0.02% to over 12%. Along with about a 4-fold increase in spontaneous carrier recombination lifetimes, we show that oxygen exposure enhances light emission by reducing the nonradiative recombination channel. Supported by X-ray surface characterization and theoretical modeling, we propose that excess lead atoms on the perovskite surface create deep-level trap states that can be passivated by oxygen adsorption
Pathways in Two-State Protein Folding
The thermodynamics of proteins indicate that folding/unfolding takes place
either through stable intermediates or through a two-state process without
intermediates. The rather short folding times of the two-state process indicate
that folding is guided. We reconcile these two seemingly contradictory
observations quantitatively in a schematic model of protein folding. We propose
a new dynamical transition temperature which is lower than the thermodynamic
one, in qualitative agreement with in vivo measurement of protein stability
using E.coli. Finally we demonstrate that our framework is easily generalized
to encompass cold unfolding, and make predictions that relate the sharpness of
the cold and hot unfolding transitions.Comment: 4 pages RevTeX, 5 Postscript figur
ELF3 controls thermoresponsive growth in Arabidopsis
Plant development is highly responsive to ambient temperature, and this trait has been linked to the ability of plants to adapt to climate change [1]. The mechanisms by which natural populations modulate their thermoresponsiveness are not known [2]. To address this, we surveyed Arabidopsis accessions for variation in thermal responsiveness of elongation growth and mapped the corresponding loci. We find that the transcriptional regulator EARLY FLOWERING3 (ELF3) controls elongation growth in response to temperature. Through a combination of modeling and experiments, we show that high temperature relieves the gating of growth at night, highlighting the importance of temperature-dependent repressors of growth. ELF3 gating of transcriptional targets responds rapidly and reversibly to changes in temperature. We show that the binding of ELF3 to target promoters is temperature dependent, suggesting a mechanism where temperature directly controls ELF3 activity
Spin-polarization-induced structural selectivity in Pd and Pt () compounds
Spin-polarization is known to lead to important {\it magnetic} and {\it
optical} effects in open-shell atoms and elemental solids, but has rarely been
implicated in controlling {\it structural} selectivity in compounds and alloys.
Here we show that spin-polarized electronic structure calculations are crucial
for predicting the correct crystal structures for Pd and Pt
compounds. Spin-polarization leads to (i) stabilization of the structure
over the structure in PtCr, PdCr, and PdMn, (ii) to the
stabilization of the structure over the structure in PdCo
and to (iii) ordering (rather than phase-separation) in PtCo and PdCr.
The results are analyzed in terms of first-principles local spin density
calculations.Comment: 4 pages, REVTEX, 3 eps figures, to appear in PR
Generation of continuous variable squeezing and entanglement of trapped ions in time-varying potentials
We investigate the generation of squeezing and entanglement for the motional
degrees of freedom of ions in linear traps, confined by time-varying and
oscillating potentials, comprised of an DC and an AC component. We show that
high degrees of squeezing and entanglement can be obtained by controlling
either the DC or the AC trapping component (or both), and by exploiting
transient dynamics in regions where the ions' motion is unstable, without any
added optical control. Furthermore, we investigate the time-scales over which
the potentials should be switched in order for the manipulations to be most
effective.Comment: 10 pages, submitted to Quantum Information Processing (special issue
on Quantum Decoherence and Entanglement
All-organic and organic-silicon photonic ring micro-resonators
Organic electro-optic materials offer exceptional processability (both from solution and the gas phase) that permit fabrication of flexible and conformal device structures and the integration of organic materials with a wide range of disparate materials. In addition, organic electro-optical materials have fundamental response times that are in the terahertz region, and useable electro-optic coefficients that are approaching 300 pm/V (at telecommunication wavelengths). In addition to fabrication by traditional lithographic methods, multiple devices on a single wafer have been fabricated by soft and nano-imprint lithography. In this presentation, we review the fabrication and performance evaluation of a number of all-organic and organic-silicon photonic ring microresonator devices. Both electrical and thermal tuning of devices, including both single and multiple ring micro-resonators, are demonstrated
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