High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation

Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0.45 MPa and 10 Hz with 10% duty cycle), PUT with 4 mJ/cm2 and 6 mJ/cm2 laser fluence induced 51% (p = 0.001) and 37% (p = 0.018) vessel diameter reductions respectively. With 8 mJ/cm2 laser fluence, PUT would yield vessel disruption (90%, p < 0.01). Selectivity of PUT was demonstrated by utilizing laser wavelengths at 578 nm or 650 nm, where PUT selectively shrank veins or occluded arteries. In a rabbit ear model, PUT induced a 68.5% reduction in blood perfusion after 7 days (p < 0.001) without damaging the surrounding cells. In vitro experiments in human blood suggested that cavitation may play a role in PUT. In conclusion, PUT holds significant promise as a novel non-invasive antivascular method with the capability to precisely target blood vessels.R01AR060350R01CA1867694K12EY022299-4BL2014089

Can fiscal expenditure for agriculture mitigate the impact of climate change on agricultural production?

The profound impact of climate change on agricultural production, and the government’s fiscal expenditure for agriculture, is considered a crucial means to address this challenge. This study utilizes panel data from all prefecture-level cities in Heilongjiang Province from 2000 to 2020. Drawing upon the Cobb–Douglas production function, an economic climate model is constructed to empirically analyze the impact of climate change on grain yield in Heilongjiang Province. Furthermore, the role of fiscal expenditure for agriculture in mitigating the effects of climate change on grain yield is explored. Feasible Generalized Least Squares (FGLS) estimation is employed to address issues of “heteroscedasticity,” “autocorrelation within groups,” and “cross-sectional contemporaneous correlation” present in the model. The results indicate that climate change has a positive impact on rice and corn yields, while exhibiting a negative impact on wheat yield. The influence of climate change on crop yield is both linear and nonlinear. Specifically, temperature demonstrates a linear relationship with rice and corn yields, whereas precipitation shows a significant inverted U-shaped relationship with rice and corn yields. The impact of climate change on grain production in Heilongjiang Province varies significantly across regions. Fiscal expenditure for agriculture has a significant positive effect on the yield of major grain crops in Heilongjiang Province. In addressing the impact of climate change on grain production, agricultural fiscal expenditure enhances the positive effect of precipitation on rice and corn yields, while diminishing the positive impact of temperature on corn yield

Occurrence of False Positive Results for the Detection of Carbapenemases in Carbapenemase-Negative Escherichia coli and Klebsiella pneumoniae Isolates

Adequate detection of the production of carbapenemase in Enterobacteriaceae isolates is crucial for infection control measures and the appropriate choice of antimicrobial therapy. In this study, we investigated the frequency of false positive results for the detection of carbapenemases in carbapenemase-negative Escherichia coli and Klebsiella pneumoniae clinical isolates by the modified Hodge test (MHT). Three hundred and one E. coli and K. pneumoniae clinical isolates were investigated. All produced extended spectrum β-lactamases (ESBLs) but were susceptible to carbapenems. Antimicrobial susceptibility testing was performed by the disk diffusion and agar dilution methods. The MHT was performed using the standard inoculum of test organisms recommended by the CLSI. Genes that encoded ESBLs and carbapenemases were identified by PCR and DNA sequencing. Among the 301 clinical isolates, none of the isolates conformed to the criteria for carbapenemase screening recommended by the CLSI. The susceptibility rates for imipenem, meropenem, and ertapenem all were 100.0%, 100.0%, and 100.0%, respectively. Of the 301 E. coli and K. pneumoniae isolates, none produced carbapenemase. The MHT gave a positive result for 3.3% (10/301) of the isolates. False positive results can occur when the MHT is used to detect carbapenemase in ESBL-producing isolates and clinical laboratories must be aware of this fact

African Swine Fever Shock: China’s Hog Industry’s Resilience and Its Influencing Factors

