Collisionless galaxy simulations

Three-dimensional fully self-consistent computer models were used to determine the evolution of galaxies consisting of 100 000 simulation stars. Comparison of two-dimensional simulations with three-dimensional simulations showed only a very slight stabilizing effect due to the additional degree of freedom. The addition of a fully self-consistent, nonrotating, exponential core/halo component resulted in considerable stabilization. A second series of computer experiments was performed to determine the collapse and relaxation of initially spherical, uniform density and uniform velocity dispersion stellar systems. The evolution of the system was followed for various amounts of angular momentum in solid body rotation. For initally low values of the angular momentum satisfying the Ostriker-Peebles stability criterion, the systems quickly relax to an axisymmetric shape and resemble elliptical galaxies in appearance. For larger values of the initial angular momentum bars develop and the systems undergo a much more drastic evolution

Electron dynamics in a plasma focus

Results are presented of a numerical integration of the three-dimensional relativistic equations of motion of electrons subject to given electric and magnetic fields deduced from experiments. Fields due to two different models are investigated. For the first model, the fields are those due to a circular distribution of axial current filaments. As the current filaments collapse toward the axis, large azimuthal magnetic and axial electric fields are induced. These fields effectively heat the electrons to a temperature of approximately 8 keV and accelerate electrons within the radius of the filaments to high axial velocities. Similar results are obtained for the current-reduction phase of focus formation. For the second model, the fields are those due to a uniform current distribution. Both the current-reduction and the compression phases were studied. These is little heating or acceleration of electrons during the compression phase because the electrons are tied to the magnetic field. However, during the current-reduction phase, electrons near the axis are accelerated toward the center electrode and reach energies of 100 keV. A criterion is obtained which limits the runaway electron current to about 400 A

a new Pc-C boundary section

The widespread, terminal Ediacaran Dengying Formation (~ 551–~ 542 Ma) of South China hosts one of the most prominent negative carbonate carbon isotope excursions in Earth's history and thus bears on the correlation of the Precambrian–Cambrian boundary worldwide. The dominantly carbonate strata of the Dengying Formation are largely studied for their unique preservation of its terminal Ediacaran fauna but their geochemical context is poorly known. This study presents the first high-resolution stable isotope record (δ13C, δ18O) of calcareous siliciclastic shallow-water deposits of the Gaojiashan section (Shaanxi Province). The section includes (in ascending order) the Algal Dolomite Member, the Gaojiashan Member and the Beiwan Member of the Dengying Formation. Our data record a major δ13Ccarb negative excursion to −6 ‰ in the uppermost Gaojiashan Member which is comparable in shape and magnitude to the global Precambrian–Cambrian boundary negative δ13C excursion. Our data set is consistent with a "shallow-water anoxia" scenario which is thought to contribute to the "Cambrian explosion". The stratigraphic occurrence of Cloudina and a large negative δ13C excursion suggest that the Precambrian–Cambrian boundary is located near the top of the Gaojiashan Member and, consequently, that overlying carbonates and dolomites of the Beiwan Member are of earliest Cambrian age. Thus the Gaojiashan section may represent a new shallow-water section spanning the Precambrian–Cambrian boundary. Although bio- and chemostratigraphic data support this novel interpretation, we cannot exclude the possibility that the key excursions may represent a local perturbation indicating a restricted-basin environment

Chaotic hysteresis in an adiabatically oscillating double well

We consider the motion of a damped particle in a potential oscillating slowly between a simple and a double well. The system displays hysteresis effects which can be of periodic or chaotic type. We explain this behaviour by computing an analytic expression of a Poincar'e map.Comment: 4 pages RevTeX, 3 PS figs, uses psfig.sty. Submitted to Phys. Rev. Letters. PS file also available at http://dpwww.epfl.ch/instituts/ipt/berglund.htm

Dynamics of modal power distribution in a multimode semiconductor laser with optical feedback

