Controls on the spatial distribution of oceanic <i>δ</i>¹³C_DIC

We describe the design and evaluation of a large ensemble of coupled climate–carbon cycle simulations with the Earth system model of intermediate complexity GENIE. This ensemble has been designed for application to a range of carbon cycle questions, including the causes of late- Quaternary fluctuations in atmospheric CO2. Here we evaluate the ensemble by applying it to a transient experiment over the recent industrial era (1858 to 2008 AD). We employ singular vector decomposition and principal component emulation to investigate the spatial modes of ensemble variability of oceanic dissolved inorganic carbon (DIC) δ13C, considering both the spun-up pre-industrial state and the transient change. These analyses allow us to separate the natural (preindustrial) and anthropogenic controls on the δ13CDIC distribution. We apply the same dimensionally reduced emulation techniques to consider the drivers of the spatial uncertainty in anthropogenic DIC. We show that the sources of uncertainty related to the uptake of anthropogenic δ13CDIC and DIC are quite distinct. Uncertainty in anthropogenic δ13C uptake is controlled by air–sea gas exchange, which explains 63% of modelled variance. This mode of variability is largely absent from the ensemble variability in CO2 uptake, which is rather driven by uncertainties in thermocline ventilation rates. Although the need to account for air–sea gas exchange is well known, these results suggest that, to leading order, uncertainties in the ocean uptake of anthropogenic 13C and CO2 are governed by very different processes. This illustrates the difficulties in reconstructing one from the other, and furthermore highlights the need for careful targeting of both δ13CDIC and DIC observations to better constrain the ocean sink of anthropogenic CO2

Spectroscopic Confirmation of a Radio-Selected Galaxy Overdensity at z=1.11

We report the discovery of a galaxy overdensity at z=1.11 associated with the z=1.110 high-redshift radio galaxy MG0442+0202. The group, CL0442+0202, was found in a near-infrared survey of z>1 radio galaxies undertaken to identify spatially-coincident regions with a high density of objects red in I-K' color, typical of z>1 elliptical galaxies. Spectroscopic observations from the Keck telescope reveal five galaxies within 35" of MG0442+0202 at 1.10<z<1.11. These member galaxies have broad-band colors and optical spectra consistent with passively-evolving elliptical galaxies formed at high redshift. A 45ks Chandra X-Ray Observatory observation detects the radio galaxy and four point sources within 15" of the radio galaxy, corresponding to a surface density two orders of magnitude higher than average for X-ray sources at these flux levels, S(0.5-2keV) > 5e-16 erg/cm2/s. One of these point sources is identified with a radio-quiet, typeII quasar at z=1.863, akin to sources recently reported in deep Chandra surveys. The limit on an extended hot intracluster medium in the Chandra data is S(1-6keV) < 1.9e-15 erg/cm2/s (3-sigma, 30" radius aperture). Though the X-ray observations do not confirm the existence of a massive, bound cluster at z>1, the success of the optical/near-infrared targeting of early-type systems near the radio galaxy validates searches using radio galaxies as beacons for high-redshift large-scale structure. We interpret CL0442+0202 to be a massive cluster in the process of formation.Comment: 23 pages, 7 figure

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β. In addition, mouse caspase-11 (represented in humans by its orthologs, caspase-4 and caspase-5) detects cytosolic bacterial LPS directly. Activation of caspase-1 and caspase-11 initiates pyroptotic host cell death that releases potentially harmful bacteria from the nutrient-rich host cell cytosol into the extracellular environment. Here we use single cell analysis and time-lapse microscopy to identify a subpopulation of host cells, in which growth of cytosolic Salmonella Typhimurium is inhibited independently or prior to the onset of cell death. The enzymatic activities of caspase-1 and caspase-11 are required for growth inhibition in different cell types. Our results reveal that these proteases have important functions beyond the direct induction of pyroptosis and proinflammatory cytokine secretion in the control of growth and elimination of cytosolic bacteria

Qualitative Examination of African American Women's Perspectives about Depression

Gaining greater understanding about the various psychosocial, socio-cultural, and environmental factors that may influence experiences of depression among African American women (AAW) helps elucidate how this mental illness impacts the lives of this population. Sixty-three adult AAW comprised the study’s convenience sample.  Specifically, focus group cohorts inclusive of women from an academic institution, a primary healthcare clinic, and an urban community setting were conducted.  Results indicated six (6) dominant common themes as issues that may increase risk for depression among diverse AAW.  Similarities and differences about perspectives that contributed to depression were delineated among the three cohorts of AAW.  These results are important for mental/behavioral health researchers, practitioners, and public health professionals that are engaged in the design and implementation of culturally centered and gender-specific prevention and intervention strategies targeted to AAW at risk for depression. 

Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus

Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK. The epidemic lineage (Lineage C) had lost two typical emm3 prophages, Φ315.1 and Φ315.2 associated with the superantigen ssa, but gained a different prophage (ΦUK-M3.1) associated with a different superantigen, speC and a DNAse spd1. Methods and Results: The presence of speC and spd1 in Lineage C ST15 strains enhanced both in vitro mitogenic and DNAse activities over non-Lineage C ST15 strains. Invasive disease models in Galleria mellonella and SPEC-sensitive transgenic mice, revealed no difference in overall invasiveness of Lineage C ST15 strains compared to non-Lineage C ST15 strains, consistent with clinical and epidemiological analysis. Lineage C strains did however markedly prolong murine nasal infection with enhanced nasal and airborne shedding compared to non-Lineage C strains. Deletion of speC or spd1 in two Lineage C strains identified a possible role for spd1 in airborne shedding from the murine nasopharynx. Conclusions: Nasopharyngeal infection and shedding of Lineage C strains was enhanced compared to nonLineage C strains and this was, in part, mediated by the gain of the DNase spd1 through prophage acquisition

An X-ray Selected Galaxy Cluster at z=1.11 in the Rosat Deep Cluster Survey

We report the discovery of an X-ray luminous galaxy cluster at z =1.11. RDCS J0910+5422 was selected as an X-ray cluster candidate in the ROSAT Deep Cluster Survey on the basis of its spatial extent in a Rosat PSPC image. Deep optical and near-IR imaging reveal a red galaxy overdensity around the peak of the X-ray emission, with a significant excess of objects with J-K and I-K colors typical of elliptical galaxies at z ~ 1.0. Spectroscopic observations at the Keck II telescope secured 9 galaxy redshifts in the range 1.095<z<1.120 yielding a mean cluster redshift of =1.106. Eight of these galaxies lie within a 30 arcsec radius around the peak X-ray emission. A deep Chandra ACIS exposure on this field shows extended X-ray morphology and allows the X-ray spectrum of the intracluster medium to be measured. The cluster has a bolometric luminosity L_x = 2.48^{+0.33}_{-0.26} x 10^44 ergs/s, a temperature of kT = 7.2^{+2.2}_{-1.4} keV, and a mass within r = 1 Mpc of 7.0 x 10^14 M_sun (H_0=65 km/s/Mpc, Omega_m = 0.3, and Lambda = 0.7). The spatial distribution of the cluster members is elongated, which is not due to an observational selection effect, and followed by the X-ray morphology. The X-ray surface brightness profile and the spectrophotometric properties of the cluster members suggest that this is an example of a massive cluster in an advanced stage of formation with a hot ICM and an old galaxy population already in place at z > 1.Comment: 19 pages, 7 figures: Figures 1,4,6 included as separate jpg files. Accepted for publication in The Astronomical Journa

Building professional discourse in emerging markets: Language, context and the challenge of sensemaking

Using ethnographic evidence from the former Soviet republics, this article examines a relatively new and mainly unobserved in the International Business (IB) literature phenomenon of communication disengagement that manifests itself in many emerging markets. We link it to the deficiencies of the local professional business discourse rooted in language limitations reflecting lack of experience with the market economy. This hampers cognitive coherence between foreign and local business entities, adding to the liability of foreignness as certain instances of professional experience fail to find adequate linguistic expression, and complicates cross-cultural adjustments causing multi-national companies (MNCs) financial losses. We contribute to the IB literature by examining cross-border semantic sensemaking through a retrospectively constructed observational study. We argue that a relative inadequacy of the national professional idiom is likely to remain a feature of business environment in post-communist economies for some time and therefore should be factored into business strategies of MNCs. Consequently, we recommend including discursive hazards in the risk evaluation of international projects