165 research outputs found
The program of cultural refinement in 19th century Hungary: The Example of Count Széchenyi and Baron Kemény
In an effort to give a historical depth to recent discussions on taste in Aesthetic theory, this paper recovers a 19th century Hungarian paradigm. While taste first came to the forefront of philosophical reflection with the Enlightenment and especially with Kant, by now there is a growing literature on the survival of that discourse in the first half of the 19th century. The present author contributed to the research, which tried to show that in Hungary Count István Széchenyi, an influential political reformer, can be regarded as an author, who for socio-political reasons relied heavily on the British discourse of politeness and taste. This paper aims to show that the same discourse lived on and was employed in the second half of the 19th century in socio-political debates. The example is Baron Zsigmond Kemény, an admirer and follower of Széchenyi, who transformed the discourse into a bourgeois political-educational program
EndogĂ©n szubsztanciák kardiovaszkuláris regulátor szerepĂ©nek molekuláris biolĂłgiai Ă©s biokĂ©miai vizsgálata sebĂ©szi szĂvbetegsĂ©gekben Ă©s állatkĂsĂ©rletes modellekben = Regulatory role of endogenous vasoactive substances in cardiac surgical diseases and in animal models: molecular biological and biochemical background
KifejlesztĂ©sre kerĂĽlt egy Ăşj mĂ©rĂ©si mĂłdszer, mely alkalmas az NT-proANP Ă©s az NT-proBNP egyĂĽttes mĂ©rĂ©sĂ©re (NT-proXNP). Cardiopulmonáris bypasson (CPB) átesett gyerekeken vĂ©gzett vizsgálatainkban az NT-proXNP szignifikáns összefĂĽggĂ©st mutatott az NT-proANP szinttel, de mĂ©g szorosabbat az NT-proBNP-vel, illetve a kĂ©t NP összegĂ©vel. Az NT-proXNP szint szoros korreláciĂłt mutatott a cardiac indexszel, a stroke volume indexszel Ă©s a globális EF-fel a postop. periĂłdusban. Az NT-proXNP tehát jĂł marker a cardiac output utánkövetĂ©sĂ©re gyermekkori szĂvsebĂ©szetben. Preklinikai vizsgálatunkban az inozinnak a szĂvre kifejtett hatásait vizsgálatuk reperfĂşziĂł során cardioplegiás szĂvmegállásnál extracorporalis keringĂ©sű kutyamodelleknĂ©l. EredmĂ©nyeink szerint az inozin alkalmazása javĂtja a cardiális Ă©s endotheliális funkciĂłt hypothermiás szĂvmegállásban vĂ©gzett CPB műtĂ©t után. További experimentális vizsgálatainkat izolált perfĂşziĂłs patkányszĂven vĂ©geztĂĽk. A myocardiumban korábban kimutatott magas számĂş prolactin releasing peptide (PrRP) kötĹ‘helyek kardiális szabályozásban játszott szerepĂ©t vizsgáltuk. Langendorff szerint izolált perfĂşziĂłs patkányszĂven (n=99) a PrRP adása (1-100nM) dĂłzis-dependens pozitĂv inotrĂłp hatást fejt ki. EredmĂ©nyeink egy ez idáig ismeretlen szerepĂ©t tárták fel a PrRP-nek, miszerint direkt pozitĂv inotrĂłp hatással van a szĂvizomra. | A novel diagnostic method was developped which incorporates information about the concentrations of both NT-proANP, NT-proBNP. In our children patients undergoing cardiac operation with cardiopulmonary bypass (CPB) the NT-proXNP level correlated significantly with the NT-proANP level, but more strongly with the NT-proBNP and the arithmetic sum of both. NT-proXNP had a strong correlation with cardiac index, the stroke volume index and the global EF throughout the post-operative period. NT-proXNP is a good marker of cardiac output following pediatric cardiac surgery In a pre-clinical study, we investigated the effects of inosine on cardiac function during reperfusion in experimental dogs model of cardioplegic arrest and extracorporal circulation. In conclusions the application of inosine improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest. In our additional experimental study isolated perfused rat hearts were made. High levels of specific prolactin-releasing peptide (PrRP) binding sites have been found in the myocardium; however, the functional importance of PrRP in the regulation of cardiac function is unknown. In isolated perfused rat hearts, infusion of PrRP (1–100 nM) induced a dose-dependent positive inotropic effect. In conclusion, the present data define a hitherto unrecognized role for PrRP in the regulation of cardiovascular system by showing that PrRP exerts a direct positive inotropic effect
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