Staden som en kollektiv aktör En abduktiv fallstudie på Malmö stad

Abstract Cities are once again becoming the locus of economic, social and political processes. The effect of these processes on the city is two-fold: one one hand they threaten to fragment and dislocate the city and the actors within them, on the other hand they give actors within cities new opportunities to react and mobilize resources towards different strategies of integration. The latter gives rise to what Patrick Le Galès calls the collective actor-city. The aim of this thesis is to explore the notion of the city as a collective actor in a swedish context by utilizing Le Galès theory of european cities as collective actors in an abductive case study on the city of Malmoe. By utilizing Le Galès five dimensions that make up a collective actor I analyze interviews conducted with city officals aswell as documents produced from the city wide plan of action Welfare for everybody. My findings are that while there is a high risk of fragmentation and dislocation in the city several mechanisms for integration of different interests are at work. Thus it is possible to conclude that while Malmoe cannot be considered a collective actor in the fullest sense of the word, it is a collective actor in the making

Läkemedelsdistributionen i Norden. En komparativ studie av aktörer, resurser och aktiviteter.

This paper reports on a preliminary studie of the organising of pharmaceutical goods distribution in the Nordic countries. Based on close descriptions of the four national markets, Sweden, Denmark, Norway and Finland, a comparative analysis is made. The chosen comparative dimensions are: activity structures and actor constellations; vertical and horisontal integration; service levels; and pricing system. Despite their apparent similarities the four national markets display many differences in these dimensions. Further, within each national market, there are considerable differences between how the distribution operations are described in principle and how they appear when observed in practice.pharmaceuticals; goods distribution; market re-regulation; pricing

Surface strength of materials to the method of friction

Influenza A virus (IAV) has its natural reservoir in wild waterfowl, and emerging human IAVs often contain gene segments from avian viruses. The active drug metabolite of oseltamivir (oseltamivir carboxylate [OC]), stockpiled as Tamiflu for influenza pandemic preparedness, is not removed by conventional sewage treatment and has been detected in river water. There, it may exert evolutionary pressure on avian IAV in waterfowl, resulting in the development of resistant viral variants. A resistant avian IAV can circulate among wild birds only if resistance does not restrict viral fitness and if the resistant virus can persist without continuous drug pressure. In this in vivo mallard (Anas platyrhynchos) study, we tested whether an OC-resistant avian IAV (H1N1) strain with an H274Y mutation in the neuraminidase (NA-H274Y) could retain resistance while drug pressure was gradually removed. Successively infected mallards were exposed to decreasing levels of OC, and fecal samples were analyzed for the neuraminidase sequence and phenotypic resistance. No reversion to wild-type virus was observed during the experiment, which included 17 days of viral transmission among 10 ducks exposed to OC concentrations below resistance induction levels. We conclude that resistance in avian IAV that is induced by exposure of the natural host to OC can persist in the absence of the drug. Thus, there is a risk that human-pathogenic IAVs that evolve from IAVs circulating among wild birds may contain resistance mutations. An oseltamivir-resistant pandemic IAV would pose a substantial public health threat. Therefore, our observations underscore the need for prudent oseltamivir use, upgraded sewage treatment, and surveillance for resistant IAVs in wild birds

On the importance of AI research beyond disciplines

As the impact of AI on various scientific fields is increasing, it is crucial to embrace interdisciplinary knowledge to understand the impact of technology on society. The goal is to foster a research environment beyond disciplines that values diversity and creates, critiques and develops new conceptual and theoretical frameworks. Even though research beyond disciplines is essential for understanding complex societal issues and creating positive impact it is notoriously difficult to evaluate and is often not recognized by current academic career progression. The motivation for this paper is to engage in broad discussion across disciplines and identify guiding principles fir AI research beyond disciplines in a structured and inclusive way, revealing new perspectives and contributing to societal and human wellbeing and sustainability

Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up

Background: Serum selenium level (s-Se) has been associated with prostate cancer (PrCa) risk. We investigated the relation between s-Se, smoking and non-screening detected PrCa and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se. Methods: ULSAM, a population based Swedish male cohort (n = 2322) investigated at age 50 for s-Se and s-Se influencing factors: serum cholesterol, erythrocyte sedimentation rate and smoking habits. At age 71 a subcohort, (n = 1005) was genotyped for OGG1 and MnSOD polymorphisms. Results: In a 34-year-follow-up, national registries identified 208 PrCa cases further confirmed in medical records. Participants with s-Se in the upper tertile had a non-significantly lower risk of PrCa. Smokers with s-Se in the two lower tertiles (<= 80 mu g/L) experienced a higher cumulative incidence of PrCa than smokers in the high selenium tertile (Hazard Ratio 2.39; 95% CI: 1.09-5.25). A high tertile selenium level in combination with non-wt rs125701 of the OGG1 gene in combination with smoking status or rs4880 related variation of MnSOD gene appeared to protect from PrCa. Conclusions: S-Se levels and smoking habits influence long-term risk of PrCa. Smoking as a risk factor for PrCa in men with low s-Se is relevant to explore further. Exploratory analyses of variations in OGG1 and MnSOD genes indicate that hypotheses about patterns of exposure to selenium and smoking combined with data on genetic variation in genes involved in DNA repair can be valuable to pursue

Towards markerless analysis of human motion

The topic for this thesis is the analysis of human movement, or more specifically, markerless analysis of human movement from video material. By markerless analysis is meant that the full image material is used as input in contrast with traditional marker systems that only use the positions of marker centers. The basic idea is to use more of the information in the images to improve the analysis. Starting of with the aim of markerless analysis an application is designed that use, to the subject added texture to estimate the position of the knee joint center in real images. The approach show the plausibility of using subject texture for estimation purposes. Another issue that is addressed is how one can generate synthetic image data. Using basic tools of graphics programming a virtual environment used to synthesize data is created. This environment is also used to evaluate some different camera solutions. One method to make three dimensional reconstruction from multiple images of an object is tested using the synthetic data. The method is based on a "brute force" approach and does not show good performance in terms of computing speed. With appropriate representations of the three dimensional objects, mathematical methods might speed up the analysis