The Efficacy and Safety of Nicorandil for Periprocedural Myocardial Injury in Patients Undergoing PCI: A Meta-Analysis

Purpose. To evaluate the efficacy and safety of nicorandil for periprocedural myocardial injury in patients undergoing PCI through meta-analysis of randomized controlled trials. Methods. We analyzed the clinical data of patients including the incidence of periprocedural myocardial injury (PMI) and major adverse cardiovascular events (MACE) from selected articles. RCTs were retrieved from medical literature databases. RR and 95% confidence intervals (CI) were calculated to compare the endpoints. Results. In total, 15 articles (16 trial comparisons) were retrieved which contained 2221 patients. In general, 1130 patients (50.9%) were randomized to the experimental group, whereas 1091 patients (49.1%) were randomized to the control group. The result showed that nicorandil significantly reduced the incidence of PMI and MACE after PCI compared to the control group. Conclusions. Overall, early use of nicorandil in patients undergoing percutaneous coronary intervention (PCI) was associated with a significant reduction of PMI and MACE

Spatial–seasonal characteristics and influencing factors of dissolved organic carbon and chromophoric dissolved organic matter in Poyang Lake

As the largest organic carbon pool in water, dissolved organic carbon (DOC) plays a key role in the carbon cycle. In inland rivers and lakes, DOC is closely related to chromophoric dissolved organic matter (CDOM) with optical attenuation. In this study, the spatial distribution and seasonal variations of DOC and CDOM in Poyang Lake in 2014–2016 were investigated. The results demonstrated that the DOC concentration in Poyang Lake had a range of 1.34–5.56 mg/L with an average of 2.12 ± 0.54 mg/L. The absorption coefficient of CDOM at 355 nm had a range of 1.24–5.70 m−1 with an average of 2.71 ± 0.83 m−1. In terms of the spatial distribution, the concentrations of DOC and CDOM in the south of Poyang Lake were higher than those in the north of the lake. In terms of seasonal variations, the concentrations of DOC and CDOM were higher in spring and summer than in autumn and winter. The absorption coefficients of CDOM and DOC concentrations in Poyang Lake exhibited a significant linear correlation. The correlation between DOC and CDOM in some sections of Poyang Lake varied spatially and seasonally. The highest correlation was observed in wetland waters of the southern Poyang Lake in spring, while there was no significant correlation in northern section of the lake in most of the periods. The results revealed that water level, precipitation and the vegetation cover pattern had determining effects on the spatial heterogeneity of DOC and CDOM. The spectral characteristic parameters demonstrated that the main source of the CDOM in Poyang Lake was from terrestrial input

Optical Absorption Characteristics, Spatial Distribution, and Source Analysis of Colored Dissolved Organic Matter in Wetland Water around Poyang Lake

Colored dissolved organic matter (CDOM) is an important part of aquatic ecosystems and plays a key role in the biogeochemical cycle. In this study, CDOM absorption spectrum curves and water quality parameters from 30 sampling sites in the wetlands of Poyang Lake, Jiangxi Province, China, were collected in October 2016. The optical absorption characteristics and spatial distribution of CDOM, the correlation between the absorption coefficient of CDOM at a wavelength of 355 nm (ag(355)), and the concentration of dissolved organic carbon (DOC) were analyzed. Spectral characteristic parameters—namely, E2/E3 (the ratio of the CDOM absorption coefficient at a wavelength of 250 nm to the CDOM absorption coefficient at a wavelength of 365 nm), SUVA254 (the ratio of the CDOM absorption coefficient at a wavelength of 254 nm to the DOC concentration), and spectral slopes—were used to infer the composition and sources of CDOM in the Poyang Lake wetlands. The results showed the following: (1) the CDOM absorption spectrum of water of the Poyang Lake wetlands presented significant spatial variation, showing a trend of south > west > north > east; (2) there was a strong linear correlation between the CDOM absorption coefficient and the DOC concentration in the water of the Poyang Lake wetlands (ag(355) = 1.075DOC–0.659 (r2 = 0.723, p n = 30)); (3) the analysis of the spectral characteristic parameters E2/E3, SUVA254, and spectral slopes showed that the CDOM in the Poyang Lake wetlands has relatively high aromaticity and molecular weight, which were shown to be mainly affected by terrestrial inputs. The results showed that the molecular weight and aromaticity of CDOM were higher in the south of the lake than in other parts

