#Nationalism: the ethno-nationalist populism of Donald Trump’s Twitter communication

In this article, we explore the ethno-nationalist populism of Donald Trump’s Twitter communication during the 2016 presidential campaign. We draw on insights from ethno-symbolism – a perspective within nationalism studies – to analyse all 5,515 tweets sent by Trump during the campaign. We find that ethno-nationalist and populist themes were by far the most important component of Trump’s tweets, and that these themes built upon long-standing myths and symbols of an ethnic conception of American identity. In sum, Trump’s tweets depicted a virtuous white majority being threatened by several groups of immoral outsiders, who were identified by their foreignness, their religion, and their self-interestedness. The struggle against these groups was framed as a mission to restore America to a mythical golden age – to “Make America Great Again.

The Myxococcus xanthus Two-Component System CorSR Regulates Expression of a Gene Cluster Involved in Maintaining Copper Tolerance during Growth and Development

Myxococcus xanthus is a soil-dwelling member of the δ–Proteobacteria that exhibits a complex developmental cycle upon starvation. Development comprises aggregation and differentiation into environmentally resistant myxospores in an environment that includes fluctuations in metal ion concentrations. While copper is essential for M. xanthus cells because several housekeeping enzymes use it as a cofactor, high copper concentrations are toxic. These opposing effects force cells to maintain a tight copper homeostasis. A plethora of paralogous genes involved in copper detoxification, all of which are differentially regulated, have been reported in M. xanthus. The use of in-frame deletion mutants and fusions with the reporter gene lacZ has allowed the identification of a two-component system, CorSR, that modulates the expression of an operon termed curA consisting of nine genes whose expression slowly increases after metal addition, reaching a plateau. Transcriptional regulation of this operon is complex because transcription can be initiated at different promoters and by different types of regulators. These genes confer copper tolerance during growth and development. Copper induces carotenoid production in a ΔcorSR mutant at lower concentrations than with the wild-type strain due to lack of expression of a gene product resembling subunit III of cbb3-type cytochrome c oxidase. This data may explain why copper induces carotenoid biosynthesis at suboptimal rather than optimal growth conditions in wild-type strains.This work has been funded by the Spanish Government (grants CSD2009-00006 and BFU2012-33248, 70% funded by FEDER). This work was also supported by the National Institute of General Medical Science of the National Institutes of Health under award number R01GM095826 to LJS, and by the National Science Foundation under award number MCB0742976 to LJS. JMD and JP received a fellowship from Junta de Andalucía to do some work at University of Georgia

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis

The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence

OBJECTIVE: To estimate the effect of change in weight and change in urinary incontinence (UI) frequency on changes in preference-based measures of health-related quality of life (HRQL) among overweight and obese women with UI participating in a weight loss trial. METHODS: We conducted a longitudinal cohort analysis of 338 overweight and obese women with UI enrolled in a randomized clinical trial comparing a behavioral weight loss intervention to an educational control condition. At baseline, 6, and 18 months, health utilities were estimated using the Health Utilities Index Mark 3 (HUI3), a transformation of the SF-36 to the preference-based SF-6D, and the estimated Quality of Well-Being (eQWB) score (a summary calculated from the SF-36 physical functioning, mental health, bodily pain, general health perceptions, and role limitations-physical subscale scores). Potential predictors of changes in these outcomes were examined using generalized estimating equations. RESULTS: In adjusted multivariable models, weight loss was associated with improvement in HUI3, SF-6D, and eQWB at 6 and 18 months (P \u3c 0.05). Increases in physical activity also were independently associated with improvement in HUI3 (P = 0.01) and SF-6D (P = 0.006) scores at 18 months. In contrast, reduction in UI frequency did not predict improvements in HRQL at 6 or 18 months. CONCLUSION: Weight loss and increased physical activity, but not reduction in UI frequency, were strongly associated with improvements in health utilities measured by the HUI3, SF-6D, and eQWB. These findings provide important information that can be used to inform cost-utility analyses of weight loss interventions

Water conservation options for Fajardo, Puerto Rico

The goal for this project, done in conjunction with the U.S. Geological Survey, Caribbean District, was to discover water use trends and consumer water conservation attitudes in order to recommend water conservation strategies for the municipality of Fajardo, Puerto Rico. We analyzed water use and conservation practices of domestic, commercial, industrial and institutional water user samples, based on socio-economic level and location in the water distribution system. Based on our results, we then presented four possible strategic water conservation plans for Fajardo

Sheet-like emplacement of satellite laccoliths, sills, and bysmaliths of the Henry Mountains, Southern Utah

