Biomedical abbreviation recognition and resolution by PROSA-MED

The amount of abbreviations used in biomedical literature increases constantly. Despite the existence of acronym dictionaries, it is not viable to keep them updated with new creations. Thus, in the processing of biomedical texts, discovering and disambiguating acronyms and their expanded forms are essential aspects and this is the objective proposed by BARR task at IberEval 2017 Workshop. This paper presents our participation in this task. We propose five systems that deal with the problem in different ways. Three of the systems are atomic approaches, while two of them are combinations of the atomic systems. One of the systems clearly outperforms the others, both in the detection of entities (F-score of 0.749 in the test set) as well as identifying relations between short-long forms (F-score of 0.697 in the test set).Peer ReviewedPostprint (published version

Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control

Abstract Introduction Surgical resection and systemic chemotherapy with temozolomide remain the mainstay for treatment of glioblastoma. However, many patients are not candidates for surgical resection given inaccessible tumor location or poor health status. Furthermore, despite being first line treatment, temozolomide has only limited efficacy. Methods The development of injectable hydrogel-based carrier systems allows for the delivery of a wide range of chemotherapeutics that can achieve high local concentrations, thus potentially avoiding systemic side effects and wide-spread neurotoxicity. To test this modality in a realistic environment, we developed a diblock copolypeptide hydrogel (DCH) capable of carrying and releasing paclitaxel, a compound that we found to be highly potent against primary gliomasphere cells. Results The DCH produced minimal tissue reactivity and was well tolerated in the immune-competent mouse brain. Paclitaxel-loaded hydrogel induced less tissue damage, cellular inflammation and reactive astrocytes than cremaphor-taxol (typical taxol-carrier) or hydrogel alone. In a deep subcortical xenograft model, of glioblastoma in immunodeficient mice, injection of paclitaxel-loaded hydrogel led to a high local concentration of paclitaxel and led to local tumor control and improved survival. However, the tumor cells were highly migratory and were able to eventually escape the area of treatment. Conclusions These findings suggest this technology may be ultimately applicable to patients with deep-seated inoperable tumors, but as currently formulated, complete tumor eradication would be highly unlikely. Future studies should focus on targeting the migratory potential of surviving cells

Parallel implementation of fuzzy minimals clustering algorithm

Clustering aims to classify different patterns into groups called clusters. Many algorithms for both hard and fuzzy clustering have been developed to deal with exploratory data analysis in many contexts such as image processing, pattern recognition, etc. However, we are witnessing the era of big data computing where computing resources are becoming the main bottleneck to deal with those large datasets. In this context, sequential algorithms need to be redesigned and even rethought to fully leverage the emergent massively parallel architectures. In this paper, we propose a parallel implementation of the fuzzy minimals clustering algorithm called Parallel Fuzzy Minimal (PFM). Our experimental results reveal linear speed-up of PFM when compared to the sequential counterpart version, keeping very good classification quality.Ingeniería, Industria y Construcció

Phase diagram of Fe-doped Ni-Mn-Ga ferromagnetic shape-memory alloys

We have studied the effect of Fe addition on the structural and magnetic transitions in the magnetic shape memory alloy Ni-Mn-Ga by substituting systematically each atomic species by Fe. Calorimetric and AC susceptibility measurements have been carried out in order to study the magnetic and structural transformation properties. We find that the addition of Fe modifies the structural and magnetic transformation temperatures. Magnetic transition temperatures are displaced to higher values when Fe is substituted into Ni-Mn-Ga, while martensitic and premartensitic transformation temperatures shift to lower values. Moreover, it has been found that the electron per atom concentration essentially governs the phase stability in the quaternary system. However, the observed scaling of transition temperatures with $e/a$ differs from that reported in the related ternary system Ni-Mn-Ga.Comment: 8 pages, 8 figures. Accepted for publication in the Physical Review

The accounting of the Real e Ilustre cofradía de Nuestro padre Jesus Nazareno of Cartagena during the second third of the twentieth century

[SPA] Las Cofradías de Semana Santa son instituciones centenarias en España. Así, la Real e Ilustre Cofradía de Nuestro Padre Jesús Nazareno de Cartagena, conocida con el apelativo de Cofradía Marraja o marrajos, es la más antigua de la ciudad. El objetivo del presente trabajo es, mediante el análisis de la contabilidad y de los estatutos de dicha Cofradía en el periodo comprendido en el segundo tercio del siglo XX, determinar la calidad de la información contable, su comparabilidad entre distintos periodos y su funcionalidad como instrumento de gestión en un periodo delicado de transformación y reinstitucionalización por el contexto político y social de dicha época.[ENG] Religious Brotherhoods are centennial Institutions in Spain. Thus, the Real e Ilustre Cofradía de Nuestro Padre Jesús Nazareno of Cartagena, generally known as Marraja Brotherhood, is the oldest of the city. The objective if this investigation is, by analyzing the accounting and the statutes of the Brotherhood in the period in the second third of the twentieth century, determining the quality of accounting information, comparability between different periods and functionality as an instrument management in a delicate period of transformation and re-institutionalization for political and social context of that time

