Analogues of Nitrofuran Antibiotics are Potent GroEL/ES Pro-drug Inhibitors with Efficacy against Enterococcus Faecium, Staphylococcus Aureus, and Escherichia Coli

Indiana University-Purdue University Indianapolis (IUPUI

Spirituality: It’s a Matter of the Heart

The school leader’s spirituality flows from and is ever rooted in the heart; that is to say, in principles which are molded in one of the great traditions of the faith. In this article characteristics of gospel spirituality are described and the author incorporates practical examples of how this spirituality is lived within his school

Minimisation of energy consumption variance for multi-process manufacturing lines through genetic algorithm manipulation of production schedule

Typical manufacturing scheduling algorithms do not consider the energy consumption of each job, or its variance, when they generate a production schedule. This can become problematic for manufacturers when local infrastructure has limited energy distribution capabilities. In this paper, a genetic algorithm based schedule modification algorithm is presented. By referencing energy consumption models for each job, adjustments are made to the original schedule so that it produces a minimal variance in the total energy consumption in a multi-process manufacturing production line, all while operating within the constraints of the manufacturing line and individual processes. Empirical results show a significant reduction in energy consumption variance can be achieved on schedules containing multiple concurrent jobs

Integration of plastids with their hosts: Lessons learned from dinoflagellates.

After their endosymbiotic acquisition, plastids become intimately connected with the biology of their host. For example, genes essential for plastid function may be relocated from the genomes of plastids to the host nucleus, and pathways may evolve within the host to support the plastid. In this review, we consider the different degrees of integration observed in dinoflagellates and their associated plastids, which have been acquired through multiple different endosymbiotic events. Most dinoflagellate species possess plastids that contain the pigment peridinin and show extreme reduction and integration with the host biology. In some species, these plastids have been replaced through serial endosymbiosis with plastids derived from a different phylogenetic derivation, of which some have become intimately connected with the biology of the host whereas others have not. We discuss in particular the evolution of the fucoxanthin-containing dinoflagellates, which have adapted pathways retained from the ancestral peridinin plastid symbiosis for transcript processing in their current, serially acquired plastids. Finally, we consider why such a diversity of different degrees of integration between host and plastid is observed in different dinoflagellates and how dinoflagellates may thus inform our broader understanding of plastid evolution and function.This is the author accepted manuscript. The final version is available from PNAS via http://dx.doi.org/10.1073/pnas.142138011

Ombres, illusions et réalités dans l’histoire de la Mandchourie moderne

Lecture critique de : Manchuria under Japanese Dominationde Yamamuro Shin’ichi, traduit par Joshua A. Fogel, University of Pennsylvania Press, 2006

The Gauged (2,1) Heterotic Sigma-Model

The geometry of (2,1) supersymmetric sigma-models with isometry symmetries is discussed. The gauging of such symmetries in superspace is then studied. We find that the coupling to the (2,1) Yang-Mills supermultiplet can be achieved provided certain geometric conditions are satisfied. We construct the general gauged action, using an auxiliary vector to generate the full non-polynomial structure.Comment: LaTeX, 25 pages, no figures; version to appear in Nuclear Physics