102 research outputs found

    Design and modeling of electrolyte pumping power reduction in redox flow cells

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    Because of flexible design, long life, and low-cost maintenance, redox flow cell has been recognized as one of the reliable energy storage techniques in remote power systems. In redox flow cells, electrolyte circulation through carbon felt is necessary in order to produce effective ion exchange during the charge and discharge operations. Pumping power required for electrolyte circulation could be significant, especially for multi-stack cell, due to low permeability of the porous carbon felt. Moreover, effective method for transporting bubbles formed inside the electrode is necessary for increasing the effective area of reaction of the electrodes. To further improve the overall performance of the redox flow cells, we proposed several novel designs of electrolyte inlet/outlet port and flow passage in carbon felt intending to reduce the electrolyte pumping power and to increase the effective area. Based on our numerical modeling, it is found that pumping power can be reduced by appropriate inlet/outlet port design and carbon felt with flow channel. The non-uniform flow pattern may cause the bubbles to be carried away from the electrodes effectively. The proposed designs can be applied not only for the single-stack cell but also applicable for the multiple-stacked cells

    Role of Intergranular Films in Toughened Ceramics

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    The trans-ancestral genomic architecture of glycemic traits

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    Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap
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