186 research outputs found
Highly coloured and electrophoretically active polymer microparticles via staggered dispersion polymerisation in supercritical carbon dioxide and dodecane
Devices featuring electrophoretic displays (EPD) have become extremely popular in recent years because of their low power consumption, high readability and thin display designs, but a product with a full colour gamut comparable with liquid crystal displays (LCDs) has not yet been commercialised. In this article, we demonstrate that staggering the addition of methyl methacrylate (MMA) monomer and low quantities of a coloured dye crosslinker is an effective route to producing well-defined and covalently-linked, strongly coloured PMMA microparticles in one-pot, via dispersion polymerisation in supercritical carbon dioxide (scCO2). This novel methodology is synthetically simple, readily scalable and has the added cachet of being cost effective because the functional molecules can be confined on the microparticle surface such that even at low concentrations, the resulting materials are brightly coloured. We then demonstrate the applicability of this approach to another functional comonomer/crosslinker system in 2-dimethylaminoethyl methacrylate (DMAEMA)/ethyleneglycol dimethacrylate (EGDMA), in this case allowing hierarchically structured ‘pomegranate-like’ microparticles with polarisable charge to be produced over a range of DMAEMA loadings as high as 44 wt%. Finally, the performance of these materials in out-of-plane EPD test cells is compared against analogues synthesised in dodecane. These tests revealed that the coloured microparticles fabricated in scCO2 performed as well as or better than their dodecane synthesised counterparts, consistently producing the cleanest white state and achieving effective colour switching over ten cycles
The use of shift reagents in ion mobility-mass spectrometry: studies on the complexation of an active pharmaceutical ingredient with polyethylene glycol excipients
Gas-phase ion mobility studies of mixtures containing polyethylene glycols (PEG) and an active pharmaceutical ingredient (API), Lamivudine, have been carried out using electrospray ionization-ion mobility spectrometry-quadrupole-time-of-flight mass spectrometry (ESI-IMS-Q-TOF). In addition to protonated and cationised PEG oligomers, a series of high molecular weight ions were observed and identified as non-covalent complexes formed between Lamivudine and PEG oligomers. The non-covalent complex ions were dissociated using collision induced dissociation (CID) after separation in the ion mobility drift tube to recover the protonated Lamivudine free from interfering matrix ions and with a drift time associated with the precursor complex. The potential of PEG excipients to act as ‘shift reagents’, which enhance selectivity by moving the mass/mobility locus to an area of the spectrum away from interferences, is demonstrated for the analysis of Lamivudine in a Combivir formulation containing PEG and Lamivudine
Photoproduction of pi0-mesons off neutrons in the nucleon resonance region
Precise angular distributions have been measured for the first time for the
photoproduction of -mesons off neutrons bound in the deuteron. The
effects from nuclear Fermi motion have been eliminated by a complete kinematic
reconstruction of the final state. The influence of final-state-interaction
effects has been estimated by a comparison of the reaction cross section for
quasi-free protons bound in the deuteron to the results for free protons and
then applied as a correction to the quasi-free neutron data. The experiment was
performed at the tagged photon facility of the Mainz Microtron MAMI with the
Crystal Ball and TAPS detector setup for incident photon energies between
~GeV and ~GeV. The results are compared to the predictions from
reaction models and partial-wave analyses based on data from other isospin
channels. The model predictions show large discrepancies among each other and
the present data will provide much tighter constraints. This is demonstrated by
the results of a new analysis in the framework of the Bonn-Gatchina
coupled-channel analysis which included the present data.Comment: accepted for publication in Phys; Rev. Let
Measurement of the transverse target and beam-target asymmetries in meson photoproduction at MAMI
We present new data for the transverse target asymmetry T and the very first
data for the beam-target asymmetry F in the
reaction up to a center-of-mass energy of W=1.9 GeV. The data were obtained
with the Crystal-Ball/TAPS detector setup at the Glasgow tagged photon facility
of the Mainz Microtron MAMI. All existing model predictions fail to reproduce
the new data indicating a significant impact on our understanding of the
underlying dynamics of meson photoproduction. The peculiar nodal
structure observed in existing T data close to threshold is not confirmed.Comment: 5 pages, 3 figures, accepted for publication in PR
Photoproduction of -pairs off protons and off neutrons
Total cross sections, angular distributions, and invariant-mass distributions
have been measured for the photoproduction of pairs off free
protons and off nucleons bound in the deuteron. The experiments were performed
at the MAMI accelerator facility in Mainz using the Glasgow photon tagging
spectrometer and the Crystal Ball/TAPS detector. The accelerator delivered
electron beams of 1508 and 1557~MeV, which produced bremsstrahlung in thin
radiator foils. The tagged photon beam covered energies up to 1400~MeV. The
data from the free proton target are in good agreement with previous
measurements and were only used to test the analysis procedures. The results
for differential cross sections (angular distributions and invariant-mass
distributions) for free and quasi-free protons are almost identical in shape,
but differ in absolute magnitude up to 15\%. Thus, moderate final-state
interaction effects are present. The data for quasi-free neutrons are similar
to the proton data in the second resonance region (final state invariant masses
up to 1550~MeV), where both reactions are dominated by the
decay. At higher energies,
angular and invariant-mass distributions are different. A simple analysis of
the shapes of the invariant-mass distributions in the third resonance region is
consistent with strong contributions of an decay
for the proton, while the reaction is dominated by a sequential decay via a
intermediate state for the neutron. The data are compared to
predictions from the Two-Pion-MAID model and the Bonn-Gatchina coupled channel
analysis.Comment: accepted for publication in Eur. Phys. J.