Arsenic removal from groundwater: technological design for rural areas

A technological design for water processing for rural and peri-urban areas with no drinking water was created as part of a general project aimed at treating groundwater containing arsenic values higher than those established by the WHO (10 μg L-1) for consumption. The construction of treatment equipments (batch type) is simple and operatively easy. The adsorbent is a low-cost, Fe-rich and clay mineral that is abundant in Buenos Aires Province. Local conditions of water, particularly physicochemical properties, have been taken into account to adapt the process which operates with volumes from 2000 to 4000 L of water/stage. Three plants have been installed in schools of rural areas of Buenos Aires Province. A new plant is being constructed in Inchausti School of the UNLP located in 25 de Mayo city. The equipments provide water in educational buildings and nearby populations. Some technical data about the process are reported in this communication. It is necessary to mention that the first prototype, which was installed two years ago, has been continuously used without having replaced the adsorbent so far. It has processed 400000 L of water whose original concentration of arsenic was around 200 μg L-1 that now reaches values lower than 10 μg L-1.En el marco de un proyecto general dirigido al tratamiento de aguas subterráneas para consumo, conteniendo valores de arsénico superiores a los establecidos por la OMS (10 μg L-1), se ha abordado, el diseño de una tecnología de procesamiento de aguas para ser instalada en zonas rurales y peri-urbanas, carentes de aguas de red. Se ha logrado la construcción de equipos de tratamiento de tipo discontinuo, de simple construcción y facilidad operativa, en base a las condiciones locales, particularmente, las condiciones fisicoquímicas de las aguas. Se emplea como adsorbente mineral de arcilla rico en hierro, de bajo costo y abundante en la provincia de Buenos Aires. El proceso, que permite trabajar con volúmenes de entre 2000 y 4000 L de agua/ etapa, se basa en el empleo de adsorbentes minerales de bajo costo y amplia distribución en la provincia de Buenos Aires. Se instalaron hasta el presente tres plantas en escuelas de zonas rurales de la Provincia de Buenos Aires, y está en etapa de construcción una planta en la Escuela Inchausti, perteneciente a la UNLP, sita en la localidad de 25 de Mayo, asegurando la provisión de agua en los establecimientos educativos y poblaciones cercanas. En esta comunicación se reportan datos técnicos relativos al funcionamiento y parámetros operacionales de las plantas. El primer prototipo instalado lleva más de 2 años de uso continuo sin recambio de la carga de adsorbente; ha procesado 400 mil litros de agua cuya concentración original de As, del orden de las 200 μg L-1, llega a valores de 10 μg L-1.Fil: Soto, Edgardo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Planta Piloto Multiproposito; ArgentinaFil: González, María José. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Instituto de Recursos Minerales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Química Inorgánica; ArgentinaFil: Thomas, Horacio Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Planta Piloto Multiproposito; ArgentinaFil: Schalamuk, Bernardo Isidoro. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Instituto de Recursos Minerales; ArgentinaFil: Botto, Irma Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Química Inorgánica; Argentin

Elastocaloric effect in Ti-Ni shape-memory wires associated with the B2 ↔ B19' and B2 ↔ R structural transitions

"We have studied the elastocaloric properties of Ti-Ni shape-memory wires subjected to specific heat treatments to decouple the B2 R transition from the B2 B19' one. The entropy values at moderate stresses (similar to 170 MPa) for the B2 B19' transition are remarkably high (in the range 60-80 J/kg K). However, in spite of the B2 R transition exhibits significantly lower entropy changes (similar to 12 J/kg K), the much smaller hysteresis of this transition gives rise to a larger reversible elastocaloric effect for low applied stresses. Therefore, the reversible elastocaloric strength associated with the B2 R is larger than the elastocaloric strength associated with the B2 B19' transition.

Effect of polyunsaturated fatty acid deficiency on dipole relaxation in the membrane interface of rat liver microsomes

AbstractThe influence of a fat-free diet on the lipid dynamics of rat liver microsomes and liposomes of microsomal lipids was studied by using different fluorescence methods. Lifetime distribution and rotational diffusion of probes with different localization in the lipid bilayer were measured using multifrequency fluorometry. Lateral mobility was studied by measuring excimer formation of pyrenedodecanoic acid. Dipolar relaxation in the interfacial region was studied using 2-dimethylamino-6-lauroylnaphthalene (Laurdan). In spite of large changes in the fatty acid composition of microsomal lipids, polyunsaturated fatty acid deficiency showed no effect on the lifetime distribution and rotational mobility of 1,6-diphenyl-1,3,5-hexatriene (DPH), 1-(4-(trimethylamino)phenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH), 2-, 7- and 12-(9-anthroiloxy)stearic acids. The treatment did not change the lateral diffusion of pyrenedodecanoic acid, either. However, generalized polarization of Laurdan fluorescence was higher in polyunsaturated fatty acid deficient microsomes as compared to the polyunsaturated fatty acid sufficient ones. This effect was also observed in liposomes of the total microsomal lipids, indicating that the changes in fatty acid composition resulting from polyunsaturated fatty acid deficiency produced a small but significant decrease in the rate of dipolar relaxation in the region of the lipid polar groups of the bilayer. The absence of lipid gel phase domains in rat liver microsomes was also indicated by Laurdan fluorescence features

