FORMULASI DAN EVALUASI VARIASI BASIS GEL AIR PERASAN TEMUAWAK (Curcuma xanthorrhiza R.) SEBAGAI ANTISEPTIK TANGAN

ABSTRACT Temulawak (Curcuma xanthorrhiza R.) is a plant that contains antimicrobial properties of essential oil and curcumin compounds. The purpose of this study was to formulate temulawak juice into gel preparations by varying the HPMC and Carbomer gel bases with each base concentration of 1%, testing the effectiveness of the antiseptic preparations and evaluating the physical preparations of the gel. This study used laboratory experimental methods. temulawak is soaked in aquadest then filtered and centrifuged to obtain temulawak juice and formulated in a gel preparation. Testing the effectiveness as a hand antiseptic using the replica method. The results showed that the temulawak water gel met the physical properties of the gel preparation which included organoleptic test, homogeneity test, pH test, spreadability test, adhesion test, and syneresis test. The percentage of colony decline using the HPMC base was 29.53% and the Carbomer base was 14.74%. This shows that the gel preparation of Temulawak juice cannot reduce the normal flora of the skin so that it does not affect an antiseptic for hands. Key Words : Antiseptic, gel preparations, Curcuma (Curcuma xanthorrhiza R.)  ABSTRAK Temulawak (Curcuma xanthorrhiza R.) merupakan tanaman yang memiliki kandungan senyawa minyak atsiri dan kurkumin yang bersifat antimikroba. Tujuan dari penelitian ini untuk memformulasikan air perasan temulawak menjadi sediaan gel dengan memvariasikan basis gel HPMC dan Karbomer dengan masing-masing konsentrasi basis sebesar 1 %, menguji efektivitas antiseptik sediaan dan mengevaluasi sediaan fisik dari gel tersebut. Penelitian ini menggunakan metode eksperimental laboratorium. Temulawak direndam dengan aquadest kemudian disaring dan disentrifuse untuk mendapatkan air perasan temulawak dan diformulasikan dalam sediaan gel. Pengujian efektivitas sebagai antiseptik tangan menggunakan metode replika. Hasil penelitian menunjukkan bahwa gel air perasan temulawak memenuhi persyaratan sifat fisik sediaan gel yang meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji sineresis. Presentase penurunan koloni menggunakan basis HPMC sebesar 29,53 % dan basis Karbomer sebesar 14,74 %. Hal ini menunjukkan bahwa sediaan gel air perasan temulawak tidak dapat menurunkan jumlah flora normal kulit sehingga tidak memiliki efek sebagai antiseptik tangan.  Kata Kunci : Antiseptik, sediaan gel, Temulawak (Curcuma xanthorrhiza R.

Pembuatan Game RPG Multiplayer Online Berbasis Android

Gadget is important now, children of all ages already understand how to use gadgets. This resulted in more children often spend time playing the current gadget. By providing entertainment through games application, so users can be entertained. The application consists of 5 menu that map, shop, inventory, character, and tournaments. On the menu map players can carry out the mission and receive a gift. In the shop menu, players can view and purchase goods. On the inventory menu, players can see the items that are owned and can sell it. On the menu character, players can replace equip and improve skills. On the menu tournament, players can challenge other players to be matched with a character of its own. Overall, the application is able to create and display the mission, as well as be able to give levels to players with a rating. Players can also increase the ability of the characters to wear equip and improve skills

A song and dance: branded entertainment and mobile promotion

This article considers the rise of branded entertainment within the contemporary marketing and media environment. Specifically, it examines how mobile phone marketing in the UK has sought to engage consumers and perform the social use of mobile technology through multimedia ad campaigns with an inscribed entertainment value. Focusing on brand campaigns for 3G mobile services that borrow explicitly from reality television (T-Mobile) and Hollywood film (Orange), the article explores the concept of branded entertainment in relation to the ‘popular imagination’ of mobile communication in the late 2000s. In doing so, it examines the particular relation of flash mobs to the production of brand community

Upgrades to the 4-strap ICRF Antenna in Alcator C-Mod

A 4-strap ICRF antenna suitable for plasma heating and current drive has been designed and fabricated for the Alcator C-Mod tokamak. Initial operation in plasma was limited by high metallic impurity injection resulting from front surface arcing between protection tiles and from current straps to Faraday shields. Antenna modifications were made in February 2000, resulting in impurity reduction, but low-heating efficiency was observed when the antenna was operated in its 4-strap rather than a 2-strap configuration. Further modifications were made in July 2000, with the installation of BN plasma-facing tiles and radio- frequency bypassing of the antenna backplane edges and ends to reduce potential leakage coupling to plasma surface modes. Good heating efficiency was now observed in both heating configurations, but coupled power was limited to 2.5 MW in H-mode, 3 MW in L-mode, by plasma-wall interactions. Additional modifications were started in February 2001 and will be completed by this meeting. All the above upgrades and their effect on antenna performance will be presented

