Palaeomagnetic secular variation curves extending back to 13,400 years B.P. recorded by sediments deposited in Lac de Joux, Switzerland

Palaeosecular variation records have been obtained from three cores from Lac de Joux, Switzerland ( 46°37' N, 6°16' E) on which a parallel biostratigraphy has been constructed. All three cores show a well developed Late-glacial sequence which extends to beyond 13,400 years B.P. and the recorded palaeomagnetic declination and inclination variations can be correlated between these cores. The longer core (no. 3) also shows a well developed Post-glacial sequence and the declination and inclination records can be correlated in detail with the independently dated United Kingdom records which extend back to about 10,000 years B.P. Ages along Lac de Joux core 3, obtained by palaeomagnetic correlation with U.K. cores, are compared with ages based on the local palynology and thus a timescale has been attached to the Lac de Joux record back to beyond 13,400 years B.P. during which time there is no evidence of any geomagnetic excursion or short event.           ARK: https://n2t.net/ark:/88439/y079999 Permalink: https://geophysicsjournal.com/article/247 &nbsp

Basic concepts in quantum computation

Section headings: 1 Qubits, gates and networks 2 Quantum arithmetic and function evaluations 3 Algorithms and their complexity 4 From interferometers to computers 5 The first quantum algorithms 6 Quantum search 7 Optimal phase estimation 8 Periodicity and quantum factoring 9 Cryptography 10 Conditional quantum dynamics 11 Decoherence and recoherence 12 Concluding remarksComment: 37 pages, lectures given at les Houches Summer School on "Coherent Matter Waves", July-August 199

Grover search with pairs of trapped ions

The desired interference required for quantum computing may be modified by the wave function oscillations for the implementation of quantum algorithms[Phys.Rev.Lett.84(2000)1615]. To diminish such detrimental effect, we propose a scheme with trapped ion-pairs being qubits and apply the scheme to the Grover search. It can be found that our scheme can not only carry out a full Grover search, but also meet the requirement for the scalable hot-ion quantum computing. Moreover, the ion-pair qubits in our scheme are more robust against the decoherence and the dissipation caused by the environment than single-particle qubits proposed before.Comment: RevTe

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980�2015: a systematic analysis for the Global Burden of Disease Study 2015

Background Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. Methods We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14�294 geography�year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, life expectancy from birth increased from 61·7 years (95 uncertainty interval 61·4�61·9) in 1980 to 71·8 years (71·5�72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7�17·4), to 62·6 years (56·5�70·2). Total deaths increased by 4·1 (2·6�5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0 (15·8�18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1 (12·6�16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1 (11·9�14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1, 39·1�44·6), malaria (43·1, 34·7�51·8), neonatal preterm birth complications (29·8, 24·8�34·9), and maternal disorders (29·1, 19·3�37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146�000 deaths, 118�000�183�000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393�000 deaths, 228�000�532�000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost YLLs) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. Interpretation At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems. Funding Bill & Melinda Gates Foundation. © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY licens

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980�2015: a systematic analysis for the Global Burden of Disease Study 2015

Background Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. Methods We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14�294 geography�year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, life expectancy from birth increased from 61·7 years (95 uncertainty interval 61·4�61·9) in 1980 to 71·8 years (71·5�72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7�17·4), to 62·6 years (56·5�70·2). Total deaths increased by 4·1 (2·6�5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0 (15·8�18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1 (12·6�16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1 (11·9�14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1, 39·1�44·6), malaria (43·1, 34·7�51·8), neonatal preterm birth complications (29·8, 24·8�34·9), and maternal disorders (29·1, 19·3�37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146�000 deaths, 118�000�183�000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393�000 deaths, 228�000�532�000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost YLLs) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. Interpretation At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems. Funding Bill & Melinda Gates Foundation. © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY licens

An implicit algorithm for capturing sharp fluid interfaces in the volume of fluid advection method

The Volume of Fluid (VOF) method is one of the most effective methods employed in the simulation of two fluid flows with interfaces where density and viscosity change abruptly. These interfaces are represented implicitly by the values of a colour function which is a volume fraction of one of the fluids. The advantage of the method is its ability to deal with arbitrarily shaped interfaces and to cope with large deformations, as well as interface rupture and coalescence in a natural way. In comparison to a level set method, the mass is rigorously conserved in VOF, provided the discretisation is conservative, but one of the main difficulties is advecting the interface without diffusing, dispersing, or wrinkling it. This can either be performed algebraically, in schemes such as CICSAM or geometrically, in schemes such as PLIC. In the present paper, an algebraic advection scheme for the interface is presented, which is designed for the implicit time advancing algorithm. Analogous to CICSAM, the new scheme switches smoothly between ULTIMATE-QUICK and the upper bound of the universal limiter, depending on the angle between the interface and the flow direction. Four cases are tested with the present scheme: (i) solid body rotation; (ii) circle in a shear flow; (iii) dam-break and (iv) Rayleigh-Taylor instability. In the first two test cases, prescribed velocity fields are used, thereby allowing the effectiveness of the scheme in advecting the colour function only to be assessed. The scheme is found to outperform six other methods used for comparison in both studies. In solid body rotation simulations a fractional error of 0.19% is calculated in comparison to the next best recorded error of 1.1%. Similarly, in the longest shear flow simulation, a fractional error of 1.2% is calculated in comparison to the next best recorded error of 3.9%. In the final two test cases the advection equation for the colour function is coupled to the Navier-Stokes equations. In dam-break simulations it is found that the resulting solution effectively captures the trends displayed in experimental data for the advancing water front and the residual height of the liquid column against time. Qualitative results obtained for the Rayleigh-Taylor instability modelling in test case four are found to compare favourably to previous numerical simulations of the same phenomenon

The Dynamics of Dynamic Variable Ordering Heuristics

. It has long been accepted that dynamic variable ordering heuristics outperform static orderings. But just how dynamic are dynamic variable ordering heuristics? This paper examines the behaviour of a number of heuristics, and attempts to measure the entropy of the search process at different depths in the search tree. 1 Introduction Many studies have shown that dynamic variable ordering (dvo [9]) heuristics out perform static variable ordering heuristics. But just how dynamic are dynamic variable ordering heuristics? This might be important because if we discover that some dvo heuristic H 1 results in less search effort than heuristic H 2 and H 1 is more dynamic than H 2 then we might expect that we can make a further improvement by increasing the dynamism of H 1 . Conversely if we discover that H 1 is better and less dynamic then we might plan to make H 1 even more ponderous. But how do we measure the dynamism of a heuristic? To investigate this we first look inside the search proc..

In-Plane Optical Anisotropy of GaN Refractive Index in Visible Light Region

The optical properties of metal-organic chemical vapor deposition gallium nitride layers were measured with the use of a grating-assisted optical coupler. The application of a waveguide-based grating structure for in-coupling of radiated modes was the basis of the work presented here. A set of six grating couplers, providing different propagation angles with respect to the a-axis of GaN, was fabricated in a multimode GaN planar waveguide layer grown directly on c-axis (0001) sapphire. Measurements of the refractive index were carried out for laser wavelength lambda = 632.8 nm and both transverse-electric and transverse-magnetic polarized light. It was found that the refractive indices were dependent not only on the polarization state but also on the propagation direction of the excited optical mode in the plane. The 60 degree periodic in-plane anisotropy of GaN optical properties in the visible spectrum was clearly observed with maximum refractive index difference Delta n = 0.018 for both polarization