Multi-physics simulation of friction stir welding process

Purpose: The Friction Stir Welding (FSW) process comprises of several highly coupled (and non-linear) physical phenomena: large plastic deformation, material flow transportation, mechanical stirring of the tool, tool-workpiece surface interaction, dynamic structural evolution, heat generation from friction and plastic deformation, etc. In this paper, an advanced Finite Element (FE) model encapsulating this complex behavior is presented and various aspects associated with the FE model such as contact modeling, material model and meshing techniques are discussed in detail. Methodology: The numerical model is continuum solid mechanics-based, fully thermomechanically coupled and has successfully simulated the friction stir welding process including plunging, dwelling and welding stages. Findings: The development of several field variables are quantified by the model: temperature, stress, strain, etc. Material movement is visualized by defining tracer particles at the locations of interest. The numerically computed material flow patterns are in very good agreement with the general findings from experiments. Value: The model is, to the best of the authors’ knowledge, the most advanced simulation of FSW published in the literature

Quantum walks as a probe of structural anomalies in graphs

We study how quantum walks can be used to find structural anomalies in graphs via several examples. Two of our examples are based on star graphs, graphs with a single central vertex to which the other vertices, which we call external vertices, are connected by edges. In the basic star graph, these are the only edges. If we now connect a subset of the external vertices to form a complete subgraph, a quantum walk can be used to find these vertices with a quantum speedup. Thus, under some circumstances, a quantum walk can be used to locate where the connectivity of a network changes. We also look at the case of two stars connected at one of their external vertices. A quantum walk can find the vertex shared by both graphs, again with a quantum speedup. This provides an example of using a quantum walk in order to find where two networks are connected. Finally, we use a quantum walk on a complete bipartite graph to find an extra edge that destroys the bipartite nature of the graph.Comment: 10 pages, 2 figure

Projection-Based Reduced Order Modeling for Spacecraft Thermal Analysis

This paper presents a mathematically rigorous, subspace projection-based reduced order modeling (ROM) methodology and an integrated framework to automatically generate reduced order models for spacecraft thermal analysis. Two key steps in the reduced order modeling procedure are described: (1) the acquisition of a full-scale spacecraft model in the ordinary differential equation (ODE) and differential algebraic equation (DAE) form to resolve its dynamic thermal behavior; and (2) the ROM to markedly reduce the dimension of the full-scale model. Specifically, proper orthogonal decomposition (POD) in conjunction with discrete empirical interpolation method (DEIM) and trajectory piece-wise linear (TPWL) methods are developed to address the strong nonlinear thermal effects due to coupled conductive and radiative heat transfer in the spacecraft environment. Case studies using NASA-relevant satellite models are undertaken to verify the capability and to assess the computational performance of the ROM technique in terms of speed-up and error relative to the full-scale model. ROM exhibits excellent agreement in spatiotemporal thermal profiles (<0.5% relative error in pertinent time scales) along with salient computational acceleration (up to two orders of magnitude speed-up) over the full-scale analysis. These findings establish the feasibility of ROM to perform rational and computationally affordable thermal analysis, develop reliable thermal control strategies for spacecraft, and greatly reduce the development cycle times and costs

Hard X-ray observation and multiwavelength study of the PeVatron candidate pulsar wind nebula "Dragonfly"

We studied the PeVatron nature of the pulsar wind nebula G75.2+0.1 ("Dragonfly") as part of our NuSTAR observational campaign of energetic PWNe. The Dragonfly is spatially coincident with LHAASO J2018+3651 whose maximum photon energy is 0.27 PeV. We detected a compact (radius 1') inner nebula of the Dragonfly without a spectral break in 3 $-$ 20 keV using NuSTAR. A joint analysis of the inner nebula with the archival Chandra and XMM-Newton observations yields a power-law spectrum with $\Gamma=1.49\pm0.03$. Synchrotron burnoff is observed from the shrinkage of the NuSTAR nebula at higher energies, from which we infer the magnetic field in the inner nebula of 24 $\mu$G at 3.5 kpc. Our analysis of archival XMM data and 13 years of Fermi-LAT data confirms the detection of an extended (~10') outer nebula in 2 $-$ 6 keV ($\Gamma=1.82\pm0.03$) and non-detection of a GeV nebula, respectively. Using the VLA, XMM, and HAWC data, we modeled a multi-wavelength spectral energy distribution of the Dragonfly as a leptonic PeVatron. The maximum injected particle energy of 1.4 PeV from our model suggests that the Dragonfly is likely a PeVatron. Our model prediction of the low magnetic field (2.7 $\mu$G) in the outer nebula and recent interaction with the host supernova remnant's reverse shock (4 kyrs ago) align with common features of PeVatron PWNe. The origin of its highly asymmetric morphology, pulsar proper motion, PWN-SNR interaction, and source distance will require further investigations in the future including a multi-wavelength study using radio, X-ray, and gamma-ray observations.Comment: 18 pages, 11 figures, ApJ accepte

