Seismic Response to Injection Well Stimulation in a High-Temperature, High-Permeability Reservoir

Fluid injection into the Earth's crust can induce seismic events that cause damage to local infrastructure but also offer valuable insight into seismogenesis. The factors that influence the magnitude, location, and number of induced events remain poorly understood but include injection flow rate and pressure as well as reservoir temperature and permeability. The relationship between injection parameters and injection-induced seismicity in high-temperature, high-permeability reservoirs has not been extensively studied. Here we focus on the Ngatamariki geothermal field in the central Taupō Volcanic Zone, New Zealand, where three stimulation/injection tests have occurred since 2012. We present a catalog of seismicity from 2012 to 2015 created using a matched-filter detection technique. We analyze the stress state in the reservoir during the injection tests from first motion-derived focal mechanisms, yielding an average direction of maximum horizontal compressive stress (SHmax) consistent with the regional NE-SW trend. However, there is significant variation in the direction of maximum compressive stress (σ1), which may reflect geological differences between wells. We use the ratio of injection flow rate to overpressure, referred to as injectivity index, as a proxy for near-well permeability and compare changes in injectivity index to spatiotemporal characteristics of seismicity accompanying each test. Observed increases in injectivity index are generally poorly correlated with seismicity, suggesting that the locations of microearthquakes are not coincident with the zone of stimulation (i.e., increased permeability). Our findings augment a growing body of work suggesting that aseismic opening or slip, rather than seismic shear, is the active process driving well stimulation in many environments

A Mindfulness Intervention for Veterans with Post-Traumatic Stress Disorder

Every day, many United States veterans are suffering from the effects of post-traumatic stress disorder (PTSD). Responses to trauma may vary from person to person; however, a diagnosis of PTSD includes the individual experiencing clinically significant distress in their social and occupational areas of functioning. The impact of PTSD on a veteran’s life could impact their ability to carry out activities of daily living, decrease the amount of social participation they have, and limit their ability to perform instrumental daily activities, such as grocery shopping. Mindfulness is the practice of paying full attention to the present moment, without judgment, and has been utilized for centuries. Occupational therapists are qualified mental health practitioners for treating sequelae of PTSD and for utilizing mindfulness interventions in practice. There is limited literature available that evaluates the effectiveness of mindfulness practices with PTSD in an occupational therapy (OT) setting. Though, the literature calls for the creation of an OT mindfulness module for veterans with PTSD. At present, an OT manualized module has yet to be published within the literature. This capstone project sought to fill the gap in literature and provide a resource to occupational therapists looking to utilize mindfulness interventions for veteran clients with PTSD. An OT mindfulness module for veterans with PTSD is presented in this paper.https://soar.usa.edu/otdcapstonesspring2023/1017/thumbnail.jp

Robotic reverberation mapping of the broad-line radio galaxy 3C 120

We carried out photometric and spectroscopic observations of the well-studied broad-line radio galaxy 3C 120 with the Las Cumbres Observatory (LCO) global robotic telescope network from 2016 December to 2018 April as part of the LCO AGN Key Project on Reverberation Mapping of Accretion Flows. Here, we present both spectroscopic and photometric reverberation mapping results. We used the interpolated cross-correlation function (ICCF) to perform multiple-line lag measurements in 3C 120. We find the H$\gamma$, He II $\lambda 4686$, H$\beta$ and He I $\lambda 5876$ lags of $\tau_{\text{cen}} = 18.8_{-1.0}^{+1.3}$, $2.7_{-0.8}^{+0.7}$, $21.2_{-1.0}^{+1.6}$, and $16.9_{-1.1}^{+0.9}$ days respectively, relative to the V-band continuum. Using the measured lag and rms velocity width of the H$\beta$ emission line, we determine the mass of the black hole for 3C 120 to be $M=\left(6.3^{+0.5}_{-0.3}\right)\times10^7\,(f/5.5)$ M$_\odot$. Our black hole mass measurement is consistent with similar previous studies on 3C 120, but with small uncertainties. In addition, velocity-resolved lags in 3C 120 show a symmetric pattern across the H$\beta$ line, 25 days at line centre decreasing to 17 days in the line wings at $\pm4000$ km s$^{-1}$. We also investigate the inter-band continuum lags in 3C 120 and find that they are generally consistent with $\tau\propto\lambda^{4/3}$ as predicted from a geometrically-thin, optically-thick accretion disc. From the continuum lags, we measure the best fit value $\tau_{\rm 0} = 3.5\pm 0.2$ days at $\lambda_{\rm 0} = 5477$A. It implies a disc size a factor of $1.6$ times larger than prediction from the standard disc model with $L/L_{\rm Edd} = 0.4$. This is consistent with previous studies in which larger than expected disc sizes were measured

Performance of On-Line Learning Methods in Predicting Multiprocessor Memory Access Patterns

Shared memory multiprocessors require reconfigurable interconnection networks (INs) for scalability. These INs are reconfigured by an IN control unit. However, these INs are often plagued by undesirable reconfiguration time that is primarily due to control latency, the amount of time delay that the control unit takes to decide on a desired new IN configuration. To reduce control latency, a trainable prediction unit (PU) was devised and added to the IN controller. The PU's job is to anticipate and reduce control configuration time, the major component of the control latency. Three different on-line prediction techniques were tested to learn and predict repetitive memory access patterns for three typical parallel processing applications, the 2-D relaxation algorithm, matrix multiply and Fast Fourier Transform. The predictions were then used by a routing control algorithm to reduce control latency by configuring the IN to provide needed memory access paths before they were requested. Three prediction techniques were used and tested: 1). a Markov predictor, 2). a linear predictor and 3). a time delay neural network (TDNN) predictor. As expected, different predictors performed best on different applications, however, the TDNN produced the best overall results. (Also cross-referenced as UMIACS-TR-96-59

