13 research outputs found
Myanmar Climate-Smart Agriculture Strategy
Myanmar has committed to apply CSA to contribute to regional food security and environmental protection during the 24th ASEAN Summit on May 10, 2014. The Myanmar CSA strategy encompasses the development of technical, policy and investment conditions to achieve a sustainable agricultural development for food security and nutrition through climate-resilient and sustainable agriculture. Myanmar’s CSA strategy aims to be socially, culturally and politically appropriate, environment-friendly and economically feasible to promote and attain sustainable agriculture, food security and nutrition, agricultural development and climate change adaptation and mitigation. Myanmar’s CSA strategy also aims to provide context and analysis for addressing agriculture in international climate negotiations to better inform climate negotiators and other stakeholders by identifying options and unpacking issues of interest
Partitioning genetic effects due to embryo, cytoplasm and maternal parent for oil content in oilseed rape (Brassica napus L.)
Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles
Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology, underlining the need for novel therapeutic approaches. Typically, patients with high risk disease undergo an initial remission in response to treatment, followed by disease recurrence that has become refractory to further treatment. Here, we demonstrate the first silica nanoparticle-based targeted delivery of a tumor suppressive, pro-apoptotic microRNA, miR-34a, to neuroblastoma tumors in a murine orthotopic xenograft model. These tumors express high levels of the cell surface antigen disialoganglioside GD2 (GD(2)), providing a target for tumor-specific delivery.Nanoparticles encapsulating miR-34a and conjugated to a GD(2) antibody facilitated tumor-specific delivery following systemic administration into tumor bearing mice, resulted in significantly decreased tumor growth, increased apoptosis and a reduction in vascularisation. We further demonstrate a novel, multi-step molecular mechanism by which miR-34a leads to increased levels of the tissue inhibitor metallopeptidase 2 precursor (TIMP2) protein, accounting for the highly reduced vascularisation noted in miR-34a-treated tumors.These novel findings highlight the potential of anti-GD(2)-nanoparticle-mediated targeted delivery of miR-34a for both the treatment of GD(2)-expressing tumors, and as a basic discovery tool for elucidating biological effects of novel miRNAs on tumor growth
Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression
A State of Knowledge of the Salween River: An Overview of Civil Society Research
This chapter presents an overview of civil society research on Salween, providing an overview of the existing knowledge of the basin and a start to identifying key knowledge gaps in support of more informed, inclusive, and accountable water governance in the basin
Mitigation potential of important farm and forest trees: a potentiality for clean development mechanism afforestation reforestation (CDM A R) project and reducing emissions from deforestation and degradation, along with conservation and enhancement of carbon stocks (REDD+)
Regulation of Endometrial Fibroblast Growth Factor 7 (FGF-7) and Its Receptor FGFR2IIIb in Gilts after Sex Steroid Replacements, and during the Estrous Cycle and Early Gestation
Cultural diversity in China: Dialect, job embeddedness, and turnover
Dialect, Cultural diversity, Job embeddedness, Turnover, China,