Provision of trauma teams in Scotland: a national survey

<b>Background and Aims:</b> Trauma is still the leading cause of mortality in the first four decades of life. Despite multiple reports on how trauma care could be improved in the UK, treatment has been shown to be inconsistent and of poor quality. Trauma teams have been shown to have a positive effect on outcome. We aimed to determine the prevalence of trauma teams in Scotland. <b>Methods:</b> We performed a telephone survey of 24 hospitals with Emergency Departments and spoke to the senior clinician regarding provision of trauma teams. <b>Results:</b> 5 (21%) of the hospitals questioned had trauma teams. The most common reasons for not having one were: no problem with current system 8 (44%) and inability to include senior enough staff on the team 6 (24%). <b>Conclusions:</b> There are few trauma teams in Scottish acute hospitals. There was little enthusiasm for introducing them for a variety of reasons. Local evidence of benefit is likely needed before their adoption becomes widespread

Personal and sub-personal: a defence of Dennett's early distinction

Since 1969, when Dennett introduced a distinction between personal and sub‐personal levels of explanation, many philosophers have used ‘sub‐personal’ very loosely, and Dennett himself has abandoned a view of the personal level as genuinely autonomous. I recommend a position in which Dennett's original distinction is crucial, by arguing that the phenomenon called mental causation is on view only at the properly personal level. If one retains the commit‐’ ments incurred by Dennett's early distinction, then one has a satisfactory anti‐physicalistic, anti‐dualist philosophy of mind. It neither interferes with the projects of sub‐personal psychology, nor encourages ; instrumentalism at the personal level. People lose sight of Dennett’s personal/sub-personal distinction because they free it from its philosophical moorings. A distinction that serves a philosophical purpose is typically rooted in doctrine; it cannot be lifted out of context and continue to do its work. So I shall start from Dennett’s distinction as I read it in its original context. And when I speak of ‘the distinction’, I mean to point not only towards the terms that Dennett first used to define it but also towards the philosophical setting within which its work was cut out

Impact of different handling styles (good vs. adverse) on growth performance, behavior, and cortisol concentrations in beef cattle

Our objective was to determine effects of aggressive handling on growth performance, behavior, and cortisol concentrations in beef calves. Crossbred calves (313 ± 4.7 kg; n = 54; 24 steers, 30 heifers) from a single herd were stratified by gender, body weight, and initial chute score, then allocated randomly to one of six pens. Each pen was randomly assigned to one of two handling treatments (good or adverse) applied on days 7, 35, 63, and 91. The objective of good treatment was to handle the calves quietly and gently to minimize stress. The objective of adverse treatment was to move the calves quickly and expose them to stimuli. Body weight, exit velocity, and chute scores (based on 5 point subjective scale) were recorded and salivary samples for cortisol were collected (4 calves/ pen) on days 0, 7, 35, 63, and 91. Pen scores (5 point subjective scale) were recorded on days 12, 42, and 87. Data were analyzed statistically using a mixed model. Chute scores tended to be higher (more agitated) in the adverse treatment on day 7, but scores did not differ on subsequent days (treatment × day; P = 0.06). Salivary cortisol concentrations on day 63 were greater in cattle on the adverse treatment (treatment × day, P = 0.001). Body weight, exit velocity, and pen scores were not affected by treatment (P ≥ 0.24). While differences were observed, these cattle appeared to acclimate to short-term adverse handling which did not seem to dramatically affect performance or behavior of beef cattle

Resistance Training Volume Load with and without Exercise Displacement

Monitoring the resistance training volume load (VL) (sets × reps × load) is essential to managing resistance training and the recovery–adaptation process. Subjects: Eight trained weightlifters, seven of which were at national level, participated in the study. Methods: VL was measured both with (VLwD) and without (VL) the inclusion of barbell displacement, across twenty weeks of training, in order to allow for comparisons to be made of these VL calculating methods. This consisted of recording the load, repetition count, and barbell displacement for every set executed. Comparisons were made between VL and VLwD for individual blocks of training, select training weeks, and select training days. Results: Strong, statistically significant correlations (r ≥ 0.78, p \u3c 0.001) were observed between VL and VLwD between all training periods analyzed. t-tests revealed statistically significant (p ≤ 0.018) differences between VL and VLwD in four of the seven training periods analyzed. Conclusion: The very strong relationship between VL and VLwD suggest that a coach with time constraints and a large number of athletes can potentially spare the addition of displacement. However, differences in percent change indicate that coaches with ample time should include displacement in VL calculations, in an effort to acquire more precise workload totals

