107 research outputs found
Transient overshoot extensional rheology of long-chain branched polyethylenes: Experimental and numerical comparisons between filament stretching and cross-slot flow
This work analyses the high-strain extensional behavior of long-chain branched polyethylenes, employing two novel extensional rheometer devices, the filament stretching rheometer and the cross-slot extensional rheometer. The filament stretching rheometer uses an active feedback loop to control the imposed strain rate on a filament, allowing Hencky strains of around 7 to be reached. The cross-slot extensional rheometer uses optical birefringence patterns to determine the steady-state extensional viscosity from planar stagnation point flow. The two methods probe different strain-rate regimes and in this paper we demonstrate the agreement when the operating regimes overlap and explore the steady-state extensional viscosity in the full strain-rate regime that these two complimentary techniques offer. For long-chain branched materials, the cross-slot birefringence images show a double cusp pattern around the outflow centre line (named W-cusps). Using constitutive modeling of the observed transient overshoot in extension seen in the filament stretching rheometer and using finite element simulations we show that the overshoot explains the W-cusps seen in the cross-slot extensional rheometer, further confirming the agreement between the two experimental techniques. © 2013 The Society of Rheology
Habitable Zones of Host Stars During the Post-MS Phase
A star will become brighter and brighter with stellar evolution, and the
distance of its habitable zone will become farther and farther. Some planets
outside the habitable zone of a host star during the main sequence phase may
enter the habitable zone of the host star during other evolutionary phases. A
terrestrial planet within the habitable zone of its host star is generally
thought to be suited to life existence. Furthermore, a rocky moon around a
giant planet may be also suited to life survive, provided that the planet-moon
system is within the habitable zone of its host star. Using Eggleton's code and
the boundary flux of habitable zone, we calculate the habitable zone of our
Solar after the main sequence phase. It is found that Mars' orbit and Jupiter's
orbit will enter the habitable zone of Solar during the subgiant branch phase
and the red giant branch phase, respectively. And the orbit of Saturn will
enter the habitable zone of Solar during the He-burning phase for about 137
million years. Life is unlikely at any time on Saturn, as it is a giant gaseous
planet. However, Titan, the rocky moon of Saturn, may be suitable for
biological evolution and become another Earth during that time. For low-mass
stars, there are similar habitable zones during the He-burning phase as our
Solar, because there are similar core masses and luminosities for these stars
during that phase.Comment: 6 pages, 7 figures. Accepted by Ap & S
See-Saw Modification of Gravity
We discuss a model in which the fundamental scale of gravity is restricted to
10^{-3} eV. An observable modification of gravity occurs simultaneously at the
Hubble distance and at around 0.1 mm. These predictions can be tested both by
the table-top experiments and by cosmological measurements. The model is
formulated as a brane-world theory embedded in a space with two or more
infinite-volume extra dimensions. Gravity on the brane reproduces the
four-dimensional laws at observable distances but turns to the high-dimensional
behavior at larger scales. To determine the crossover distance we smooth out
the singularities in the Green's functions by taking into account softening of
the graviton propagator due to the high-dimensional operators that are
suppressed by the fundamental scale. We find that irrespective of the precise
nature of microscopic gravity the ultraviolet and infrared scales of
gravity-modification are rigidly correlated. This fixes the fundamental scale
of gravity at 10^{-3} eV. The result persists for nonzero thickness branes.Comment: 24 LaTex pages; v2: comments added, typos correcte
Habitable Zones and UV Habitable Zones around Host Stars
Ultraviolet radiation is a double-edged sword to life. If it is too strong,
the terrestrial biological systems will be damaged. And if it is too weak, the
synthesis of many biochemical compounds can not go along. We try to obtain the
continuous ultraviolet habitable zones, and compare the ultraviolet habitable
zones with the habitable zones of host stars. Using the boundary ultraviolet
radiation of ultraviolet habitable zone, we calculate the ultraviolet habitable
zones of host stars with masses from 0.08 to 4.00 \mo. For the host stars with
effective temperatures lower than 4,600 K, the ultraviolet habitable zones are
closer than the habitable zones. For the host stars with effective temperatures
higher than 7,137 K, the ultraviolet habitable zones are farther than the
habitable zones. For hot subdwarf as a host star, the distance of the
ultraviolet habitable zone is about ten times more than that of the habitable
zone, which is not suitable for life existence.Comment: 5 pages, 3 figure
Professionalism, Golf Coaching and a Master of Science Degree: A commentary
As a point of reference I congratulate Simon Jenkins on tackling the issue of professionalism in coaching. As he points out coaching is not a profession, but this does not mean that coaching would not benefit from going through a professionalization process. As things stand I find that the stimulus article unpacks some critically important issues of professionalism, broadly within the context of golf coaching. However, I am not sure enough is made of understanding what professional (golf) coaching actually is nor how the development of a professional golf coach can be facilitated by a Master of Science Degree (M.Sc.). I will focus my commentary on these two issues
The prognostic significance of low-frequency somatic mutations in metastatic cutaneous melanoma
Background: Little is known about the prognostic significance of somatically mutated genes in metastatic melanoma (MM). We have employed a combined clinical and bioinformatics approach on tumor samples from cutaneous melanoma (SKCM) as part of The Cancer Genome Atlas project (TCGA) to identify mutated genes with potential clinical relevance. Methods: After limiting our DNA sequencing analysis to MM samples (n = 356) and to the CANCER CENSUS gene list, we filtered out mutations with low functional significance (snpEFF). We performed Cox analysis on 53 genes that were mutated in ≥3% of samples, and had ≥50% difference in incidence of mutations in deceased subjects versus alive subjects. Results: Four genes were potentially prognostic [RAC1, FGFR1, CARD11, CIITA; false discovery rate (FDR) 75% of the samples that exhibited corresponding DNA mutations. The low frequency, UV signature type and RNA expression of the 22 genes in MM samples were confirmed in a separate multi-institution validation cohort (n = 413). An underpowered analysis within a subset of this validation cohort with available patient follow-up (n = 224) showed that somatic mutations in SPEN and RAC1 reached borderline prognostic significance [log-rank favorable (p = 0.09) and adverse (p = 0.07), respectively]. Somatic mutations in SPEN, and to a lesser extent RAC1, were not associated with definite gene copy number or RNA expression alterations. High (>2+) nuclear plus cytoplasmic expression intensity for SPEN was associated with longer melanoma-specific overall survival (OS) compared to lower (≤ 2+) nuclear intensity (p = 0.048). We conclude that expressed somatic mutations in infrequently mutated genes beyond the well-characterized ones (e.g., BRAF, RAS, CDKN2A, PTEN, TP53), such as RAC1 and SPEN, may have prognostic significance in MM
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Black Holes at the LHC
In these two lectures, we will address the topic of the creation of small
black holes during particle collisions in a ground-based accelerator, such as
LHC, in the context of a higher-dimensional theory. We will cover the main
assumptions, criteria and estimates for their creation, and we will discuss
their properties after their formation. The most important observable effect
associated with their creation is likely to be the emission of Hawking
radiation during their evaporation process. After presenting the mathematical
formalism for its study, we will review the current results for the emission of
particles both on the brane and in the bulk. We will finish with a discussion
of the methodology that will be used to study these spectra, and the observable
signatures that will help us identify the black-hole events.Comment: 37 pages, 14 figures, lectures presented in the 4th Aegean Summer
School on Black Holes, 17-22 September 2007, Lesvos, Greece, typos corrected,
comments and references adde
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