335 research outputs found
Ground deformation detection of the greater area of Thessaloniki (Northern Greece) using radar interferometry techniques
In the present study SAR interferometric techniques (stacking of conventional interferograms and Permanent Scatterers), using images from satellites ERS-1 and 2, have been applied to the region of Thessaloniki (northern Greece). The period covered by the images is 1992–2000. Both techniques gave good quantitative and qualitative results. The interferometric products were used to study ground surface deformation phenomena that could be related to the local tectonic context, the exploitation of underground water and sediments compaction. <br><br> The city of Thessaloniki shows relatively stable ground conditions. Subsidence in four locations, mainly in the area surrounding the city of Thessaloniki, has been detected and assessed. Two of the sites (Sindos-Kalochori and Langadhas) were already known from previous studies as subsiding areas, using ground base measurements. On the contrary the other two sites in the northern suburbs of Thessaloniki (Oreokastro) and in the south-east (airport area) were unknown as areas of subsidence. A further investigation based on fieldwork is needed in these two areas. Finally, an attempt to interpret the observed deformation, according to the geological regime of the area and its anthropogenic activities, has been carried out
The study of personality preschool children in modern foreign research
The article deals with the problem of studying and describing the personality of the child in the preschool age. Provides the review of modern foreign studies on this issue. Grounded the importance of age characteristics for describing the structure of the child's personality.В статье рассматривается проблема изучения и описания личности ребенка в дошкольном возрасте. Представлен обзор современных зарубежных исследований, посвященных данному вопросу. Обосновывается важность возрастных характеристик для описания структуры личности ребенка
A Bitter Pill: The Primordial Lithium Problem Worsens
The lithium problem arises from the significant discrepancy between the
primordial 7Li abundance as predicted by BBN theory and the WMAP baryon
density, and the pre-Galactic lithium abundance inferred from observations of
metal-poor (Population II) stars. This problem has loomed for the past decade,
with a persistent discrepancy of a factor of 2--3 in 7Li/H. Recent developments
have sharpened all aspects of the Li problem. Namely: (1) BBN theory
predictions have sharpened due to new nuclear data, particularly the
uncertainty on 3He(alpha,gamma)7Be, has reduced to 7.4%, and with a central
value shift of ~ +0.04 keV barn. (2) The WMAP 5-year data now yields a cosmic
baryon density with an uncertainty reduced to 2.7%. (3) Observations of
metal-poor stars have tested for systematic effects, and have reaped new
lithium isotopic data. With these, we now find that the BBN+WMAP predicts 7Li/H
= (5.24+0.71-0.67) 10^{-10}. The Li problem remains and indeed is exacerbated;
the discrepancy is now a factor 2.4--4.3 or 4.2sigma (from globular cluster
stars) to 5.3sigma (from halo field stars). Possible resolutions to the lithium
problem are briefly reviewed, and key nuclear, particle, and astronomical
measurements highlighted.Comment: 21 pages, 4 figures. Comments welcom
Big Bang Nucleosynthesis and Particle Dark Matter
We review how our current understanding of the light element synthesis during
the Big Bang Nucleosynthesis era may help shed light on the identity of
particle dark matter.Comment: a mini-review for the NJP special issue on dark matte
Exaggerated Texture and Grain Growth in a Supperplastic SiAlON
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65254/1/j.1151-2916.1992.tb05497.x.pd
26S Proteasome Activity Is Down-Regulated in Lung Cancer Stem-Like Cells Propagated In Vitro
Cancer stem cells (CSCs) are a small subset of cancer cells capable of self-renewal and tumor maintenance. Eradicating cancer stem cells, the root of tumor origin and recurrence, has emerged as one promising approach to improve lung cancer survival. Cancer stem cells are reported to reside in the side population (SP) of cultured lung cancer cells. We report here the coexistence of a distinct population of non-SP (NSP) cells that have equivalent self-renewal capacity compared to SP cells in a lung tumor sphere assay. Compared with the corresponding cells in monolayer cultures, lung tumor spheres, formed from human non-small cell lung carcinoma cell lines A549 or H1299, showed marked morphologic differences and increased expression of the stem cell markers CD133 and OCT3/4. Lung tumor spheres also exhibited increased tumorigenic potential as only 10,000 lung tumor sphere cells were required to produce xenografts tumors in nude mice, whereas the same number of monolayer cells failed to induce tumors. We also demonstrate that lung tumor spheres showed decreased 26S proteasome activity compared to monolayer. By using the ZsGreen–cODC (C-terminal sequence that directs degradation of Ornithine Decarboxylase) reporter assay in NSCLC cell lines, only less than 1% monolayer cultures were ZsGreen positive indicating low 26S proteasome, whereas lung tumor sphere showed increased numbers of ZsGreen-positive cells, suggesting the enrichment of CSCs in sphere cultures
