RAPS: A Novel Few-Shot Relation Extraction Pipeline with Query-Information Guided Attention and Adaptive Prototype Fusion

Few-shot relation extraction (FSRE) aims at recognizing unseen relations by learning with merely a handful of annotated instances. To generalize to new relations more effectively, this paper proposes a novel pipeline for the FSRE task based on queRy-information guided Attention and adaptive Prototype fuSion, namely RAPS. Specifically, RAPS first derives the relation prototype by the query-information guided attention module, which exploits rich interactive information between the support instances and the query instances, in order to obtain more accurate initial prototype representations. Then RAPS elaborately combines the derived initial prototype with the relation information by the adaptive prototype fusion mechanism to get the integrated prototype for both train and prediction. Experiments on the benchmark dataset FewRel 1.0 show a significant improvement of our method against state-of-the-art methods.Comment: 9 pages, 2 figure

Gene 33/Mig6 Inhibits Hexavalent Chromium-Induced DNA Damage and Cell Transformation in Human Lung Epithelial Cells

Hexavalent Chromium [Cr(VI)] compounds are human lung carcinogens and environmental/occupational hazards. The molecular mechanisms of Cr(VI) carcinogenesis appear to be complex and are poorly defined. In this study, we investigated the potential role of Gene 33 (ERRFI1, Mig6), a multifunctional adaptor protein, in Cr(VI)-mediated lung carcinogenesis. We show that the level of Gene 33 protein is suppressed by both acute and chronic Cr(VI) treatments in a dose- and time-dependent fashion in BEAS-2B lung epithelial cells. The inhibition also occurs in A549 lung bronchial carcinoma cells. Cr(VI) suppresses Gene 33 expression mainly through post-transcriptional mechanisms, although the mRNA level of gene 33 also tends to be lower upon Cr(VI) treatments. Cr(VI)-induced DNA damage appears primarily in the S phases of the cell cycle despite the high basal DNA damage signals at the G2M phase. Knockdown of Gene 33 with siRNA significantly elevates Cr(VI)-induced DNA damage in both BEAS-2B and A549 cells. Depletion of Gene 33 also promotes Cr(VI)-induced micronucleus (MN) formation and cell transformation in BEAS-2B cells. Our results reveal a novel function of Gene 33 in Cr(VI)-induced DNA damage and lung epithelial cell transformation. We propose that in addition to its role in the canonical EGFR signaling pathway and other signaling pathways, Gene 33 may also inhibit Cr(VI)-induced lung carcinogenesis by reducing DNA damage triggered by Cr(VI)

Gene 33/Mig6 Regulates Apoptosis and the DNA Damage Response through Independent Mechanisms

Gene 33 (Mig6, ERRFI1) is an inducible adaptor/scaffold protein whose expression can be induced by both stress and mitogenic signals. It contains multiple domains for protein-protein interaction and is involved in a broad spectrum of cellular functions. Gene 33 promotes apoptosis in a cell type-dependent manner. A recent study has linked Gene 33 to the DNA damage response (DDR) induced by hexavalent chromium [Cr(VI)]. Here we show that Gene 33 induces apoptosis via both c-Abl/p73 and EGFR/AKT-dependent pathways in lung epithelial and lung carcinoma cells. Ectopic expression of Gene 33 also triggers DDR in an ATM-dependent fashion and through pathways with or without association with apoptosis. We observed significant presence of Gene 33 in the nucleus and chromatin. We show that the nuclear localization of Gene 33 is dependent on its 14-3-3 binding domain. We find that the chromatin localization of Gene 33 is, at least in part, dependent on its EBD motif. Our data also show that Gene 33 may regulate chromatin targeting of c-Abl and EGFR. Moreover, we observed strong association of Gene 33 with histone H2AX and that Gene 33 promotes interaction between ATM and histone H2AX without triggering DNA damage. Our study reveals novel nuclear functions of Gene 33, which mediate DDR and apoptosis through independent mechanisms. Given our previous finding that Gene 33 depletion promotes Cr(VI)-induced DNA damage, our data suggest that Gene 33 may foster DNA repair by activating DDR

Local transformation of mixed states of two qubits to Bell diagonal states

The optimal entanglement manipulation for a single copy of mixed states of two qubits is to transform it to a Bell diagonal state. In this paper we derive an explicit form of the local operation that can realize such a transformation. The result obtained is universal for arbitrary entangled two-qubit states and it discloses that the corresponding local filter is not unique for density matrices with rank $n=2$ and can be exclusively determined for that with $n=3$ and 4. As illustrations, a four-parameters family of mixed states are explored, the local filter as well as the transformation probability are given explicitly, which verify the validity of the general result.Comment: 5 pages, to be published in Phys. Rev.

Fire behaviour of concrete filled elliptical steel columns

In this work, a non-linear three-dimensional finite element model is presented in order to study the behaviour of axially loaded concrete filled elliptical hollow section (CFEHS) columns exposed to fire. This study builds on previous work carried out by the authors on concrete filled circular hollow section (CFCHS) columns both at room temperature and in fire. The numerical model is first validated at room temperature against a series of experiments on CFEHS stub columns available in the literature and subsequently extended to study the performance of slender columns at elevated temperatures. The aim of this work is to understand and represent the behaviour of axially loaded CFEHS columns in fire situations and to compare their effectiveness with that of the circular concrete filled tubular (CFT) columns. Parametric studies to explore the influence of variation in global member slenderness, load level, cross-section slenderness and section size are presented. Finally, guidance on the fire design of CFEHS columns is proposed: it is recommended to follow the guidelines of Clause 4.3.5.1 in EN 1994-1-2, but employing the flexural stiffness reduction coefficients established in the French National Annex with an equivalent EHS diameter equal to P/¿, where P is the perimeter of the ellipse.The authors would also like to acknowledge Universidad Politecnica de Valencia for providing fellowship funding for the first author's stay as a visiting academic at Imperial College London.Espinós Capilla, A.; Gardner, L.; Romero, ML.; Hospitaler Pérez, A. (2011). Fire behaviour of concrete filled elliptical steel columns. Thin-Walled Structures. 49(2):239-255. https://doi.org/10.1016/j.tws.2010.10.008S23925549

{μ-trans-N,N′-Bis[(diphenyl­phosphan­yl)meth­yl]benzene-1,4-diamine-κ2 P:P′}bis­{(acetonitrile-κN)[dipyrido[3,2-a:2′,3′-c]phenazine-κ2 N 4,N 5]copper(I)} bis­(tetra­fluoridoborate)

In the centrosymmetric dinuclear title compound, [Cu2(C2H3N)2(C18H10N4)2(C32H30N2P2)](BF4)2, the CuI centre is coordinated by two N atoms from a dipyridophenazine ligand, one P atom from an N,N′-bis­[(diphenyl­phosphan­yl)meth­yl]benzene-1,4-diamine (bpbda) ligand, and one N atom from an acetonitrile mol­ecule in a distorted tetra­hedral geometry. The bpbda ligand, lying on an inversion center, bridges two CuI centres into a Z-shaped complex. Intra­molecular π–π inter­actions between the dipyridophenazine ligand and the benzene ring of the bpbda ligand are observed [centroid–centroid distance = 3.459 (3) Å]. The crystal structure also involves inter­molecular π–π inter­actions between the dipyridophenazine ligands [centroid–centroid distance = 3.506 (3) Å], which lead to a one-dimensional supra­molecular structure