Conviviality under the cosmopolitan canopy? Social mixing and friendships in an urban secondary school

This article is available open access through the publisher’s website at the link below. Copyright © Sociological Research Online 2012.Social mix and social mixing are topics of increasing significance to both the policy and academic communities in the UK, and have particular salience in urban multi-ethnic and socially diverse contexts. Enshrined in the comprehensive school ideal, and implicated in the now legal duty to promote 'community cohesion,' (urban) schools play a pivotal role in agendas for social mixing but little is empirically known about how this is lived and experienced by the young people in those schools. This paper begins to develop a theoretical understanding of social mixing drawing on qualitative data on the patterns, discourses, and experiences of associations and friendships collected in a London comprehensive school. We find that while the social mix of the school is celebrated, in official discourse as congenial and 'convivial', by staff and students alike, the extent of actual mixing - of associations and friendships forming between those of different social and ethnic backgrounds - is both constrained and complex. We point to the social and cultural factors which produce this sense of conviviality, and the opportunities for cultural learning it supports. At the same time, we argue that there are limitations. Schools are sites of differentiation, and friendships as exemplars of social mixing, both (re)produce and are (re)produced by existing social hierarchies and inequalities

Is Targeting Formal Childcare the Best Way to Meet the Needs of Families in Britain?

The overall aim of this paper is to examine the types and combinations of childcare being used by parents in Britain, and to compare how this childcare usage may vary between families, in order to critically examine parental childcare needs. The three specific research questions were: 1) ‘What types and combinations of childcare are being used by families?’, 2) ‘What are the socio-demographic comparisons between families using and not using childcare?’ And 3) ‘How do types of childcare vary between families?. These questions were addressed by carrying out a secondary analysis of large-scale nationally representative datasets which provide information about patterns of childcare usage in the UK. Two main datasets were used: the Family Resources Survey and the Childcare and Early Years Survey of Parents, with analysis carried out for the years 2008 to 2013. The analysis carried out comes from a wider study seeking to examine the provision and use of preschool childcare in Britain. The findings show that despite policies to increase the use of formal childcare, parents continue to be reliant on informal care, especially grandparents, to supplement their childcare needs. Furthermore, childcare use is not equally distributed, but is related to family circumstances. For example formal care is used more by employed, higher income families, whilst informal care is used more by mothers who are not employed, less well educated and by younger mothers. The results overall suggest that formal and informal childcare in combination will better support maternal employment. Future government policy needs to address supporting this mixed provision. The data however says nothing about parental childcare preferences which are needed to unpack the observed patterns of childcare usage in the UK

Is the ‘quality’ of preschool childcare, measured by the qualifications and pay of the childcare workforce, improving in Britain?

The purpose of this paper is to report on the changing qualifications, pay and working conditions of the British childcare workforce between 2005 and 2014. This is in order to contribute to current debates on the ‘quality’ of childcare provision for preschool children. The theoretical framework for this study draws upon concepts of 'quality' in childcare, to discuss the argued importance of increasing access to and raising standards of childcare for children’s cognitive development, for women’s labour market participation and for reducing poverty. The analysis comes from an ESRC funded study entitled ‘Provision and use of preschool childcare in Britain’. This paper focuses on examination of childcare provision by the formal childcare workforce and presents results from a secondary analysis of the UK’s Labour Force Survey, Childcare and Early Years Providers Survey, Annual Survey of Hours and Earnings, and Ofsted registration data. The 2005-2014 results show a highly gendered (98% female), low valued workforce in which qualifications are modestly rising (12% increase over time in NVQ level 3) but persistently low paid (on average £6.60 per hour) compared with other occupations (£13.10 per hour). The study also finds a shrinkage in the childcare workforce - of around five per cent in Britain since 2005 (from 329k in 2005-07 to 313k in 2012-14) – and more people describing themselves as childminders in the LFS than are registered with Ofsted, suggesting a possible growth in illegal childminding. The implications of these findings raise questions about what the British childcare workforce will look like in the future, who will do childcare work in the future, and whether it is possible to achieve ‘good quality’, ‘affordable childcare’ and ‘decent pay’ for British childcare workers. These issues are important for the future regulation of the British ‘childcare’ workforce and policy development in this vital area

Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.

Social vigilance is a behavioral strategy commonly used in adverse or changing social environments. In animals, a combination of avoidance and vigilance allows an individual to evade potentially dangerous confrontations while monitoring the social environment to identify favorable changes. However, prolonged use of this behavioral strategy in humans is associated with increased risk of anxiety disorders, a major burden for human health. Elucidating the mechanisms of social vigilance in animals could provide important clues for new treatment strategies for social anxiety. Importantly, during adolescence the prevalence of social anxiety increases significantly. We hypothesize that many of the actions typically characterized as anxiety behaviors begin to emerge during this time as strategies for navigating more complex social structures. Here, we consider how the social environment and the pubertal transition shape neural circuits that modulate social vigilance, focusing on the bed nucleus of the stria terminalis and prefrontal cortex. The emergence of gonadal hormone secretion during adolescence has important effects on the function and structure of these circuits, and may play a role in the emergence of a notable sex difference in anxiety rates across adolescence. However, the significance of these changes in the context of anxiety is still uncertain, as not enough studies are sufficiently powered to evaluate sex as a biological variable. We conclude that greater integration between human and animal models will aid the development of more effective strategies for treating social anxiety

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1). In the cell, phosphorylation promotes the interaction of KSRP and 14-3-3ζ protein and impairs the ability of KSRP to promote the degradation of its RNA targets. Here we examine the molecular details of this mechanism. We report that phosphorylation leads to the unfolding of the structurally atypical and unstable KH1, creating a site for 14-3-3ζ binding. Using this site, 14-3-3ζ discriminates between phosphorylated and unphosphorylated KH1, driving the nuclear localization of KSRP. 14-3-3ζ –KH1 interaction regulates the mRNA-decay activity of KSRP by sequestering the protein in a separate functional pool. This study demonstrates how an mRNA-degradation pathway is connected to extracellular signaling networks through the reversible unfolding of a protein domain.European Molecular Biology Organization 240-2005Italian CIPE-200

A tamoxifen receptor within a voltage-gated sodium channel

Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well characterized. We describe the identification of a previously unidentified receptor site within the NavMs voltage-gated sodium channel. Tamoxifen, an estrogen receptor modulator, and its primary and secondary metabolic products bind at the intracellular exit of the channel, which is a site that is distinct from other previously characterized sodium channel drug sites. These compounds inhibit NavMs and human sodium channels with similar potencies and prevent sodium conductance by delaying channel recovery from the inactivated state. This study therefore not only describes the structure and pharmacology of a site that could be leveraged for the development of new drugs for the treatment of sodium channelopathies but may also have important implications for off-target health effects of this widely used therapeutic drug