The dynamics of power distribution between longitudinal modes of a multimode semiconductor laser subjected to external optical feedback is experimentally analyzed in the low-frequency fluctuation regime. Power dropouts in the total light intensity are invariably accompanied by sudden activations of several longitudinal modes. These activations are seen not to be simultaneous to the dropouts, but to occur after them. The phenomenon is statistically analysed in a systematic way, and the corresponding delay is estimated.Comment: 3 pages, 4 figures, revte

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5

Legionella pneumophila can cause Legionnaires’ disease and replicates intracellularly in a distinct Legionella-containing vacuole (LCV). LCV formation is a complex process that involves a plethora of type IV-secreted effector proteins. The effector RidL binds the Vps29 retromer subunit, blocks retrograde vesicle trafficking, and promotes intracellular bacterial replication. Here, we reveal that the 29-kDa N-terminal domain of RidL (RidL2–281) adopts a “foot-like” fold comprising a protruding β-hairpin at its “heel”. The deletion of the β-hairpin, the exchange to Glu of Ile170 in the β-hairpin, or Leu152 in Vps29 abolishes the interaction in eukaryotic cells and in vitro. RidL2–281 or RidL displace the Rab7 GTPase-activating protein (GAP) TBC1D5 from the retromer and LCVs, respectively, and TBC1D5 promotes the intracellular growth of L. pneumophila. Thus, the hydrophobic β-hairpin of RidL is critical for binding of the L. pneumophila effector to the Vps29 retromer subunit and displacement of the regulator TBC1D5

Quasi-equilibria in one-dimensional self-gravitating many body systems

The microscopic dynamics of one-dimensional self-gravitating many-body systems is studied. We examine two courses of the evolution which has the isothermal and stationary water-bag distribution as initial conditions. We investigate the evolution of the systems toward thermal equilibrium. It is found that when the number of degrees of freedom of the system is increased, the water-bag distribution becomes a quasi-equilibrium, and also the stochasticity of the system reduces. This results suggest that the phase space of the system is effectively not ergodic and the system with large degreees of freedom approaches to the near-integrable one.Comment: 21pages + 7 figures (available upon request), revtex, submitted to Physical Review

Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease

MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in the regulation of gene expression and thereby in many physiological and pathological processes. Furthermore, miRNAs are released in the extracellular space, for example in vesicles, and are detectable in various biological fluids, such as serum, plasma, and urine. Over the last years, it has been shown that miRNAs are crucial in the development of several cardiovascular diseases (CVDs). This review discusses the (patho)physiological implications of miRNAs in CVD, ranging from cardiovascular risk factors (i.e., hypertension, diabetes, dyslipidemia), to atherosclerosis, myocardial infarction, and cardiac remodeling. Moreover, the intriguing possibility of their use as disease-specific diagnostic and prognostic biomarkers for human CVDs will be discussed in detail. Finally, as several approaches have been developed to alter miRNA expression and function (i.e., mimics, antagomirs, and target-site blockers), we will highlight the miRNAs with the most promising therapeutic potential that may represent suitable candidates for therapeutic intervention in future translational studies and ultimately in clinical trials. All in all, this review gives a comprehensive overview of the most relevant miRNAs in CVD and discusses their potential use as biomarkers and even therapeutic targets

Secular Evolution of Galaxy Morphologies

Today we have numerous evidences that spirals evolve dynamically through various secular or episodic processes, such as bar formation and destruction, bulge growth and mergers, sometimes over much shorter periods than the standard galaxy age of 10-15 Gyr. This, coupled to the known properties of the Hubble sequence, leads to a unique sense of evolution: from Sm to Sa. Linking this to the known mass components provides new indications on the nature of dark matter in galaxies. The existence of large amounts of yet undetected dark gas appears as the most natural option. Bounds on the amount of dark stars can be given since their formation is mostly irreversible and requires obviously a same amount of gas.Comment: 8 pages, Latex2e, crckapb.sty macros, 1 Postscript figure, replaced with TeX source; To be published in the proceeedings of the "Dust-Morphology" conference, Johannesburg, 22-26 January, 1996, D. Block (ed.), (Kluwer Dordrecht