Undamped nonequilibrium dynamics of a nondegenerate Bose gas in a 3D isotropic trap

We investigate anomalous damping of the monopole mode of a non-degenerate 3D Bose gas under isotropic harmonic confinement as recently reported by the JILA TOP trap experiment [D. S. Lob- ser, A. E. S. Barentine, E. A. Cornell, and H. J. Lewandowski (in preparation)]. Given a realistic confining potential, we develop a model for studying collective modes that includes the effects of anharmonic corrections to a harmonic potential. By studying the influence of these trap anharmonicities throughout a range of temperatures and collisional regimes, we find that the damping is caused by the joint mechanisms of dephasing and collisional relaxation. Furthermore, the model is complimented by Monte Carlo simulations which are in fair agreement with data from the JILA experiment.Comment: 11 pages, 6 figure

Gate recess engineering of pseudomorphic In0.30GaAs/GaAs HEMTs

The authors report how the performance of 0.12 μm GaAs pHEMTs is improved by controlling both the gate recess width, using selective dry etching, and the gate position in the source drain gap, using electron beam lithography. pHEMTs with a transconductance of 600 mS/mm, off state breakdown voltages >2 V, fτ of 120 GHz, f max of 180 GHz and MAG of 13.5 dB at 60 GHz are reported

Georgia Tech Industrial Development Manual

Issued as Project no. E-127-

Improving Access to Trails and Green Space: Brightwood Neighborhood, Springfield, Massachusetts

Accessibility has been an issue with the Connecticut River Walk and Bikeway (River Walk) since its completion in 2003. Our project focuses on designing better connections between this Springfield, MA rail trail and the local environmental justice communities it is meant to serve. As a team of four undergraduate design students, we have spent three months conducting a comprehensive research study on the trail. Ultimately, we will be turning over our research to the Appalachian Mountain Club which intends to use it for reference in their efforts to secure funding for improving River Walk access in the city of Springfield. As part of an undergraduate design studio class under the instruction of Professor Michael DiPasquale, our team conducted extensive research on the Connecticut River Walk and Bikeway. Looking through the lens of equity, we identified a cogent lack of access to this rail trail from the Brightwood neighborhood, to which it runs parallel. Similar environmental justice issues in Springfield have been studied by UMass students in the past, such as “Making Connections — Envisioning Springfield’s North End,” and Healthy Place-Making: Revitalizing Springfield’s Medical District, completed in graduate urban design studios in 2009 and 2019, respectively. Our work this semester builds upon these previous studies, while also delineating itself through our focus on the River Walk specifically. Our study consists of four parts: research, community engagement, design solutions, and deliverables. Much like a traditional planning project, these objectives were completed in a partially chronological fashion. Our approach consisted of overlaps between each component — as much as our research informed our engagement, what we learned from our engagement also informed our research, and so on. With the ultimate goal of providing the Appalachian Mountain Club with a wealth of information supporting the need for funding for improvements to the Connecticut River Walk and Bikeway, our team combined the results of our research, engagement, and design into this document: our deliverable for the project

Loss of ATM/Chk2/p53 Pathway Components Accelerates Tumor Development and Contributes to Radiation Resistance in Gliomas

SummaryMaintenance of genomic integrity is essential for adult tissue homeostasis and defects in the DNA-damage response (DDR) machinery are linked to numerous pathologies including cancer. Here, we present evidence that the DDR exerts tumor suppressor activity in gliomas. We show that genes encoding components of the DDR pathway are frequently altered in human gliomas and that loss of elements of the ATM/Chk2/p53 cascade accelerates tumor formation in a glioma mouse model. We demonstrate that Chk2 is required for glioma response to ionizing radiation in vivo and is necessary for DNA-damage checkpoints in the neuronal stem cell compartment. Finally, we observed that the DDR is constitutively activated in a subset of human GBMs, and such activation correlates with regions of hypoxia

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

SummaryeNOS expression is elevated in human glioblastomas and correlated with increased tumor growth and aggressive character. We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas. eNOS expression is highly elevated in tumor vascular endothelium adjacent to perivascular glioma cells expressing Nestin, Notch, and the NO receptor, sGC. In addition, the NO/cGMP/PKG pathway drives Notch signaling in PDGF-induced gliomas in vitro, and induces the side population phenotype in primary glioma cell cultures. NO also increases neurosphere forming capacity of PDGF-driven glioma primary cultures, and enhances their tumorigenic capacity in vivo. Loss of NO activity in these tumors suppresses Notch signaling in vivo and prolongs survival of mice. This mechanism is conserved in human PDGFR amplified gliomas. The NO/cGMP/PKG pathway's promotion of stem cell-like character in the tumor PVN may identify therapeutic targets for this subset of gliomas

Causality

Making correct causal claims is important for research and practice. This article explains what causality is, and how it can be established via experimental design. Because experiments are infeasible in many applied settings, researchers often use "observational" methods to estimate causal models. In these situations, it is likely that model estimates are compromised by endogeneity. The article discusses the conditions that engender endogeneity and methods that can eliminate it

Nuclear Disks of Gas and Dust in Early Type Galaxies and the Hunt for Massive Black Holes: Hubble Space Telescope Observations of NGC 6251

We discuss Hubble Space Telescope optical images and spectra of NGC 6251, a giant E2 galaxy and powerful radio source at a distance of 106 Mpc (for H_0 = 70 km/s/Mpc). The galaxy is known to host a very well defined dust disk (O'Neil et al. 1994); the exceptional resolution of our V and I images allows a detailed study of the disk structure. Furthermore, narrow band images centered on the Halpha+[NII] emission lines, reveal the presence of ionized gas in the inner 0.3 arcsec of the disk. We used the HST/Faint Object Spectrograph with the 0.09 arcsec aperture to study the velocity structure of the disk. Dynamical models were constructed for two extreme (in terms of central concentration) analytical representations of the stellar surface brightness profile, from which the mass density and corresponding rotational velocity are derived assuming a constant mass-to-light ratio (M/L)_V ~ 8.5 M_solar/L_solar. For both representations of the stellar component, the models show that the gas is in Keplerian motion around a central mass ~ 4 - 8 X 10^8 solar masses, and that the contribution of radial flows to the velocity field is negligible.Comment: 45 pages, submitted to Ap