2,256 research outputs found
Two-phase stretching of molecular chains
While stretching of most polymer chains leads to rather featureless
force-extension diagrams, some, notably DNA, exhibit non-trivial behavior with
a distinct plateau region. Here we propose a unified theory that connects
force-extension characteristics of the polymer chain with the convexity
properties of the extension energy profile of its individual monomer subunits.
Namely, if the effective monomer deformation energy as a function of its
extension has a non-convex (concave up) region, the stretched polymer chain
separates into two phases: the weakly and strongly stretched monomers.
Simplified planar and 3D polymer models are used to illustrate the basic
principles of the proposed model. Specifically, we show rigorously that when
the secondary structure of a polymer is mostly due to weak non-covalent
interactions, the stretching is two-phase, and the force-stretching diagram has
the characteristic plateau. We then use realistic coarse-grained models to
confirm the main findings and make direct connection to the microscopic
structure of the monomers. We demostrate in detail how the two-phase scenario
is realized in the \alpha-helix, and in DNA double helix. The predicted plateau
parameters are consistent with single molecules experiments. Detailed analysis
of DNA stretching demonstrates that breaking of Watson-Crick bonds is not
necessary for the existence of the plateau, although some of the bonds do break
as the double-helix extends at room temperature. The main strengths of the
proposed theory are its generality and direct microscopic connection.Comment: 16 pges, 22 figure
Brillouin scattering studies in FeO across the Verwey transition
Brillouin scattering studies have been carried out on high quality single
crystals of FeO with [100] and [110] faces in the temperature range of
300 to 30 K. The room temperature spectrum shows a surface Rayleigh wave (SRW)
mode at 8 GHz and a longitudinal acoustic (LA) mode at 60 GHz. The SRW mode
frequency shows a minimum at the Verwey transition temperature of 123 K.
The softening of the SRW mode frequency from about 250 K to can be
quantitatively understood as a result of a decrease in the shear elastic
constant C, arising from the coupling of shear strain to charge
fluctuations. On the other hand, the LA mode frequency does not show any
significant change around , but shows a large change in its intensity. The
latter shows a maximum at around 120 K in the cooling run and at 165 K in the
heating run, exhibiting a large hysteresis of 45 K. This significant change in
intensity may be related to the presence of stress-induced ordering of
Fe and Fe at the octahedral sites, as well as to stress-induced
domain wall motion.Comment: 14 pages, 3 figures, accepted in Physical Review B 200
Gyroscopic Precession and Inertial Forces in Axially Symmetric Stationary Spacetimes
We study the phenomenon of gyroscopic precession and the analogues of
inertial forces within the framework of general relativity. Covariant
connections between the two are established for circular orbits in stationary
spacetimes with axial symmetry. Specializing to static spacetimes, we prove
that gyroscopic precession and centrifugal force both reverse at the photon
orbits. Simultaneous non-reversal of these in the case of stationary spacetimes
is discussed. Further insight is gained in the case of static spacetime by
considering the phenomena in a spacetime conformal to the original one.
Gravi-electric and gravi-magnetic fields are studied and their relation to
inertial forces is established.Comment: 21 pages, latex, no figures, http://202.41.67.76/~nayak/gpifass.te
Origin of atomic clusters during ion sputtering
Previous studies have shown that the size distributions of small clusters ( n<=40 n = number of atoms/cluster) generated by sputtering obey an inverse power law with an exponent between -8 and -4. Here we report electron microscopy studies of the size distributions of larger clusters ( n>=500) sputtered by high-energy ion impacts. These new measurements also yield an inverse power law, but one with an exponent of -2 and one independent of sputtering yield, indicating that the large clusters are produced when shock waves, generated by subsurface displacement cascades, ablate the surface
A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR
Double-quantum magic-angle-spinning NMR experiments were performed on 11,12-C-13(2)-retinylidene-rhodopsin under illumination at low temperature, in order to characterize torsional angle changes at the C11-C12 photoisomerization site. The sample was illuminated in the NMR rotor at low temperature (similar to 120 K) in order to trap the primary photointermediate, bathorhodopsin. The NMR data are consistent with a strong torsional twist of the HCCH moiety at the isomerization site. Although the HCCH torsional twist was determined to be at least 40A degrees, it was not possible to quantify it more closely. The presence of a strong twist is in agreement with previous Raman observations. The energetic implications of this geometric distortion are discussed
Revisiting the influence of institutional forces on the written business plan:A replication study
The present paper re-analyzes and extends a study on institutional forces and the written business plan (Honig and Karlsson in J Manag 30(1):29–48, 2004). We attempt to examine to what extent critical decision making is evident in model and variable choice, and whether the implications provided by systematic replication efforts may serve to provide additional and perhaps unrecognized theoretical and/or empirical observations. We find that the key result—formal business planning does not affect performance, does not hold. In fact, we find evidence that formal business planning affects survival but not profitability. The re-analysis also reveals, that institutional antecedents to formal planning appear to be fragile and prone to researcher biases due to different coding and assumptions. Our study underscores the consequences of access to original data and coding material, and to rely upon current methodological explanations for subsequent analyses
Quantum Information Processing with Ferroelectrically Coupled Quantum Dots
I describe a proposal to construct a quantum information processor using
ferroelectrically coupled Ge/Si quantum dots. The spin of single electrons form
the fundamental qubits. Small (<10 nm diameter) Ge quantum dots are optically
excited to create spin polarized electrons in Si. The static polarization of an
epitaxial ferroelectric thin film confines electrons laterally in the
semiconductor; spin interactions between nearest neighbor electrons are
mediated by the nonlinear process of optical rectification. Single qubit
operations are achieved through "g-factor engineering" in the Ge/Si structures;
spin-spin interactions occur through Heisenberg exchange, controlled by
ferroelectric gates. A method for reading out the final state, while required
for quantum computing, is not described; electronic approaches involving single
electron transistors may prove fruitful in satisfying this requirement.Comment: 10 pages, 3 figure
Unraveling the developmental roadmap toward human brown adipose tissue
Increasing brown adipose tissue (BAT) mass and activation is a therapeutic strategy to treat obesity and complications. Obese and diabetic patients possess low amounts of BAT, so an efficient way to expand their mass is necessary. There is limited knowledge about how human BAT develops, differentiates, and is optimally activated. Accessing human BAT is challenging, given its low volume and anatomical dispersion. These constraints make detailed BAT-related developmental and functional mechanistic studies in humans virtually impossible. We have developed and characterized functionally and molecularly a new chemically defined protocol for the differentiation of human pluripotent stem cells (hPSCs) into brown adipocytes (BAs) that overcomes current limitations. This protocol recapitulates step by step the physiological developmental path of human BAT. The BAs obtained express BA and thermogenic markers, are insulin sensitive, and responsive to β-adrenergic stimuli. This new protocol is scalable, enabling the study of human BAs at early stages of development
Hydration interactions: aqueous solvent effects in electric double layers
A model for ionic solutions with an attractive short-range pair interaction
between the ions is presented. The short-range interaction is accounted for by
adding a quadratic non-local term to the Poisson-Boltzmann free energy. The
model is used to study solvent effects in a planar electric double layer. The
counter-ion density is found to increase near the charged surface, as compared
with the Poisson-Boltzmann theory, and to decrease at larger distances. The ion
density profile is studied analytically in the case where the ion distribution
near the plate is dominated only by counter-ions. Further away from the plate
the density distribution can be described using a Poisson-Boltzmann theory with
an effective surface charge that is smaller than the actual one.Comment: 11 Figures in 13 files + LaTex file. 20 pages. Accepted to Phys. Rev.
E. Corrected typos and reference
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