Effects of prostaglandin analog therapy on the ocular surface of glaucoma patients

Michael B Horsley, Malik Y KahookRocky Mountain Lions Eye Institute, Department of Ophthalmology, University of Colorado Denver, Aurora, CO, USAPurpose: To quantify changes in tear break-up time (TBUT), corneal staining and ocular surface disease index (OSDI) in glaucoma patients after switching therapy from latanoprost with 0.02% benzalkonium chloride (BAK) to travoprost with sofZia™.Methods: Prospective consecutive case series evaluating patients before and 8 weeks after switching from latanoprost with BAK to travoprost with sofZia™ in patients with baseline TBUT less than 6 seconds.Results: Forty eyes of 20 consecutive patients using latanoprost with BAK were switched to travoprost with sofZia™. Mean TBUT prior to starting travoprost was 2.02 ± 0.71 seconds and increased to 6.34 ± 1.31 seconds 8 weeks after the switch (p < 0.001). Mean inferior corneal staining scores decreased from 2.40 ± 0.87 to 1.38 ± 0.59 (p < 0.001). Mean OSDI scores decreased from 26.31 ± 8.25 to 16.56 ± 6.19 (p < 0.001).Discussion: This report focuses on the status of the ocular surface, as documented by TBUT, corneal staining and OSDI, in patients switched from latanoprost with BAK to travoprost without BAK. The switch resulted in a statistically significant increase in TBUT and decreases in corneal staining and OSDI in patients with low baseline TBUT values.Conclusion: BAK, a common preservative for glaucoma drops, may increase OSD by disrupting the tear film and increasing conjunctival inflammation. In this study, a change from a BAK-preserved prostaglandin analog (PGA) to a non-BAK-preserved PGA resulted in a measurable improvement of TBUT, corneal staining and OSDI. Further studies are needed to better understand the impact of BAK-preserved medications on the ocular surface.Keywords: ocular surface, glaucoma, benzalkonium chloride, prostaglandin analo

Time varying gratings model Hawking radiation

Diffraction gratings synthetically moving at trans-luminal velocities contain points where wave and grating velocities are equal. We show these points can be understood as a series of optical event horizons where wave energy can be trapped and amplified, leading to radiation from the quantum vacuum state. We calculate the spectrum of this emitted radiation, finding a quasi-thermal spectrum with features that depend on the grating profile, and an effective temperature that scales exponentially with the length of the grating, emitting a measurable flux even for very small grating contrast.Comment: 13 pages, 4 figure

A lattice evaluation of four-quark operators in the nucleon

Nucleon matrix elements of various four-quark operators are evaluated in quenched lattice QCD using Wilson fermions. Some of these operators give rise to twist-four contributions to nucleon structure functions. Furthermore, they bear valuable information about the diquark structure of the nucleon. Mixing with lower-dimensional operators is avoided by considering appropriate representations of the flavour group. We find that for a certain flavour combination of baryon structure functions, twist-four contributions are very small. This suggests that twist-four effects for the nucleon might be much smaller than m_p^2/Q^2.Comment: 17 pages, 3 figure

Applied lattice gauge calculations: diquark content of the nucleon

As an example of an application of lattice QCD we describe a computation of four-quark operators in the nucleon. The results are interpreted in a diquark language.Comment: 6 pages, 1 figure, Invited talk given by M. G\"ockeler at the European Workshop on the QCD Structure of the Nucleon (QCD - N'02), Ferrara, Italy, 3-6 Apr 200

High-dimensional spatial mode sorting and optical circuit design using multi-plane light conversion

Multi-plane light converters (MPLCs) are an emerging class of optical device capable of converting a set of input spatial light modes to a new target set of output modes. This operation represents a linear optical transformation - a much sought after capability in photonics. MPLCs have potential applications in both the classical and quantum optics domains, in fields ranging from optical communications, to optical computing and imaging. They consist of a series of diffractive optical elements (the 'planes'), typically separated by free-space. The phase delays imparted by each plane are determined by the process of inverse-design, most often using an adjoint algorithm known as the wavefront matching method (WMM), which optimises the correlation between the target and actual MPLC outputs. In this work we investigate high mode capacity MPLCs to create arbitrary spatial mode sorters and linear optical circuits. We focus on designs possessing low numbers of phase planes to render these MPLCs experimentally feasible. To best control light in this scenario, we develop a new inverse-design algorithm, based on gradient ascent with a specifically tailored objective function, and show how in the low-plane limit it converges to MPLC designs with substantially lower modal cross-talk and higher fidelity than achievable using the WMM. We experimentally demonstrate several prototype few-plane high-dimensional spatial mode sorters, operating on up to 55 modes, capable of sorting photons based on their Zernike mode, orbital angular momentum state, or an arbitrarily randomized spatial mode basis. We discuss the advantages and drawbacks of these proof-of-principle prototypes, and describe future improvements. Our work points to a bright future for high-dimensional MPLC-based technologies

A class of invisible inhomogeneous media and the control of electromagnetic waves

We propose a general method to arbitrarily manipulate an electromagnetic wave propagating in a two-dimensional medium, without introducing any scattering. This leads to a whole class of isotropic spatially varying permittivity and permeability profiles that are invisible while shaping the field magnitude and/or phase. In addition, we propose a metamaterial structure working in the infrared that demonstrates deep sub-wavelength control of the electric field amplitude and strong reduction of the scattering. This work offers an alternative strategy to achieve invisibility with isotropic materials and paves the way for tailoring the propagation of light at the nanoscal