Plant-mediated methane and nitrous oxide fluxes from a carex meadow in Poyang Lake during drawdown periods

Aims: Plants have been suggested to have significant effects on methane (CH4) and nitrous oxide (N2O) fluxes from littoral wetlands, but it remains unclear in subtropical lakes. Methods: We conducted in situ measurement of CH4 and N2O fluxes for two years. To distinguish between the effects of shoots and roots, three treatments (i.e., intact plants as control, shoot clipping, and root exclusion) were used. Effects of plant biomass, temperature, and soil moisture on CH4 and N2O fluxes were analyzed. Results: The mean ecosystem CH4 emission rate was 36 μg CH4 m−2 h−1 for drying periods, but 8219 μg CH4 m−2 h−1 for drying-wetting transition periods. CH4 fluxes were positively correlated with below-ground and total biomass, but not with above-ground biomass. Clipping did not significantly alter CH4 flux rate, but root exclusion decreased the CH4 flux by 116 % as compared to the control. N2O emissions were similar for both the drying and drying-wetting transition periods, with a mean rate of 20 μg N2O m−2 h−1. Both clipping and root exclusion significantly increased N2O fluxes as compared to the control. Conclusions: There was no significant correlation between CH4 and N2O fluxes. Roots dominated plant-mediated enhancement in CH4 fluxes, but played almost an equal role as shoots in plant-regulated suppression on N2O fluxes in this Carex meadow during drawdown periods

Effects of Elevated CO2 Concentration and Nitrogen Addition on Soil Respiration in a Cd-Contaminated Experimental Forest Microcosm

Forests near rapidly industrialized and urbanized regions are often exposed to elevated CO2, increased N deposition, and heavy metal pollution. To date, the effects of elevated CO2 and/or increased N deposition on soil respiration (Rs) under heavy metal contamination are unclear. In this study, we firstly investigated Rs in Cd-contaminated model forests with CO2 enrichment and N addition in subtropical China. Results showed that Rs in all treatments exhibited similar clear seasonal patterns, with soil temperature being a dominant control. Cadmium addition significantly decreased cumulative soil CO2 efflux by 19% compared to the control. The inhibition of Rs caused by Cd addition was increased by N addition (decreased by 34%) was partially offset by elevated CO2 (decreased by 15%), and was not significantly altered by the combined N addition and rising CO2. Soil pH, microbial biomass carbon, carbon-degrading hydrolytic enzymes, and fine root biomass were also significantly altered by the treatments. A structural equation model revealed that the responses of Rs to Cd stress, elevated CO2, and N addition were mainly mediated by soil carbon-degrading hydrolytic enzymes and fine root biomass. Overall, our findings indicate that N deposition may exacerbate the negative effect of Cd on Rs in Cd-contaminated forests and benefit soil carbon sequestration in the future at increasing atmospheric CO2 levels

Mechanochemical Synthesis of Dolomite-Related Carbonates—Insight into the Effects of Various Parameters