Quasifree photoproduction of mesons off protons and neutrons
Differential and total cross sections for the quasifree reactions and have been determined at the
MAMI-C electron accelerator using a liquid deuterium target. Photons were
produced via bremsstrahlung from the 1.5 GeV incident electron beam and
energy-tagged with the Glasgow photon tagger. Decay photons of the neutral
decay modes and and coincident recoil nucleons were detected in a combined setup of
the Crystal Ball and the TAPS calorimeters. The -production cross
sections were measured in coincidence with recoil protons, recoil neutrons, and
in an inclusive mode without a condition on recoil nucleons, which allowed a
check of the internal consistency of the data. The effects from nuclear Fermi
motion were removed by a kinematic reconstruction of the final-state invariant
mass and possible nuclear effects on the quasifree cross section were
investigated by a comparison of free and quasifree proton data. The results,
which represent a significant improvement in statistical quality compared to
previous measurements, agree with the known neutron-to-proton cross-section
ratio in the peak of the resonance and confirm a peak in the
neutron cross section, which is absent for the proton, at a center-of-mass
energy MeV with an intrinsic width of MeV
Measurement of the beam-helicity asymmetry in the photoproduction of -pairs off protons and off neutrons
Beam-helicity asymmetries have been measured at the MAMI accelerator in Mainz
for the photoproduction of mixed-charge pion pairs in the reactions
off free protons and
and
off quasi-free nucleons bound
in the deuteron for incident photon energies up to 1.4 GeV. Circularly
polarized photons were produced from bremsstrahlung of longitudinally polarized
electrons and tagged with the Glasgow-Mainz magnetic spectrometer. The charged
pions, recoil protons, recoil neutrons, and decay photons from mesons
were detected in the 4 electromagnetic calorimeter composed of the Crystal
Ball and TAPS detectors. Using a complete kinematic reconstruction of the final
state, excellent agreement was found between the results for free and
quasi-free protons, suggesting that the quasi-free neutron results are also a
close approximation of the free-neutron asymmetries. A comparison of the
results to the predictions of the Two-Pion-MAID reaction model shows that the
reaction mechanisms are still not well understood, in particular at low
incident photon energies in the second nucleon-resonance region.Comment: accepted for publication in Eur. phys. J.
Photoproduction of π0-pairs off protons and off neutrons
Total cross sections, angular distributions, and invariant-mass distributions have been measured for the photoproduction of π0π0 pairs off free protons and off nucleons bound in the deuteron. The experiments were performed at the MAMI accelerator facility in Mainz using the Glasgow photon tagging spectrometer and the Crystal Ball/TAPS detector. The accelerator delivered electron beams of 1508 and 1557MeV, which produced bremsstrahlung in thin radiator foils. The tagged photon beam covered energies up to 1400MeV. The data from the free proton target are in good agreement with previous measurements and were only used to test the analysis procedures. The results for differential cross sections (angular distributions and invariant-mass distributions) for free and quasi-free protons are almost identical in shape, but differ in absolute magnitude up to 15%. Thus, moderate final-state interaction effects are present. The data for quasi-free neutrons are similar to the proton data in the second resonance region (final-state invariant masses up to ≈1550 MeV), where both reactions are dominated by the N(1520)3/2−→Δ(1232)3/2+π decay. At higher energies, angular and invariant-mass distributions are different. A simple analysis of the shapes of the invariant-mass distributions in the third resonance region is consistent with strong contributions of an N⋆→Nσ decay for the proton, while the reaction is dominated by a sequential decay via a Δπ intermediate state for the neutron. The data are compared to predictions from the Two-Pion-MAID model and the Bonn-Gatchina coupled-channel analysis
The isospin structure of photoproduction of pi-eta pairs from the nucleon in the threshold region
Photoproduction of -pairs from nucleons has been investigated from
threshold up to incident photon energies of ~1.4~GeV. The quasi-free
reactions , ,
, and were for
the first time measured from nucleons bound in the deuteron. The corresponding
reactions from a free-proton target were also studied to investigate
final-state interaction effects (for neutral pions the free-proton results
could be compared to previous measurements; the reaction was measured for the first time). For the
final state coherent production via the
reaction was also investigated. The experiments were performed at the tagged
photon beam of the Mainz MAMI accelerator using an almost coverage
electromagnetic calorimeter composed of the Crystal Ball and TAPS detectors.
The total cross sections for the four different final states obey the relation
as expected for a
dominant contribution from a
reaction chain,
which is also supported by the shapes of the invariant-mass distributions of
nucleon-meson and - pairs. The experimental results are compared to
the predictions from an isobar reaction model.Comment: accepted for publication in Phys. Lett.
T and F asymmetries in π0 photoproduction on the proton
The γp→π0p reaction was studied at laboratory photon energies from 425 to 1445 MeV with a transversely polarized target and a longitudinally polarized beam. The beam-target asymmetry F was measured for the first time and new high precision data for the target asymmetry T were obtained. The experiment was performed at the photon tagging facility of the Mainz Microtron (MAMI) using the Crystal Ball and TAPS photon spectrometers. The polarized cross sections were expanded in terms of associated Legendre functions and compared to recent predictions from several partial-wave analyses. The impact of the new data on our understanding of the underlying partial-wave amplitudes and baryon resonance contributions is discussed
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