International audienceSmall intrusions (<3 km 2) on the margins of the Henry Mountains intrusive complex of southern Utah are exceptionally well exposed in three dimensions and have a variety of shapes. Our examination of the geometry, structures, and fabric of the Maiden Creek sill, Trachyte Mesa laccolith, and the Black Mesa bysmalith (cylindrical intrusion bounded by vertical faults) suggests that this range of intrusion geometry may refl ect a continuum of igneous emplacement as volume increases through magma sheeting. Intrusions begin as thin sills and through incremental injection of additional sheets, infl ate into laccoliths. Marginal wall rocks are strained and rotated upward. Further sheet emplacement leads to the formation of a fault at the margin of the infl ating intrusion. This fault accommodates piston-like uplift of the intrusion's roof and results in the formation of a bysmalith. All three of these intrusions exhibit evidence for sheeting, although the evidence is weakest on the margins of the Black Mesa bysmalith. Solid-state shear zones exist between sheets in the Maiden Creek sill and on the margins of the Trachyte Mesa laccolith. Cataclastic zones also separate sheets within the Trachyte Mesa laccolith. Evidence for sheeting in the interior of the Trachyte Mesa laccolith is solely based on differences in weathering and jointing patterns. Evidence for sheeting on the margins of the Black Mesa bysmalith is based on the differences in lineation patterns and also on the distribution of cataclastic zones

Emplacement of multiple magma sheets and wall rock deformation: Trachyte Mesa intrusion, Henry Mountains, Utah

International audienceA detailed structural and rock magnetic study of the Trachyte Mesa intrusion and deformed sedimentary wall rocks, Henry Mountains, Utah, indicates that the intrusion grew vertically and horizontally by the accumulation of multiple horizontal magma sheets. 2–3 cm thick shear zones recognized by intensely cataclasized plagioclase phenocrysts define the contact between sheets. Sheets have bulbous and / or steep frontal terminations and are flat on top. The foliation within the interior of the sheets, near the frontal termination, is subvertical. This steep foliation rotates into the subhorizontal shear zones near the top and bottom contacts and provides a magma flow direction indicator. Away from the frontal termination, the interior foliation rotates to become subhorizontal, similar to the fabric in recent analog experimental studies. Sheets are interpreted as being emplaced as plug flows. Both the field fabric and the rock magnetic data collected from 103 locations on the top of the intrusion and from 73 locations along a vertical cross section exposed in a stream gorge support a multi-stage model of intrusion growth. Emplacement begins as narrow magma channels and magma spreads radially outward from the channels to form sheets. Sheets are stacked upon one another and stop at the same lateral termination. The deformation of the sandstones at the margin of the intrusion, which are rotated upward from the margin to become the roof, is partitioned into layer parallel extension, shearing and layer-parallel shortening components. Bulk strain within the thickest sandstone layer indicates not, vert, similar20% thinning and microstructures indicate that the thinning was accommodated by grain-scale fracture-induced porosity collapse. Extension occurred as the layer was stretched over the margin of the rising intrusion. Shearing and layer-parallel shortening are a result of coupling with the underlying sheets as they advanced and accommodated through numerous faults parallel to bedding and at low angles to bedding. The deformation of thinner sedimentary layers is consistent with the sedimentary layering immediately in front of an advancing sheet being translated upward and over the top of the sheet as the hinge zone migrates with the front edge of the advancing sheet

Magma sheets defined with magnetic susceptibility in the Maiden Creek sill, Henry Mountains, Utah, USA

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Mechanisms and duration of non-tectonically assisted magma emplacement in the upper crust: The Black Mesa pluton, Henry Mountains, Utah

International audienceA new study of Black Mesa pluton (Henry Mountains, Colorado Plateau, Utah, USA) indicates that it is a classic example of a small upper-crustal pluton assembled over a few years by incremental amalgamation of discrete magma pulses. The results of our petrostructural study of the pluton interior allow us to constrain the geometry, kinematics and timing of the processes. The symmetric internal fabric is interpreted as an evidence for a feeding by below and not laterally. The observed rotation of the lineation, from WNW–ESE on the very top to NNE–SSW below, lead us to propose that the fabric at the base of the pluton is a record of magma infilling process, and the fabric at the very top is a record of the strain due to the relative movement between magma and wallrocks. A consequence is that except at the contact between pluton and wallrocks (top and margins), the stretching direction, recorded by the lineation, is not parallel to the flow direction of the magma i.e. displacement. The Black Mesa pluton is a sheeted laccolith on its western edge and a bysmalith on its eastern edge. This E–W asymmetry in pluton geometry/construction and the symmetrical internal fabric indicates that the apparently different west and east growth histories could have occurred simultaneously. Our field data indicate pluton growth through an asymmetric vertical stacking of sill-like horizontal magma sheets. One-dimensional thermal models of the pluton provide maximum limits on the duration of its growth. We have constrained the number, the thickness, and the frequency of magma pulses with our structural observations, including: (1) the emplacement of the pluton by under-accretion of successive magma pulses, (2) the absence of solid-state deformation textures at internal contacts, and (3) the apparent absence of significant recrystallization in the wallrocks. Our results suggest that the emplacement of the Black Mesa pluton was an extremely rapid event, with a maximum duration on the order of 100 years, which requires a minimum vertical displacement rate of the wallrocks immediately above the pluton greater than 2 m/yr. Finally, our data show that the rates of plutonic and volcanic processes could be similar, a significant result for interpretation of magma transfer in arc systems