593 research outputs found
A Study on the Effect of Design Factors of Slim Keyboard's Tactile Feedback
With the rapid development of computer technology,
the design of computers and keyboards moves towards a trend of
slimness. The change of mobile input devices directly influences
users' behavior. Although multi-touch applications allow entering
texts through a virtual keyboard, the performance, feedback, and
comfortableness of the technology is inferior to traditional keyboard,
and while manufacturers launch mobile touch keyboards and
projection keyboards, the performance has not been satisfying.
Therefore, this study discussed the design factors of slim
pressure-sensitive keyboards. The factors were evaluated with an
objective (accuracy and speed) and a subjective evaluation
(operability, recognition, feedback, and difficulty) depending on the
shape (circle, rectangle, and L-shaped), thickness (flat, 3mm, and
6mm), and force (35±10g, 60±10g, and 85±10g) of the keyboard.
Moreover, MANOVA and Taguchi methods (regarding
signal-to-noise ratios) were conducted to find the optimal level of each
design factor. The research participants, by their typing speed (30
words/ minute), were divided in two groups. Considering the
multitude of variables and levels, the experiments were implemented
using the fractional factorial design. A representative model of the
research samples were established for input task testing. The findings
of this study showed that participants with low typing speed primarily
relied on vision to recognize the keys, and those with high typing
speed relied on tactile feedback that was affected by the thickness and
force of the keys. In the objective and subjective evaluation, a
combination of keyboard design factors that might result in higher
performance and satisfaction was identified (L-shaped, 3mm, and
60±10g) as the optimal combination. The learning curve was analyzed
to make a comparison with a traditional standard keyboard to
investigate the influence of user experience on keyboard operation.
The research results indicated the optimal combination provided input
performance to inferior to a standard keyboard. The results could serve
as a reference for the development of related products in industry and
for applying comprehensively to touch devices and input interfaces
which are interacted with people
A Study on the Effect of Design Factors of Slim Keyboard's Tactile Feedback
With the rapid development of computer technology,
the design of computers and keyboards moves towards a trend of
slimness. The change of mobile input devices directly influences
users' behavior. Although multi-touch applications allow entering
texts through a virtual keyboard, the performance, feedback, and
comfortableness of the technology is inferior to traditional keyboard,
and while manufacturers launch mobile touch keyboards and
projection keyboards, the performance has not been satisfying.
Therefore, this study discussed the design factors of slim
pressure-sensitive keyboards. The factors were evaluated with an
objective (accuracy and speed) and a subjective evaluation
(operability, recognition, feedback, and difficulty) depending on the
shape (circle, rectangle, and L-shaped), thickness (flat, 3mm, and
6mm), and force (35±10g, 60±10g, and 85±10g) of the keyboard.
Moreover, MANOVA and Taguchi methods (regarding
signal-to-noise ratios) were conducted to find the optimal level of each
design factor. The research participants, by their typing speed (30
words/ minute), were divided in two groups. Considering the
multitude of variables and levels, the experiments were implemented
using the fractional factorial design. A representative model of the
research samples were established for input task testing. The findings
of this study showed that participants with low typing speed primarily
relied on vision to recognize the keys, and those with high typing
speed relied on tactile feedback that was affected by the thickness and
force of the keys. In the objective and subjective evaluation, a
combination of keyboard design factors that might result in higher
performance and satisfaction was identified (L-shaped, 3mm, and
60±10g) as the optimal combination. The learning curve was analyzed
to make a comparison with a traditional standard keyboard to
investigate the influence of user experience on keyboard operation.
The research results indicated the optimal combination provided input
performance to inferior to a standard keyboard. The results could serve
as a reference for the development of related products in industry and
for applying comprehensively to touch devices and input interfaces
which are interacted with people
Dermoscopic characterization and image study of a Sister Mary Joseph nodule in a patient with esophageal cancer
AbstractA Sister Mary Joseph nodule (SMJN) is rare cutaneous metastasis spreading to the umbilicus. It originates mostly from an intra-abdominal or pelvic malignancy and is an ominous sign. In this paper, we report a case of a SMJN in a 64-year-old man with esophageal cancer. We recorded his clinical progression, radiologic and nuclear scintigraphic images, and histopathologic and dermoscopic findings. The image study provided information on the localization of the SMJN and dermoscopy showed a polymorphous vascular pattern. The patient received palliative therapy because of terminal disease
Emotion and Concentration Integrated System: Applied to the Detection and Analysis of Consumer Preference
With the expansion of consumer market, the appearance becomes an important issue when consumers make decisions under the situation of similar qualities and contents. Accordingly, to attract consumers, companies cost and take much attention on product appearance. Compared to using questionnaires individually, obtaining humansâ thoughts directly from their brains can accurately grasp the actual preference of consumers, which can provide effective and precious decisions for companies. \ In this study, consumersâ brainwaves which are related to concentration and emotion are extracted by wearing a portable and wireless Electroencephalography (EEG) device. The extracted EEG data are then trained by using perceptron learning algorithm (PLA) to make the judgments of concentration and emotion work well with each subject. They are then applied to the detection and analysis of consumer preference. Finally, the questionnaires are also performed and used as the reference on training process. They are integrated with brainwaves data to create one prediction model which can improve the accuracy significantly. The Partial Least Squares is used to compare the correlation between different factors in the model, to ensure the test can accurately meet consumersâ thoughts
All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation
All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells. It has been indicated that cyclin-dependent kinase 5 (Cdk5) activity can be affected by ATRA treatment. Our previous results demonstrate the involvement of Cdk5 in the fate of prostate cancer cells. The purpose of this study is to examine whether Cdk5 is involved in ATRA-induced growth arrest of the castration-resistant cancer cell line DU145 through up-regulating Cdk inhibitor protein, p27
Genetic and Functional Analysis of the DLG4 Gene Encoding the Post-Synaptic Density Protein 95 in Schizophrenia
Hypofunction of N-methyl-D-aspartate (NMDA) receptor-mediated signal transduction has been implicated in the pathophysiology of schizophrenia. Post-synaptic density protein 95 (PSD95) plays a critical role in regulating the trafficking and activity of the NMDA receptor and altered expression of the PSD95 has been detected in the post-mortem brain of patients with schizophrenia. The study aimed to examine whether the DLG4 gene that encodes the PSD95 may confer genetic susceptibility to schizophrenia. We re-sequenced the core promoter, all the exons, and 3âČ untranslated regions (UTR) of the DLG4 gene in 588 Taiwanese schizophrenic patients and conducted an association study with 539 non-psychotic subjects. We did not detect any rare mutations at the protein-coding sequences of the DLG4 gene associated with schizophrenia. Nevertheless, we identified four polymorphic markers at the core promoter and 5âČ UTR and one single nucleotide polymorphism (SNP) at the 3âČUTR of the DLG4 gene in this sample. Genetic analysis showed an association of a haplotype (CâD) derived from 2 polymorphic markers at the core promoter (odds ratioâ=â1.26, 95% confidence intervalâ=â1.06â1.51, pâ=â0.01), and a borderline association of the T allele of the rs13331 at 3âČUTR with schizophrenia (odds ratioâ=â1.19, 95% confidence intervalâ=â0.99â1.43, pâ=â0.06). Further reporter gene assay showed that the C-D-C-C and the T allele of the rs13331 had significant lower activity than their counter parts. Our data indicate that the expression of the DLG4 gene is subject to regulation by the polymorphic markers at the core promoter region, 5âČ and 3âČUTR of the gene, and is associated with the susceptibility of schizophrenia
- âŠ