Four Dimensional Black Holes in String Theory

Exact solutions of heterotic string theory corresponding to four-dimensional charge Q magnetic black holes are constructed as tensor products of an SU(2)/Z(2Q+2) WZW orbifold with a (0,1) supersymmetric SU(1,1)/U(1) WZW coset model. The spectrum is analyzed in some detail. ``Bad'' marginal operators are found which are argued to deform these theories to asymptotically flat black holes. Surprising behaviour is found for small values of Q, where low-energy field theory is inapplicable. At the minimal value Q=1, the theory degenerates. Renormalization group arguments are given that suggest the potential gravitational singularity of the low-energy field theory is resolved by a massive two-dimensional field theory. At Q=0, a stable, neutral ``remnant,'' of potential relevance to the black hole information paradox, is found.Comment: 37 pages + 1 figure (tar compressed and uuencoded

RNA Sequencing of Human Peripheral Nerve in Response to Injury: Distinctive Analysis of the Nerve Repair Pathways

The development of regenerative therapies for central nervous system diseases can likely benefit from an understanding of the peripheral nervous system repair process, particularly in identifying potential gene pathways involved in human nerve repair. This study employed RNA sequencing (RNA-seq) technology to analyze the whole transcriptome profile of the human peripheral nerve in response to an injury. The distal sural nerve was exposed, completely transected, and a 1 to 2 cm section of nerve fascicles was collected for RNA-seq from six participants with Parkinson\u27s disease, ranging in age between 53 and 70 yr. Two weeks after the initial injury, another section of the nerve fascicles of the distal and pre-degenerated stump of the nerve was dissected and processed for RNA-seq studies. An initial analysis between the pre-lesion status and the postinjury gene expression revealed 3,641 genes that were significantly differentially expressed. In addition, the results support a clear transdifferentiation process that occurred by the end of the 2-wk postinjury. Gene ontology (GO) and hierarchical clustering were used to identify the major signaling pathways affected by the injury. In contrast to previous nonclinical studies, important changes were observed in molecular pathways related to antiapoptotic signaling, neurotrophic factor processes, cell motility, and immune cell chemotactic signaling. The results of our current study provide new insights regarding the essential interactions of different molecular pathways that drive neuronal repair and axonal regeneration in humans

Pre-Mission Input Requirements to Enable Successful Sample Collection by a Remote Field/EVA Team

We used a field excursion to the West Clearwater Lake Impact structure as an opportunity to test factors that contribute to the decisions a remote field team (for example, astronauts conducting extravehicular activities (EVA) on planetary surfaces) makes while collecting samples for return to Earth. We found that detailed background on the analytical purpose of the samples, provided to the field team, enables them to identify and collect samples that meet specific analytical objectives. However, such samples are not always identifiable during field reconnaissance activities, and may only be recognized after outcrop characterization and interpretation by crew and/or science team members. We therefore recommend that specific time be allocated in astronaut timeline planning to collect specialized samples, that this time follow human or robotic reconnaissance of the geologic setting, and that crew member training should include exposure to the laboratory techniques and analyses that will be used on the samples upon their return to terrestrial laboratories

OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides

Organophosphorus (OP) pesticides poison more than 3,000,000 people every year in the developing world, mostly through intentional self-poisoning. Advances in medical therapy for OP poisoning have lagged, and current treatment is not highly effective with mortality of up to 40% in even the most advanced Western medical facilities. Administration of a broadly active bacterial OP hydrolase to patients in order to hydrolyze OPs in circulation might allow current therapies to be more effective. The objective of this work was to evaluate the efficacy of a new recombinant bacterial OP hydrolase (OpdA), cloned from Agrobacterium radiobacter, in rat models of two chemically distinct but highly toxic and rapidly acting OP pesticides: dichlorvos and parathion. Without OpdA treatment, median time to death in rats poisoned with 3x LD(50) of dichlorvos or parathion was 6 min and 25.5 min, respectively. Administration of a single dose of OpdA immediately after dichlorvos resulted in 100% survival at 24h, with no additional antidotal therapy. After parathion poisoning, OpdA alone caused only a delay to death. However, an additional two doses of OpdA resulted in 62.5% survival at 24 h after parathion poisoning. In combination with pralidoxime therapy, a single dose of OpdA increased survival to 75% after parathion poisoning. Our results demonstrate that OpdA is able to improve survival after poisoning by two chemically distinct and highly toxic OP pesticides

Resolving fine-scale population structure and fishery exploitation using sequenced microsatellites in a northern fish

Funding Information Natural Sciences and Engineering Research Council of Canada (NSERC) Strategic Project Atlantic Canada Opportunities Agency and Department of Tourism, Culture, Industry and Innovation grants allocated to the Labrador Institute (MC) Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Genomics Research and Development Initiative (GRDI) Weston Family AwardPeer reviewedPublisher PD