African swine fever has damaged the foundation of China’s hog industry, caused a serious decline in hog production, highlighted the contradiction between supply and demand in the pork market, and led to major economic and social impacts. The industrial resilience of 31 Chinese provinces to African swine fever shock and its spatial and temporal differentiation characteristics from 2018 to 2021 were measured in this study from the two dimensions of resistance and recoverability. Using Geodetector, the key factors influencing the resilience of China’s hog industry were explored. The results showed that 2018–2019 and 2020–2021 represented the resistance and recovery periods of the hog industry under African swine fever shock, respectively, with poor resilience characterizing the resistance period and improved resilience characterizing the recovery period. At the early stages of the African swine fever outbreak, the hog industries in Tianjin, Shanxi, Guangxi, and Yunnan had robust resistance due to the slaughter rate, economic level, mortality rate, carcass weight, and culling rate in those areas. At the most severe stage of the outbreak, resistance was generally poor in all provinces due to the slaughter rate, per capita consumption, and scale level at the time. During the period of rapid recovery in hog production, the recoverability of each province was very strong due to the industrial structure, culling rate, economic level, and resource carrying capacity at that time. During the reasonable adjustment period of hog production capacity, the recoverability based on the breeding sow inventory in 13 provinces, including Henan, Shandong, and other large hog-breeding provinces, was negative due to the scale level, slaughter rate, per capita consumption, and resource carrying at that time. Taking measures to enhance the resilience of the hog industry, strengthen the prevention and control of hog epidemics, improve the monitoring and early warning mechanisms, and enhance the ability of the hog industry to cope with major animal epidemics is recommended

Description of two new species of the leafhopper subgenus Pediopsoides (Pediopsoides) (Hemiptera, Cicadellidae, Macropsinae) from Guangxi Province, Southern China

Two new species of the Macropsinae leafhopper subgenus Pediopsoides (Pediopsoides) Matsumura, 1912, P. (P.) damingshanensis Li, Dai & Li, sp. n. and P. (P.) tishetshkini Li, Dai & Li sp. n., are described and illustrated from Guangxi Province of southern China. A key to males is provided to distinguish the species of the subgenus along with a map showing the distribution of the new species

Notes on the genus Pedionis Hamilton (Hemiptera, Cicadellidae, Macropsinae), and with description of two new species from China

Two new species Pedionis (Pedionis) nankunshanensis Li, Dai & Li sp. n. and P. (P.) tabulatus Li, Dai & Li sp. n. from China are described and illustrated. A key is given to separate all species of this genus (except P. (P.) oeroe and P. (P.) thyia)

Risk Assessment and Response Strategy for Pig Epidemics in China

Strengthening the analysis and risk assessment of the pig epidemic will help to better prevent and mitigate epidemic risks and promote the high-quality development of the pig industry. Based on a systematic understanding of live pig epidemics, a risk assessment index system was constructed, and the spatial and temporal variation characteristics of pig epidemics in China were explored by the entropy method. In recent years, the overall trend in pig epidemics over time first increased and then decreased; in space, the acceleration of the spread of epidemics across the country weakened. China still faces challenges, including many types and a wide range of diseases, large total livestock breeding and weak epidemic prevention and control capacity, and a large risk of introduced foreign animal epidemics. The spatial and temporal variations in the pig epidemic risk were obvious; one high-risk area, two medium–high-risk areas and 10 medium-risk areas have been found in recent years, during which time, the epidemic risk was highest in Beijing, Hainan, Liaoning, Tibet and Zhejiang. However, there were significant differences in the regional distribution of the risk level of pig epidemics in different years. To further build a secure “defense system” for the high-quality development of the pig industry, it is recommended to improve the monitoring and early warning system of pig epidemic risk, perfect the pig epidemic prevention and control system, and strengthen the regional collaboration mechanism of epidemic prevention and control

Description of two new species of the leafhopper subgenus Pediopsoides (Pediopsoides) (Hemiptera, Cicadellidae, Macropsinae) from Guangxi Province, Southern China

Two new species of the Macropsinae leafhopper subgenus Pediopsoides (Pediopsoides) Matsumura, 1912, P. (P.) damingshanensis Li, Dai & Li, sp. n. and P. (P.) tishetshkini Li, Dai & Li sp. n., are described and illustrated from Guangxi Province of southern China. A key to males is provided to distinguish the species of the subgenus along with a map showing the distribution of the new species

Description of two new species of the leafhopper subgenus Pediopsoides (Pediopsoides) (Hemiptera, Cicadellidae, Macropsinae) from Guangxi Province, Southern China

Two new species of the Macropsinae leafhopper subgenus Pediopsoides (Pediopsoides) Matsumura, 1912, P. (P.) damingshanensis Li, Dai & Li, sp. n. and P. (P.) tishetshkini Li, Dai & Li sp. n., are described and illustrated from Guangxi Province of southern China. A key to males is provided to distinguish the species of the subgenus along with a map showing the distribution of the new species