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions. A method capable of profiling a substantial fraction of the surface proteome simultaneously and inexpensively would enable more accurate and complete classification of cell states. We present a highly multiplexed and quantitative surface proteomic method using genetically barcoded antibodies called phage-antibody next-generation sequencing (PhaNGS). Using 144 preselected antibodies displayed on filamentous phage (Fab-phage) against 44 receptor targets, we assess changes in B cell surface proteins after the development of drug resistance in a patient with acute lymphoblastic leukemia (ALL) and in adaptation to oncogene expression in a Myc-inducible Burkitt lymphoma model. We further show PhaNGS can be applied at the single-cell level. Our results reveal that a common set of proteins including FLT3, NCR3LG1, and ROR1 dominate the response to similar oncogenic perturbations in B cells. Linking high-affinity, selective, genetically encoded binders to NGS enables direct and highly multiplexed protein detection, comparable to RNA-sequencing for mRNA. PhaNGS has the potential to profile a substantial fraction of the surface proteome simultaneously and inexpensively to enable more accurate and complete classification of cell states

Arkansas Cooperative Beef Bull Performance Test 1991

Performance testing of beef bulls was initiated to improve productivity of Arkansas beef cattle through breeding. This cooperative testing program provides cattlemen with reliable information for identifying animals with superior breeding value for the traits of production measured in the test. By using the information as a basis for herd sire selection, a breeder can greatly increase the chances of obtaining a bull that will sire rapid-gaining, more efficient, highquality calves. Such calves can increase profits for both the breeder and the feeder. This testing program provides information that is useful to financial institutes in arranging their lending programs and to companies in developing their educational, promotional and marketing programs

Maximum Strength, Rate of Force Development, Jump Height, and Peak Power Alterations in Weightlifters across Five Months of Training

The purpose of this monitoring study was to investigate how alterations in training affect changes in force-related characteristics and weightlifting performance. Subjects: Seven competitive weightlifters participated in the study. Methods: The weightlifters performed a block style periodized plan across 20 weeks. Force plate data from the isometric mid-thigh pull and static jumps with 0 kg, 11 kg, and 20 kg were collected near the end of each training block (weeks 1, 6, 10, 13, 17, and 20). Weightlifting performance was measured at weeks 0, 7, 11, and 20. Results: Very strong correlations were noted between weightlifting performances and isometric rate of force development (RFD), isometric peak force (PF), peak power (PP), and jump height (JH). Men responded in a more predictable manner than the women. During periods of higher training volume, RFD was depressed to a greater extent than PF. JH at 20 kg responded in a manner reflecting the expected fatigue response more so than JH at 0 kg and 11 kg. Conclusions: PF appears to have been more resistant to volume alterations than RFD and JH at 20 kg. RFD and JH at 20 kg appear to be superior monitoring metrics due to their “sensitivity.

Design and performance of the antenna coupled lumped-element kinetic inductance detector

Focal plane arrays consisting of low-noise, polarisation-sensitive detectors have made possible the pioneering advances in the study of the cosmic microwave background (CMB). To make further progress, the next generation of CMB experiments (e.g. CMB-S4) will require a substantial increase in the number of detectors compared to the current stage 3 instruments. Arrays of kinetic inductance detectors (KIDs) provide a possible path to realising such large format arrays owing to their intrinsic multiplexing advantage and relative cryogenic simplicity. In this proceedings, we report on the design of a novel variant of the traditional KID design; the antenna-coupled lumped-element KID. A polarisation sensitive twin-slot antenna placed behind an optimised hemispherical lens couples power onto a thin-film superconducting microstrip line. The power is then guided into the inductive section of an aluminium KID where it is absorbed and modifies both the resonant frequency and quality factor of the KID. We present the various aspects of the design and preliminary results from the first set of seven-element prototype arrays and compare to the expected modelled performance