2,340 research outputs found

    Let’s Talk: An Examination of Parental Involvement as a Predictor of STEM Achievement in Math for High School Girls

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    This research was conducted to examine the influence of parental involvement, in the form of parent conversations, on mathematics achievement for high school girls. Data from the High School Longitudinal Study of 2009 (HSLS:09) public-use file provided a sample of 13,694 students, including 6,592 girls for our analyses. A scale for measuring parent conversations was developed and regression analyses were conducted to examine whether this scale variable predicted mathematics achievement. Results indicated that conversational parental involvement was a significant predictor of mathematics achievement for Black and White girls, but not Hispanic and Asian. Implications for research and policy initiatives are discussed

    CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress

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    The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and tolerance to nitric oxide (NO). Loss of CydDC was found to decrease extracytoplasmic thiol levels, whereas overexpression diminished the cytoplasmic thiol content. Transcriptomic analysis revealed a dramatic up-regulation of protein chaperones, protein degradation (via phenylpropionate/phenylacetate catabolism), ?-oxidation of fatty acids, and genes involved in nitrate/nitrite reduction. 1H NMR metabolomics revealed elevated methionine and betaine and diminished acetate and NAD+ in cydD cells, which was consistent with the transcriptomics-based metabolic model. The growth rate and ?pH, however, were unaffected, although the cydD strain did exhibit sensitivity to the NO-releasing compound NOC-12. These observations are consistent with the hypothesis that the loss of CydDC-mediated reductant export promotes protein misfolding, adaptations to energy metabolism, and sensitivity to NO. The addition of both glutathione and cysteine to the medium was found to complement the loss of bd -type cytochrome synthesis in a cydD strain (a key component of the pleiotropic cydDC phenotype), providing the first direct evidence that CydDC substrates are able to restore the correct assembly of this respiratory oxidase. These data provide an insight into the metabolic flexibility of E. coli , highlight the importance of bacterial redox homeostasis during nitrosative stress, and report for the first time the ability of periplasmic low molecular weight thiols to restore haem incorporation into a cytochrome complex

    Malaria control in humanitarian emergencies: An interagency field handbook, 2nd Edition

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    This second edition represents a thorough updating and revision of the first edition. The structure remains similar, but includes an additional chapter on humanitarian coordination. All chapters have been revised to reflect changes in best practices, improvements in technologies, availability of new tools, and changes in WHO recommendations. The interagency handbook was developed to set out effective malaria control responses in humanitarian emergencies, particularly during the acute phase when reliance on international humanitarian assistance is greatest. It provides policy-makers, planners, and field coordinators with practical advice on designing and implementing measures to reduce malaria morbidity and mortality in both man-made and natural disasters. Such measures must address the needs of all affected population groups and accommodate changing needs as an acute emergency evolves into either recovery or chronic emergency phase. The handbook is organized as follows: Chapter 1: Introduction introduces complex humanitarian emergencies and malaria control. Chapter 2: Coordination describes essential coordination, advocacy and resource mobilization. Chapter 3: Assessment and operational planning describes how to assess malaria burden in an emergency, identify those most at risk, and use the information collected to design an effective response. Chapter 4: Surveillance discusses establishment of disease surveillance systems to monitor the malaria situation. Chapter 5: Outbreaks describes how to prepare for and respond to a sudden increase in malaria cases. Chapter 6: Case management describes methods of diagnosis, treatment, and patient care in humanitarian emergencies. Chapter 7: Prevention describes approaches and tools for vector control and personal malaria protection during emergencies. Chapter 8: Community participation discusses how to mobilize affected communities to improve malaria control interventions. MALARIA CONTROL IN HUMANITARIAN EMERGENCIES viii Chapter 9: Operational research and associated routine monitoring discusses conducting research to improve the effectiveness of prevention and treatment in humanitarian emergencies. A glossary is provided at the beginning of the handbook. Suggestions for further reading are included at the end of several chapters. Ideal, or gold standard, approaches to malaria control are not always feasible in humanitarian emergencies. Interventions must be adapted to the realities of each emergency. Using this handbook should help humanitarian workers implement effective and concerted responses to malaria problems. As new information becomes available, updates to this handbook will be published. Comments and suggestions are welcome and should be sent to WHO/Global Malaria Programme ([email protected])

    Couple-Based HIV Prevention in the United States: Advantages, Gaps, and Future Directions

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    This article presents an overview of couple-based HIV prevention research to date, advantages of using and core components of couple-based interventions, gaps in the current understanding of couple-based HIV prevention, status of dissemination research and the transportability of effective couple-based HIV prevention and treatment to real-world settings, and recommendations for future directions in couple-based prevention and treatment. Couple-based studies conducted among several populations—heterosexuals, men who have sex with men, and drug users—reported in the research literature were reviewed. Commonalities and limitations were noted in customary focus areas of the couple-based approaches: sexual and drug risk reduction, HIV testing behaviors, adherence to HIV treatment, and prevention of mother-to-child transmission. Couple-based intervention strategies have been rigorously tested and are a valuable addition to the arsenal of HIV prevention strategies. Immediate needs and opportunities include couple-based intervention strategies for prevention of HIV and other sexually transmitted infections among serodiscordant couples, couples who do not know their HIV status, and couples in whom both partners are HIV negative, but at risk of HIV infection. There is a particular need to develop couple-based intervention strategies for men who have sex with men and for drug-involved couples
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