Fluids and barriers of the CNS: a historical viewpoint

Tracing the exact origins of modern science can be a difficult but rewarding pursuit. It is possible for the astute reader to follow the background of any subject through the many important surviving texts from the classical and ancient world. While empirical investigations have been described by many since the time of Aristotle and scientific methods have been employed since the Middle Ages, the beginnings of modern science are generally accepted to have originated during the 'scientific revolution' of the 16th and 17th centuries in Europe. The scientific method is so fundamental to modern science that some philosophers consider earlier investigations as 'pre-science'. Notwithstanding this, the insight that can be gained from the study of the beginnings of a subject can prove important in the understanding of work more recently completed. As this journal undergoes an expansion in focus and nomenclature from cerebrospinal fluid (CSF) into all barriers of the central nervous system (CNS), this review traces the history of both the blood-CSF and blood-brain barriers from as early as it was possible to find references, to the time when modern concepts were established at the beginning of the 20th century

Facilitating digital work in public agencies through job design and digital communication management: Validating empirically and theoretically derived implications on digital leadership using expert interviews

Digitalization affects public servants’ job demands and resources. The current paper investigates which measures managers can employ to optimize digital work on administrative procedures. Building on a previous study on the impact of digitalization on work experiences and performance in public agencies and on a literature research regarding leadership instruments, we derived two sets of measures on job design and digital communication management. The proposed measures were validated conducting expert interviews with actual and prospective managers from various municipal agencies. Overall, our analyses revealed heterogenous patterns regarding the prevalence of the proposed measures. Experts reported various potential benefits and challenges as well as suitable recommendations regarding their implementations which indicates that the proposed measures could indeed contribute to facilitating digital work on administrative procedures. Finally, the practical implications as well as limitations of our approach are discussed

Intractable partial epilepsy following low dose scalp irradiation in infancy

We report the development of intractable epilepsy in 3 patients treated with irradiation to strawberry scalp nevi in infancy. Low-dose radiation was used (12 and 13 Gy in 2 of the patients). The clinical evolution suggested a recognizable and distinctive postradiation syndrome. There was concordance between the site of radiation as shown by localized alopecia, the clinical features of the partial seizures, and electrographic abnormalities. The clinical picture was unlike delayed cerebral radiation necrosis of adulthood, which is not thought to occur at doses below 50 Gy, in 2-Gy fractions. Neurological deficits were not progressive and in 2 patients there was no evidence of parenchymal injury on cranial magnetic resonance imaging scanning. These differences suggest pathogenetic differences to cerebral radiation injury of adulthood, probably relating to the interaction between nervous system development, individual susceptibility, and the low doses of radiation employed