Enhanced tonic GABAA inhibition in typical absence epilepsy
The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired GABAergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABAA receptor–dependent ‘tonic’ inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT–1 in the genetic models tested, and GAT–1 is critical in governing seizure genesis. Extrasynaptic GABAA receptors are a requirement for seizures in two of the best characterized models of absence epilepsy, and the selective activation of thalamic extrasynaptic GABAA receptors is sufficient to elicit both electrographic and behavioural correlates of seizures in normal animals. These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic significance, and highlight novel therapeutic targets for the treatment of absence epilepsy.peer-reviewe
Prospective randomized trial of iliohypogastric-ilioinguinal nerve block on post-operative morphine use after inpatient surgery of the female reproductive tract
<p>Abstract</p> <p>Objective</p> <p>To determine the impact of pre-operative and intra-operative ilioinguinal and iliohypogastric nerve block on post-operative analgesic utilization and length of stay (LOS).</p> <p>Methods</p> <p>We conducted a prospective randomized double-blind placebo controlled trial to assess effectiveness of ilioinguinal-iliohypogastric nerve block (IINB) on post-operative morphine consumption in female study patients (<it>n </it>= 60). Patients undergoing laparotomy via Pfannenstiel incision received injection of either 0.5% bupivacaine + 5 mcg/ml epinephrine for IINB (Group I, <it>n </it>= 28) or saline of equivalent volume given to the same site (Group II, <it>n </it>= 32). All injections were placed before the skin incision and after closure of rectus fascia via direct infiltration. Measured outcomes were post-operative morphine consumption (and associated side-effects), visual analogue pain scores, and hospital length of stay (LOS).</p> <p>Results</p> <p>No difference in morphine use was observed between the two groups (47.3 mg in Group I vs. 45.9 mg in Group II; <it>p </it>= 0.85). There was a trend toward lower pain scores after surgery in Group I, but this was not statistically significant. The mean time to initiate oral narcotics was also similar, 23.3 h in Group I and 22.8 h in Group II (<it>p </it>= 0.7). LOS was somewhat shorter in Group I compared to Group II, but this difference was not statistically significant (<it>p </it>= 0.8). Side-effects occurred with similar frequency in both study groups.</p> <p>Conclusion</p> <p>In this population of patients undergoing inpatient surgery of the female reproductive tract, utilization of post-operative narcotics was not significantly influenced by IINB. Pain scores and LOS were also apparently unaffected by IINB, indicating a need for additional properly controlled prospective studies to identify alternative methods to optimize post-surgical pain management and reduce LOS.</p
Evaluation of strain and stress states in the single point incremental forming process
Single point incremental forming (SPIF) is a promising
manufacturing process suitable for small batch production.
Furthermore, the material formability is enhanced in
comparison with the conventional sheet metal forming processes,
resulting from the small plastic zone and the incremental
nature. Nevertheless, the further development of the SPIF
process requires the full understanding of the material deformation
mechanism, which is of great importance for the effective
process optimization. In this study, a comprehensive
finite element model has been developed to analyse the state
of strain and stress in the vicinity of the contact area, where the
plastic deformation increases by means of the forming tool
action. The numerical model is firstly validated with experimental
results from a simple truncated cone of AA7075-O
aluminium alloy, namely, the forming force evolution, the
final thickness and the plastic strain distributions. In order to
evaluate accurately the through-thickness gradients, the blank
is modelled with solid finite elements. The small contact area
between the forming tool and the sheet produces a negative
mean stress under the tool, postponing the ductile fracture
occurrence. On the other hand, the residual stresses in both
circumferential and meridional directions are positive in the
inner skin of the cone and negative in the outer skin. They
arise predominantly along the circumferential direction due to
the geometrical restrictions in this direction.The authors would like to gratefully acknowledge the
financial support from the Portuguese Foundation for Science and Technology
(FCT) under project PTDC/EMS-TEC/1805/2012. The first author is
also grateful to the FCT for the postdoctoral grant SFRH/BPD/101334/2014.info:eu-repo/semantics/publishedVersio
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