Sociotechnical Construction of the pilot of Digital Repository of the National University of the Arts: Rid-UNA

El presente trabajo atiende a la búsqueda de soluciones más satisfactorias para la publicación de Objetos Digitales provenientes del campo académico artístico en los Repositorios Institucionales de Acceso Abierto, a los fines de asegurar su visibilidad e interoperabilidad. En este sentido, se exponen los avances del proyecto “Construcción sociotécnica del Repositorio Institucional Digital piloto de la Universidad Nacional de las Artes”, acreditado y subsidiado por el Sistema Nacional de Repositorios Digitales del Ministerio de Ciencia, Tecnología e Innovación productiva de Argentina. Los objetivos se centran en generar una ciberinfraestructura adecuada para la puesta en producción y sostenibilidad del repositorio. La misma solicita la implementación técnica del software DSpace con una configuración e interfaz acorde a los requerimientos del perfil institucional, la conformación de un equipo de trabajo que asegure una organización de base para la sostenibilidad del repositorio y acciones consensuadas de promoción y gestión sobre las políticas institucionales de publicación en acceso abierto. En lo metodológico se adoptó un enfoque de investigación y desarrollo sociotécnico de carácter interdisciplinar. Los resultados alcanzados muestran un avance en lo organizacional a nivel institucional, un prototipo de repositorio puesto en línea con 1.106 producciones ya disponibles e interoperables.This paper addresses the research for more satisfactory solutions for the publication of Digital Objects from the artistic academic field in the Open Access Institutional Repositories, in order to ensure their visibility and interoperability. In this sense, we present the progress of the project “Sociotechnical Construction of the pilot of Digital Repository of the National University of the Arts (UNA)”, accredited by the National System of Digital Repositories of the Ministry of Science, Technology and Productive Innovation of Argentina. The objectives are focused on generating an appropriate cyberinfrastructure for the production and sustainability of the repository. It requests the technical implementation of a DSpace software with a configuration and interface according to the requirements of the institutional profile, the formation of a work team that ensures the sustainability of the repository and consensual actions of promotion and management on the policies of institutional publications in open access. Methodologically, we adopted a sociotechnical and interdisciplinary approach of research. The results show an organizational advance in the institutional level, a prototype repository put online with 1106 productions already available and interoperability.Universidad Nacional de La Plat

Sociotechnical Construction of the pilot of Digital Repository of the National University of the Arts: Rid-UNA

El presente trabajo atiende a la búsqueda de soluciones más satisfactorias para la publicación de Objetos Digitales provenientes del campo académico artístico en los Repositorios Institucionales de Acceso Abierto, a los fines de asegurar su visibilidad e interoperabilidad. En este sentido, se exponen los avances del proyecto “Construcción sociotécnica del Repositorio Institucional Digital piloto de la Universidad Nacional de las Artes”, acreditado y subsidiado por el Sistema Nacional de Repositorios Digitales del Ministerio de Ciencia, Tecnología e Innovación productiva de Argentina. Los objetivos se centran en generar una ciberinfraestructura adecuada para la puesta en producción y sostenibilidad del repositorio. La misma solicita la implementación técnica del software DSpace con una configuración e interfaz acorde a los requerimientos del perfil institucional, la conformación de un equipo de trabajo que asegure una organización de base para la sostenibilidad del repositorio y acciones consensuadas de promoción y gestión sobre las políticas institucionales de publicación en acceso abierto. En lo metodológico se adoptó un enfoque de investigación y desarrollo sociotécnico de carácter interdisciplinar. Los resultados alcanzados muestran un avance en lo organizacional a nivel institucional, un prototipo de repositorio puesto en línea con 1.106 producciones ya disponibles e interoperables.This paper addresses the research for more satisfactory solutions for the publication of Digital Objects from the artistic academic field in the Open Access Institutional Repositories, in order to ensure their visibility and interoperability. In this sense, we present the progress of the project “Sociotechnical Construction of the pilot of Digital Repository of the National University of the Arts (UNA)”, accredited by the National System of Digital Repositories of the Ministry of Science, Technology and Productive Innovation of Argentina. The objectives are focused on generating an appropriate cyberinfrastructure for the production and sustainability of the repository. It requests the technical implementation of a DSpace software with a configuration and interface according to the requirements of the institutional profile, the formation of a work team that ensures the sustainability of the repository and consensual actions of promotion and management on the policies of institutional publications in open access. Methodologically, we adopted a sociotechnical and interdisciplinary approach of research. The results show an organizational advance in the institutional level, a prototype repository put online with 1106 productions already available and interoperability.Universidad Nacional de La Plat