The low-temperature formation of dolomite (CaMg(CO3)2) is undoubtedly a long and interesting geological problem, which has troubled many researchers for centuries to explore the formation of dolomite. Recently, efforts have been made by synthesizing dolomite analogues such as norsethite (BaMg(CO3)2), PbMg(CO3)2, with Ba and Pb to replace Ca and investigating their reaction pathways. In this study, we reported our efforts to synthesize dolomite-related complex carbonates by using the mechanical ball milling method as a new approach to control the solid–water ratio compared to the commonly used solution method. Two analogues of norsethite and PbMg(CO3)2 have been simply obtained even at stoichiometric molar ratio of Ba/Mg = 1:1 and Pb/Mg = 1:1 with various parameters examined; and product properties including morphology and phase compositions were investigated by a range of techniques, including XRD, SEM-EDS, and FTIR. Finally, we attempted to synthesize dolomite and compared the differences from the synthesis of analogues. In conclusion, we have synthesized norsethite and PbMg(CO3)2 in one step by the ball milling method, which greatly reduces the reaction time compared with the conventional solution method and may provide other choices for the formation of dolomite

A Comprehensive Multi-Metric Index for Health Assessment of the Poyang Lake Wetland

The Poyang Lake wetland is home to many unique and threatened species. However, it has been severely degraded in recent decades due to the joint effects of human influence and climate change. Here we establish a wetland health index (WHI) for Poyang Lake, which considers five types of attributes (biological, water quality, sediment, land use and remote sensing, and socio-economic attributes) of the wetland to evaluate wetland conditions. Forty-nine variables across five categories were assembled as candidate metrics for the WHI through field surveys conducted in 2019 at 30 sample sites. Principal component analyses were performed to identify the most important variables in each of the five categories as the primary metrics of each index category (e.g., biological index). Eighteen variables were finally selected from the five categories to construct the WHI. The WHI scores varied from 0.34 to 0.80 at the 30 sample sites, with a mean of 0.55. The Poyang Lake wetland is generally in fair condition according to our WHI scores. Sample sites where connected rivers flow into the lake were assessed to be in a poor condition, highlighting the importance of reducing pollution input from rivers for wetland conservation. Scores of individual indices of the five categories were not highly correlated (0.29 ≤ pairwise Spearman’s r ≤ 0.69), suggesting that information provided by each index is different and might be complementary. The composite WHI as well as the individual category indices can provide comprehensive information on wetland conditions that would facilitate the development of more targeted and effective strategies for wetland management

Seasonal flooding wetland expansion would strongly affect soil and sediment organic carbon storage and carbon-nutrient stoichiometry

In the past few decades, many non-flooding uplands (NF) and permanent flooding waters (PF) have been turned into seasonal flooding wetlands (SF) at the global scale. This trend could severely threaten global climate system by changing carbon cycling in terrestrial and aquatic ecosystems. However, the effects of SF expansion on soil and sediment organic carbon (SOC) storage and carbon-nutrient stoichiometry are far from clearly understood. Therefore, we explored SOC storage and carbon-nutrient stoichiometry among adjacent NF, SF and PF using 817 samples at 0–100 cm depth increment at Poyang Lake and Shengjin Lake in the middle-lower Yangtze River floodplain, China. The SFs of the two lakes were both Carex lakeshore wetlands. The NF of Shengjin Lake was a near-natural forest, while the NF of Poyang Lake was a disturbed grassland. The results showed that SOC storage at SFs of Poyang Lake and Shengjin Lake was 75.61 and 98.01 Mg C/ha at 0–100 cm depth increment. The difference in SOC storage among nearby NF, SF and PF depended on depth and disturbance. SOC storage at SF was equivalent to that at near-natural NF, but was much higher than that at disturbed NF. SOC storage at SF was 12.62%–24.50% higher than that at PF at 0–30 cm depth increment, but was 15.16%–25.87% lower than that at PF at 0–100 cm depth increment. Edaphic carbon and nutrients followed allometric relationships at most sites and C increased faster than N and P along the depth gradients. Carbon-nutrient stoichiometric relationships at SF and PF were similar, and were more coupled than those at near-natural NF. This research illustrates the strong effects of seasonal flooding on SOC sequestration in terrestrial and aquatic ecosystems, and expands our understanding of carbon cycling in these two ecosystems