23 research outputs found

    Climate change impacts on ocean circulation relevant to the UK and Ireland

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    What is happening ‱ Observations of the Atlantic Meridional Overturning Circulation or Gulf Stream System since the 1980s have shown a strengthening in the 1990s and a weakening in the 2000s, with no clear overall trend. ‱ Shifts in North-east Atlantic circulation, leading to a greater influence of warmer subtropical-origin waters which can impact marine ecosystems and economically important fish species such as mackerel. The changing subpolar ocean circulation is also having impacts on the food supply for deep-sea ecosystems. ‱ The subpolar gyre recorded its freshest values on record in the 2010s. Ongoing freshwater build-up in the rapidly changing Arctic Ocean may exacerbate this freshening. What could happen ‱ Projections from climate models consistently project a weakening of the Atlantic Meridional Overturning Circulation due to anthropogenic climate change. ‱ Warming of Atlantic waters is expected to reduce the depth of mixed layers and limit nutrient supply to surface layers

    Context Modelling and Management in Ambient-aware Pervasive Environments

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    Services in pervasive computing systems must evolve so that they become minimally intrusive and exhibit inherent proactiveness and dynamic adaptability to the current conditions, user preferences and environment. Context awareness has the potential to greatly reduce the human attention and interaction bottlenecks, to give the user the impression that services fade into the background, and to support intelligent personalization and adaptability features. To establish this functionality, an infrastructure is required to collect, manage, maintain, synchronize, infer and disseminate context information towards applications and users. This paper presents a context model and ambient context management system that have been integrated into a pervasive service platform. This research is being carried out in the DAIDALOS IST Integrated Project for pervasive environments. The final goal is to integrate the platform developed with a heterogeneous all-IP network, in order to provide intelligent pervasive services to mobile and non-mobile users based on a robust context-aware environment

    Export activities and prospects of hawaiian firms

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    Over the past ten years exports from the Pacific region have increased dramatically. Within this region, Hawaii is of particular interest for US trade development purposes. Investigating export activities and prospects of Hawaiian firms is useful to obtaining a better understanding of international trade. This article reports the results of such an investigation

    Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants

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    Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci for both disorders, looking for potential overlap of signals. We then analyzed the overall shared genetic load using polygenic scores and estimated the genetic correlation between disease subtypes using data derived from these models. We further interrogated genomic regions of shared risk using analysis of covariance patterns between the 2 phenotypes using cross-phenotype spatial mapping. Results: We found substantial genetic overlap between migraine and IS using all 4 approaches. Migraine without aura (MO) showed much stronger overlap with IS and its subtypes than migraine with aura (MA). The strongest overlap existed between MO and large artery stroke (LAS; p 6.4 × 10-28 for the LAS polygenic score in MO) and between MO and cardioembolic stroke (CE; p 2.7 × 10-20 for the CE score in MO). Conclusions: Our findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype
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