Ice-templating of core/shell microgel fibers through 'Bricks-and-Mortar' assembly

通讯作者地址: Stucky, GD (通讯作者), Univ Calif Santa Barbara, Mat Res Lab, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 地址: 1. Univ Calif Santa Barbara, Mat Res Lab, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 电子邮件地址: [email protected] 'bricks-and-mortar' assembly approach can be used to create well-defined fibers on the microscale with alternating organic-inorganic arrangement through a simple ice-templating strategy. ne fibers are constructed from closely packed monodisperse inorganic nanoparticles@PNIPAm core/shelf microgels. A series of functional 'bricks', such as core/shell and hollow nanoparticles are prepared

The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site

AbstractBackground: Hepatocyte growth factor (HGF) is a multipotent growth factor that transduces a wide range of biological signals, including mitogenesis, motogenesis, and morphogenesis. The N-terminal (N) domain of HGF, containing a hairpin-loop region, is important for receptor binding and the potent biological activities of HGF. The N domain is also the primary binding site for heparin or heparan sulfate, which enhances receptor/ligand oligomerization and modulates receptor-dependent mitogenesis. The rational design of artificial modulators of HGF signaling requires a detailed understanding of the structures of HGF and its receptor, as well as the role of heparin proteoglycan; this study represents the first step towards that goal.Results: We report here a high-resolution solution structure of the N domain of HGF. This first structure of HGF reveals a novel folding topology with a distinct pattern of charge distribution and indicates a possible heparin-binding site.Conclusions: The hairpin-loop region of the N domain plays a major role in stabilizing the structure and contributes to a putative heparin-binding site, which explains why it is required for biological functions. These results suggest several basic and/or polar residues that may be important for use in further mutational studies of heparin binding

Identification and Dynamics of a Heparin-Binding Site in Hepatocyte Growth Factor †

Hepatocyte growth factor (HGF) is a heparin-binding, multipotent growth factor that transduces a wide range of biological signals, including mitogenesis, motogenesis, and morphogenesis. Heparin or closely related heparan sulfate has profound effects on HGF signaling. A heparin-binding site in the N-terminal (N) domain of HGF was proposed on the basis of the clustering of surface positive charges [Zhou, H., Mazzulla, M. J., Kaufman, J. D., Stahl, S. J., Wingfield, P. T., Rubin, J. S., Bottaro, D. P., and Byrd, R. A. (1998) Structure 6, 109-116]. In the present study, we confirmed this binding site in a heparin titration experiment monitored by nuclear magnetic resonance spectroscopy, and we estimated the apparent dissociation constant (K(d)) of the heparin-protein complex by NMR and fluorescence techniques. The primary heparin-binding site is composed of Lys60, Lys62, and Arg73, with additional contributions from the adjacent Arg76, Lys78, and N-terminal basic residues. The K(d) of binding is in the micromolar range. A heparin disaccharide analogue, sucrose octasulfate, binds with similar affinity to the N domain and to a naturally occurring HGF isoform, NK1, at nearly the same region as in heparin binding. (15)N relaxation data indicate structural flexibility on a microsecond-to-millisecond time scale around the primary binding site in the N domain. This flexibility appears to be dramatically reduced by ligand binding. On the basis of the NK1 crystal structure, we propose a model in which heparin binds to the two primary binding sites and the N-terminal regions of the N domains and stabilizes an NK1 dimer

Chiral patterns arising from electrostatic growth models

Recently, unusual and strikingly beautiful seahorse-like growth patterns have been observed under conditions of quasi-two-dimensional growth. These `S'-shaped patterns strongly break two-dimensional inversion symmetry; however such broken symmetry occurs only at the level of overall morphology, as the clusters are formed from achiral molecules with an achiral unit cell. Here we describe a mechanism which gives rise to chiral growth morphologies without invoking microscopic chirality. This mechanism involves trapped electrostatic charge on the growing cluster, and the enhancement of growth in regions of large electric field. We illustrate the mechanism with a tree growth model, with a continuum model for the motion of the one-dimensional boundary, and with microscopic Monte Carlo simulations. Our most dramatic results are found using the continuum model, which strongly exhibits spontaneous chiral symmetry breaking, and in particular finned `S' shapes like those seen in the experiments.Comment: RevTeX, 12 pages, 9 figure