Microscopic electroabsorption line shape analysis for Ga(AsSb)∕GaAs heterostructures

A series of Ga(AsSb)/GaAs/(AlGa) As samples with varying GaAs spacer width are studied by electric-field modulated absorption (EA) and reflectance spectroscopy and modeled using a microscopic theory. The analysis of the Franz-Keldysh oscillations of GaAs capping layer and of the quantum-confined Stark shift of the lowest quantum well (QW) transitions shows the strong inhomogeneity of the built-in electric field indicating that the field modulation due to an external bias voltage differs significantly for the various regions of the structures. The calculations demonstrate that the line shape of the EA spectra of these samples is extremely sensitive to the value of the small conduction band offset between GaAs and Ga(AsSb) as well as to the magnitude of the internal electric field changes caused by the external voltage modulation in the QW region. The EA spectra of the entire series of samples are modeled by the microscopic theory. The good agreement between experiment and theory allows us to extract the strength of the modulation of the built-in electric field in the QW region and to show that the band alignment between GaAs and Ga(AsSb) is of type II with a conduction band offset of approximately 40 meV.</p

Effect of plasma shaping on performance in the National Spherical Torus Experiment

The National Spherical Torus Experiment (NSTX) has explored the effects of shaping on plasma performance as determined by many diverse topics including the stability of global magnetohydrodynamic (MHD) modes (e.g., ideal external kinks and resistive wall modes), edge localized modes (ELMs), bootstrap current drive, divertor flux expansion, and heat transport. Improved shaping capability has been crucial to achieving Βt ∼40%. Precise plasma shape control has been achieved on NSTX using real-time equilibrium reconstruction. NSTX has simultaneously achieved elongation κ∼2.8 and triangularity δ∼0.8. Ideal MHD theory predicts increased stability at high values of shaping factor S≡ q95 Ip (a Bt), which has been observed at large values of the S∼37 [MA (m·T)] on NSTX. The behavior of ELMs is observed to depend on plasma shape. A description of the ELM regimes attained as shape is varied will be presented. Increased shaping is predicted to increase the bootstrap fraction at fixed Ip. The achievement of strong shaping has enabled operation with 1 s pulses with Ip =1 MA, and for 1.6 s for Ip =700 kA. Analysis of the noninductive current fraction as well as empirical analysis of the achievable plasma pulse length as elongation is varied will be presented. Data are presented showing a reduction in peak divertor heat load due to increasing in flux expansion. © 2006 American Institute of Physics

Experimental approaches to evaluate activities of cytochromes P450 3A

Cytochrome P450 (CYP) is a heme protein oxidizing various xenobiotics, as well as endogenous substrates. Understanding which CYP enzymes are involved in metabolic activation and/or detoxication of different compounds is important in the assessment of an individual's susceptibility to the toxic action of these substances. Therefore, investigation which of several in vitro experimental models are appropriate to mimic metabolism of xenobiotics in organisms is the major challenge for research of many laboratories. The aim of this study was to evaluate the efficiency of different in vitro systems containing individual enzymes of the mixed-function monooxygenase system to oxidize two model substrates of CYP3A enzymes, exogenous and endogenous compounds, α-naphtoflavone (α-NF) and testosterone, respectively. Several different enzymatic systems containing CYP3A enzymes were utilized in the study: (i) human hepatic microsomes rich in CYP3A4, (ii) hepatic microsomes of rabbits treated with a CYP3A6 inducer, rifampicine, (iii) microsomes of Baculovirus transfected insect cells containing recombinant human CYP3A4 and NADPH:CYP reductase with or without cytochrome b5 (Supersomes™), (iv) membranes isolated from of Escherichia coli, containing recombinant human CYP3A4 and cytochrome b5, and (v) purified human CYP3A4 or rabbit CYP3A6 reconstituted with NADPH:CYP reductase with or without cytochrome b5 in liposomes. The most efficient systems oxidizing both compounds were Supersomes™ containing human CYP3A4 and cytochrome b5. The results presented in this study demonstrate the suitability of the supersomal CYP3A4 systems for studies investigating oxidation of testosterone and α-NF in vitro